20 items (Felis catus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	LOC105259631	Uncharacterized protein; Belongs to the peptidase C1 family. (259 aa)
	LOC101087880	Uncharacterized protein; Belongs to the peptidase C1 family. (333 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	RHEB	Ras homolog, mTORC1 binding. (187 aa)
	LOC101101202	Uncharacterized protein; Belongs to the peptidase C1 family. (305 aa)
	PDP	Cathepsin L1; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family. (332 aa)
	GABARAP	GABA type A receptor-associated protein. (117 aa)
	FOXO4	Forkhead box O4. (515 aa)
	LOC111559123	Uncharacterized protein; Belongs to the peptidase C1 family. (323 aa)
	CASP3	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa)
	TSC2	TSC complex subunit 2. (1806 aa)
	CTSV	Cathepsin V; Belongs to the peptidase C1 family. (333 aa)
	LOC101082891	Uncharacterized protein; Belongs to the peptidase C1 family. (328 aa)
	FOXO1	Forkhead box O1. (662 aa)
	MB	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (154 aa)
	IGF1	Insulin like growth factor 1. (195 aa)
	EIF4E	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (237 aa)
	BDNF	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (255 aa)
	AKT2	Non-specific serine/threonine protein kinase. (571 aa)
	BNIP3	BCL2 interacting protein 3. (187 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT2	AKT3	ENSFCAP00000059662	ENSFCAP00000003410	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.918
AKT2	CASP3	ENSFCAP00000059662	ENSFCAP00000031946	Non-specific serine/threonine protein kinase.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.572
AKT2	FOXO1	ENSFCAP00000059662	ENSFCAP00000039549	Non-specific serine/threonine protein kinase.	Forkhead box O1.	0.972
AKT2	FOXO4	ENSFCAP00000059662	ENSFCAP00000031271	Non-specific serine/threonine protein kinase.	Forkhead box O4.	0.967
AKT2	RHEB	ENSFCAP00000059662	ENSFCAP00000011928	Non-specific serine/threonine protein kinase.	Ras homolog, mTORC1 binding.	0.447
AKT2	TSC2	ENSFCAP00000059662	ENSFCAP00000033801	Non-specific serine/threonine protein kinase.	TSC complex subunit 2.	0.975
AKT3	AKT2	ENSFCAP00000003410	ENSFCAP00000059662	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.918
AKT3	CASP3	ENSFCAP00000003410	ENSFCAP00000031946	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.572
AKT3	FOXO1	ENSFCAP00000003410	ENSFCAP00000039549	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O1.	0.968
AKT3	FOXO4	ENSFCAP00000003410	ENSFCAP00000031271	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O4.	0.967
AKT3	RHEB	ENSFCAP00000003410	ENSFCAP00000011928	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Ras homolog, mTORC1 binding.	0.447
AKT3	TSC2	ENSFCAP00000003410	ENSFCAP00000033801	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	TSC complex subunit 2.	0.974
BDNF	CASP3	ENSFCAP00000049682	ENSFCAP00000031946	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.835
BDNF	IGF1	ENSFCAP00000049682	ENSFCAP00000042016	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Insulin like growth factor 1.	0.899
BNIP3	CASP3	ENSFCAP00000061759	ENSFCAP00000031946	BCL2 interacting protein 3.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.514
BNIP3	FOXO1	ENSFCAP00000061759	ENSFCAP00000039549	BCL2 interacting protein 3.	Forkhead box O1.	0.431
BNIP3	GABARAP	ENSFCAP00000061759	ENSFCAP00000022562	BCL2 interacting protein 3.	GABA type A receptor-associated protein.	0.964
BNIP3	RHEB	ENSFCAP00000061759	ENSFCAP00000011928	BCL2 interacting protein 3.	Ras homolog, mTORC1 binding.	0.973
CASP3	AKT2	ENSFCAP00000031946	ENSFCAP00000059662	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Non-specific serine/threonine protein kinase.	0.572
CASP3	AKT3	ENSFCAP00000031946	ENSFCAP00000003410	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.572