STRINGSTRING
LOC105259631 LOC105259631 LOC101087880 LOC101087880 AKT3 AKT3 RHEB RHEB LOC101101202 LOC101101202 PDP PDP GABARAP GABARAP FOXO4 FOXO4 LOC111559123 LOC111559123 CASP3 CASP3 TSC2 TSC2 CTSV CTSV LOC101082891 LOC101082891 FOXO1 FOXO1 MB MB IGF1 IGF1 EIF4E EIF4E BDNF BDNF AKT2 AKT2 BNIP3 BNIP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC105259631Uncharacterized protein; Belongs to the peptidase C1 family. (259 aa)
LOC101087880Uncharacterized protein; Belongs to the peptidase C1 family. (333 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RHEBRas homolog, mTORC1 binding. (187 aa)
LOC101101202Uncharacterized protein; Belongs to the peptidase C1 family. (305 aa)
PDPCathepsin L1; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family. (332 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
FOXO4Forkhead box O4. (515 aa)
LOC111559123Uncharacterized protein; Belongs to the peptidase C1 family. (323 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa)
TSC2TSC complex subunit 2. (1806 aa)
CTSVCathepsin V; Belongs to the peptidase C1 family. (333 aa)
LOC101082891Uncharacterized protein; Belongs to the peptidase C1 family. (328 aa)
FOXO1Forkhead box O1. (662 aa)
MBMyoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (154 aa)
IGF1Insulin like growth factor 1. (195 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (237 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (255 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
BNIP3BCL2 interacting protein 3. (187 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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