STRINGSTRING
ENSFCAP00000041080 ENSFCAP00000041080 MPP2 MPP2 FIS1 FIS1 ENSFCAP00000040280 ENSFCAP00000040280 PEX10 PEX10 GRPEL2 GRPEL2 OTOF OTOF FAM185A FAM185A CC1H1orf146 CC1H1orf146 PEX5 PEX5 GET3 GET3 APP APP EPHX4 EPHX4 SGTB SGTB TIMM17B TIMM17B PEX16 PEX16 SCP2D1 SCP2D1 C1QTNF12 C1QTNF12 PHYH PHYH PEX19 PEX19 ABCD1 ABCD1 CHCHD10 CHCHD10 BCS1L BCS1L BAG6 BAG6 CMC2 CMC2 LONP2 LONP2 COX17 COX17 GDAP1L1 GDAP1L1 HSD17B4 HSD17B4 GFER GFER PEX6 PEX6 UBA52 UBA52 SUGCT SUGCT PEX12 PEX12 OTC OTC EMD EMD LONP1 LONP1 ATP5F1B ATP5F1B SEC61B SEC61B ACBD5 ACBD5 ZFAND6 ZFAND6 ATAD1 ATAD1 GDAP1 GDAP1 HSDL2 HSDL2 TTC33 TTC33 COQ2 COQ2 PEX1 PEX1 ILVBL ILVBL STX5 STX5 TIMM44 TIMM44 SLC25A17 SLC25A17 SGTA SGTA FER1L6 FER1L6 AMACR AMACR ENSFCAP00000039745 ENSFCAP00000039745 LOC101094135 LOC101094135 ENSFCAP00000039396 ENSFCAP00000039396 NOS2 NOS2 KXD1 KXD1 CHCHD2 CHCHD2 MEST MEST DHRS2 DHRS2 PEX7 PEX7 LOC101082948 LOC101082948 TIMM9 TIMM9 SEC61G SEC61G LOC109502223 LOC109502223 ENSFCAP00000031105 ENSFCAP00000031105 PRNP PRNP MPV17 MPV17 PEX14 PEX14 ABCD3 ABCD3 UBE2D3 UBE2D3 SPIRE2 SPIRE2 TIMM10 TIMM10 USP9X USP9X ENSFCAP00000026617 ENSFCAP00000026617 NRDC NRDC ENSFCAP00000025816 ENSFCAP00000025816 CAMLG CAMLG DNAJC15 DNAJC15 AGPS AGPS DPY19L4 DPY19L4 PEX3 PEX3 TTC3 TTC3 EPHX3 EPHX3 CYB5A CYB5A M3X8J3_FELCA M3X8J3_FELCA FXN FXN UBL4A UBL4A ABCD2 ABCD2 TIMM8B TIMM8B BTBD8 BTBD8 TIMM21 TIMM21 M3X1T3_FELCA M3X1T3_FELCA TAZ TAZ CHCHD5 CHCHD5 HSPD1 HSPD1 RPS27A RPS27A PEX13 PEX13 CMC4 CMC4 COA4 COA4 DPY19L3 DPY19L3 PAOX PAOX UBE2D2 UBE2D2 NUDT7 NUDT7 DPY19L2 DPY19L2 VAPA VAPA HMOX1 HMOX1 C3orf18 C3orf18 CRAT CRAT TIMM50 TIMM50 VAMP2 VAMP2 LOC111559039 LOC111559039 ATP5MC1 ATP5MC1 ENSFCAP00000058376 ENSFCAP00000058376 PITRM1 PITRM1 PEX26 PEX26 MPV17L MPV17L SERP2 SERP2 CHCHD3 CHCHD3 TIMM17A TIMM17A LOC101098145 LOC101098145 UBL4B UBL4B PHYHD1 PHYHD1 TIMM10B TIMM10B ALDH3A2 ALDH3A2 UBE2D1 UBE2D1 ENSFCAP00000053559 ENSFCAP00000053559 SERP1 SERP1 ECH1 ECH1 ACAA1 ACAA1 CLDN15 CLDN15 PEX11G PEX11G PEX11B PEX11B DNAJC19 DNAJC19 LOC101090625 LOC101090625 MPV17L2 MPV17L2 LDHD LDHD PEX5L PEX5L UBE2J2 UBE2J2 CHCHD4 CHCHD4 GET4 GET4 ENSFCAP00000049626 ENSFCAP00000049626 TIMM13 TIMM13 MPP6 MPP6 CHCHD7 CHCHD7 GRPEL1 GRPEL1 ENSFCAP00000048291 ENSFCAP00000048291 ACOD1 ACOD1 LOC111559191 LOC111559191 CACUL1 CACUL1 HSCB HSCB MTX2 MTX2 TYSND1 TYSND1 TIMM8A TIMM8A PEX2 PEX2 NUDT19 NUDT19 ENSFCAP00000043830 ENSFCAP00000043830 TUBA8 TUBA8 TIMM22 TIMM22 NDUFB8 NDUFB8 GET1 GET1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSFCAP00000041080Uncharacterized protein. (51 aa)
MPP2Uncharacterized protein; Belongs to the MAGUK family. (569 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
ENSFCAP00000040280Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (127 aa)
PEX10Peroxisomal biogenesis factor 10. (326 aa)
GRPEL2GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family. (380 aa)
OTOFOtoferlin. (1998 aa)
FAM185AFamily with sequence similarity 185 member A. (392 aa)
CC1H1orf146Chromosome C1 C1orf146 homolog. (180 aa)
PEX5Peroxisomal biogenesis factor 5. (640 aa)
GET3ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...] (348 aa)
APPAmyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (935 aa)
EPHX4Epoxide hydrolase 4. (362 aa)
SGTBSmall glutamine rich tetratricopeptide repeat containing beta. (304 aa)
TIMM17BMitochondrial import inner membrane translocase subunit TIM17; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (172 aa)
PEX16Peroxisomal membrane protein PEX16. (404 aa)
SCP2D1SCP2 sterol binding domain containing 1. (156 aa)
C1QTNF12C1q and TNF related 12. (297 aa)
PHYHPhytanoyl-CoA 2-hydroxylase. (357 aa)
PEX19Peroxisomal biogenesis factor 19. (299 aa)
ABCD1ATP binding cassette subfamily D member 1. (733 aa)
CHCHD10Coiled-coil-helix-coiled-coil-helix domain containing 10. (237 aa)
BCS1LBCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone; Belongs to the AAA ATPase family. (419 aa)
BAG6BCL2 associated athanogene 6. (1184 aa)
CMC2COX assembly mitochondrial protein. (151 aa)
LONP2Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta- oxidation through degradation of the self-processed forms of TYSND1. (882 aa)
COX17Cytochrome c oxidase copper chaperone COX17. (63 aa)
GDAP1L1Ganglioside induced differentiation associated protein 1 like 1. (367 aa)
HSD17B4Hydroxysteroid 17-beta dehydrogenase 4. (736 aa)
GFERSulfhydryl oxidase. (408 aa)
PEX6Peroxisomal biogenesis factor 6. (980 aa)
UBA52Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
SUGCTSuccinyl-CoA:glutarate-CoA transferase. (445 aa)
PEX12Peroxisome assembly protein 12; Required for protein import into peroxisomes. Belongs to the pex2/pex10/pex12 family. (359 aa)
OTCOrnithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (354 aa)
EMDEmerin. (260 aa)
LONP1Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand- specific manner. May regulate mi [...] (960 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (528 aa)
SEC61BProtein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (96 aa)
ACBD5Acyl-CoA binding domain containing 5. (536 aa)
ZFAND6Uncharacterized protein. (208 aa)
ATAD1ATPase family AAA domain containing 1; Belongs to the AAA ATPase family. (360 aa)
GDAP1Ganglioside induced differentiation associated protein 1; Belongs to the GST superfamily. (358 aa)
HSDL2Hydroxysteroid dehydrogenase like 2. (418 aa)
TTC33Tetratricopeptide repeat domain 33. (262 aa)
COQ24-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (362 aa)
PEX1Peroxisomal biogenesis factor 1. (1255 aa)
ILVBLIlvB acetolactate synthase like; Belongs to the TPP enzyme family. (648 aa)
STX5Syntaxin 5; Belongs to the syntaxin family. (355 aa)
TIMM44Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family. (454 aa)
SLC25A17Solute carrier family 25 member 17; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
SGTASmall glutamine rich tetratricopeptide repeat containing alpha. (334 aa)
FER1L6Fer-1 like family member 6. (1869 aa)
AMACRAlpha-methylacyl-CoA racemase. (382 aa)
ENSFCAP00000039745Uncharacterized protein. (55 aa)
LOC101094135Mitochondrial import inner membrane translocase subunit TIM23; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (209 aa)
ENSFCAP00000039396Uncharacterized protein. (59 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1165 aa)
KXD1KxDL motif containing 1. (201 aa)
CHCHD2Coiled-coil-helix-coiled-coil-helix domain containing 2. (153 aa)
MESTMesoderm specific transcript. (335 aa)
DHRS2Dehydrogenase/reductase 2. (281 aa)
PEX7Peroxisomal biogenesis factor 7. (323 aa)
LOC101082948Uncharacterized protein. (79 aa)
TIMM9Translocase of inner mitochondrial membrane 9. (89 aa)
SEC61GUncharacterized protein. (68 aa)
LOC109502223Ubiquitin-like domain-containing protein. (176 aa)
ENSFCAP00000031105SH3 domain-containing protein. (373 aa)
PRNPMajor prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase deg [...] (260 aa)
MPV17Mitochondrial inner membrane protein MPV17; Belongs to the peroxisomal membrane protein PXMP2/4 family. (191 aa)
PEX14Peroxisomal biogenesis factor 14. (373 aa)
ABCD3ATP binding cassette subfamily D member 3. (674 aa)
UBE2D3Ubiquitin conjugating enzyme E2 D3; Belongs to the ubiquitin-conjugating enzyme family. (149 aa)
SPIRE2Spire type actin nucleation factor 2. (766 aa)
TIMM10Translocase of inner mitochondrial membrane 10. (90 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2554 aa)
ENSFCAP00000026617Ubiquitin-like domain-containing protein. (78 aa)
NRDCNardilysin convertase. (1226 aa)
ENSFCAP00000025816Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (145 aa)
CAMLGCalcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B. (299 aa)
DNAJC15DnaJ heat shock protein family (Hsp40) member C15. (149 aa)
AGPSAlkylglycerone-phosphate synthase; Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids; Belongs to the FAD-binding oxidoreductase/transferase type 4 family. (727 aa)
DPY19L4Dpy-19 like 4. (723 aa)
PEX3Peroxisomal biogenesis factor 3. (373 aa)
TTC3TPR_REGION domain-containing protein. (610 aa)
EPHX3Epoxide hydrolase 3. (360 aa)
CYB5ACytochrome b5 type A; Belongs to the cytochrome b5 family. (134 aa)
M3X8J3_FELCAUncharacterized protein. (68 aa)
FXNFrataxin. (211 aa)
UBL4AUbiquitin like 4A. (159 aa)
ABCD2ATP binding cassette subfamily D member 2. (739 aa)
TIMM8BTranslocase of inner mitochondrial membrane 8 homolog B; Belongs to the small Tim family. (204 aa)
BTBD8BTB domain containing 8. (1784 aa)
TIMM21Translocase of inner mitochondrial membrane 21. (244 aa)
M3X1T3_FELCACHCH domain-containing protein. (146 aa)
TAZTafazzin family protein; Some isoforms may be involved in cardiolipin metabolism. (262 aa)
CHCHD5Coiled-coil-helix-coiled-coil-helix domain containing 5. (110 aa)
HSPD1Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family. (573 aa)
RPS27ARibosomal protein S27a. (156 aa)
PEX13SH3 domain-containing protein. (403 aa)
CMC4C-X9-C motif containing 4. (68 aa)
COA4Cytochrome c oxidase assembly factor 4 homolog. (91 aa)
DPY19L3Dpy-19 like C-mannosyltransferase 3. (716 aa)
PAOXAmino_oxidase domain-containing protein. (510 aa)
UBE2D2Ubiquitin conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
NUDT7Nudix hydrolase 7. (238 aa)
DPY19L2Dpy-19 like 2. (799 aa)
VAPAVAMP associated protein A. (294 aa)
HMOX1Heme oxygenase 1. (404 aa)
C3orf18Chromosome 3 open reading frame 18. (182 aa)
CRATCarnitine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (626 aa)
TIMM50Translocase of inner mitochondrial membrane 50. (608 aa)
VAMP2V-SNARE coiled-coil homology domain-containing protein. (170 aa)
LOC111559039M16C_associated domain-containing protein. (568 aa)
ATP5MC1ATP-synt_C domain-containing protein; Belongs to the ATPase C chain family. (142 aa)
ENSFCAP00000058376Uncharacterized protein. (161 aa)
PITRM1Pitrilysin metallopeptidase 1. (1043 aa)
PEX26Peroxisomal biogenesis factor 26. (307 aa)
MPV17LUncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family. (300 aa)
SERP2Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (151 aa)
CHCHD3MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (276 aa)
TIMM17AMitochondrial import inner membrane translocase subunit TIM17; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (208 aa)
LOC101098145Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (298 aa)
UBL4BUbiquitin-like domain-containing protein. (60 aa)
PHYHD1Uncharacterized protein. (367 aa)
TIMM10Bzf-Tim10_DDP domain-containing protein. (103 aa)
ALDH3A2Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (515 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
ENSFCAP00000053559Uncharacterized protein; Belongs to the ATPase C chain family. (135 aa)
SERP1Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (76 aa)
ECH1Enoyl-CoA hydratase 1; Belongs to the enoyl-CoA hydratase/isomerase family. (380 aa)
ACAA1Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (456 aa)
CLDN15Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (226 aa)
PEX11GPeroxisomal biogenesis factor 11 gamma. (324 aa)
PEX11BPeroxisomal biogenesis factor 11 beta. (288 aa)
DNAJC19Uncharacterized protein. (144 aa)
LOC101090625AN1-type domain-containing protein. (195 aa)
MPV17L2MPV17 mitochondrial inner membrane protein like 2; Belongs to the peroxisomal membrane protein PXMP2/4 family. (217 aa)
LDHDLactate dehydrogenase D. (566 aa)
PEX5LPeroxisomal biogenesis factor 5 like. (626 aa)
UBE2J2UBIQUITIN_CONJUGAT_2 domain-containing protein. (259 aa)
CHCHD4CHCH domain-containing protein. (141 aa)
GET4Golgi to ER traffic protein 4. (648 aa)
ENSFCAP00000049626Uncharacterized protein. (300 aa)
TIMM13Translocase of inner mitochondrial membrane 13; Belongs to the small Tim family. (95 aa)
MPP6Membrane palmitoylated protein 6; Belongs to the MAGUK family. (560 aa)
CHCHD7Coiled-coil-helix-coiled-coil-helix domain containing 7. (109 aa)
GRPEL1GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family. (217 aa)
ENSFCAP00000048291Uncharacterized protein. (113 aa)
ACOD1Aconitate decarboxylase 1. (482 aa)
LOC111559191Mitochondrial import inner membrane translocase subunit Tim8 A. (97 aa)
CACUL1CDK2 associated cullin domain 1; Belongs to the cullin family. (369 aa)
HSCBHscB mitochondrial iron-sulfur cluster cochaperone. (235 aa)
MTX2Metaxin 2. (285 aa)
TYSND1Trypsin domain containing 1. (648 aa)
TIMM8Azf-Tim10_DDP domain-containing protein; Belongs to the small Tim family. (97 aa)
PEX2Peroxisomal biogenesis factor 2. (305 aa)
NUDT19Nudix hydrolase 19. (371 aa)
ENSFCAP00000043830Uncharacterized protein. (316 aa)
TUBA8Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (481 aa)
TIMM22Translocase of inner mitochondrial membrane 22. (194 aa)
NDUFB8NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (186 aa)
GET1Guided entry of tail-anchored proteins factor 1. (174 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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