STRINGSTRING
PIK3CA PIK3CA SLA SLA CRADD CRADD NRAS NRAS LOC109502223 LOC109502223 ENSFCAP00000026617 ENSFCAP00000026617 GRB2 GRB2 FOXO3 FOXO3 SOS1 SOS1 FLT3LG FLT3LG CSDE1 CSDE1 RPS27A RPS27A CSK CSK AKT2 AKT2 ERAS ERAS HRAS HRAS SH2B3 SH2B3 AKT3 AKT3 FLT3 FLT3 PTPRJ PTPRJ AKT1 AKT1 ABL2 ABL2 GAB2 GAB2 SOCS6 SOCS6 UBA52 UBA52 PIK3R1 PIK3R1 GRB10 GRB10 SLA2 SLA2 GRAP2 GRAP2 SYK SYK KRAS KRAS CBL CBL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SLAUncharacterized protein. (291 aa)
CRADDUncharacterized protein. (398 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
LOC109502223Ubiquitin-like domain-containing protein. (176 aa)
ENSFCAP00000026617Ubiquitin-like domain-containing protein. (78 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
FOXO3Forkhead box O3. (672 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
FLT3LGFms related tyrosine kinase 3 ligand. (291 aa)
CSDE1Cold shock domain containing E1. (844 aa)
RPS27ARibosomal protein S27a. (156 aa)
CSKTyrosine-protein kinase. (549 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
ERASES cell expressed Ras. (233 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
SH2B3SH2B adaptor protein 3. (578 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1022 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1213 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ABL2Tyrosine-protein kinase. (1160 aa)
GAB2GRB2 associated binding protein 2. (678 aa)
SOCS6Suppressor of cytokine signaling 6. (497 aa)
UBA52Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
GRB10Growth factor receptor bound protein 10. (594 aa)
SLA2Src like adaptor 2. (262 aa)
GRAP2GRB2 related adaptor protein 2. (322 aa)
SYKSpleen associated tyrosine kinase. (636 aa)
KRASUncharacterized protein. (380 aa)
CBLCbl proto-oncogene. (902 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.