40 items (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ITGA1	Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1179 aa)
	COL1A1	Collagen type I alpha 1 chain. (1461 aa)
	TRAF4	TNF receptor-associated factor. (470 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	BMP2	Bone morphogenetic protein 2. (395 aa)
	FGF11	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (290 aa)
	FGF12	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	IGF1	Insulin like growth factor 1. (195 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
	FGF14	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (303 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (170 aa)
	RUNX2	RUNX family transcription factor 2. (584 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (326 aa)
	FGF3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (229 aa)
	FGF5	Fibroblast growth factor 5. (279 aa)
	LOC111559734	Bone morphogenetic protein 7. (426 aa)
	FGF17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (285 aa)
	FGF22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (271 aa)
	SMAD2	Mothers against decapentaplegic homolog. (721 aa)
	CXCL12	Stromal cell-derived factor 1; Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4 [...] (143 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (556 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	DCN	Decorin; May affect the rate of fibrils formation. (360 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	FGF16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	FGF13	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (274 aa)
	FBN1	Fibrillin 1. (2871 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	CA4	Carbonic anhydrase 4; Belongs to the alpha-carbonic anhydrase family. (313 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	VTN	SMB domain-containing protein. (468 aa)
	FGF21	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP2	BMP4	ENSFCAP00000031036	ENSFCAP00000051185	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.932
BMP2	COL1A1	ENSFCAP00000031036	ENSFCAP00000004218	Bone morphogenetic protein 2.	Collagen type I alpha 1 chain.	0.564
BMP2	FGF1	ENSFCAP00000031036	ENSFCAP00000051521	Bone morphogenetic protein 2.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.493
BMP2	FGF10	ENSFCAP00000031036	ENSFCAP00000032796	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.565
BMP2	FGF11	ENSFCAP00000031036	ENSFCAP00000025550	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.518
BMP2	FGF12	ENSFCAP00000031036	ENSFCAP00000022761	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.571
BMP2	FGF13	ENSFCAP00000031036	ENSFCAP00000017042	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.513
BMP2	FGF14	ENSFCAP00000031036	ENSFCAP00000035814	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.571
BMP2	FGF16	ENSFCAP00000031036	ENSFCAP00000017409	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.572
BMP2	FGF17	ENSFCAP00000031036	ENSFCAP00000054041	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.571
BMP2	FGF18	ENSFCAP00000031036	ENSFCAP00000048240	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.654
BMP2	FGF19	ENSFCAP00000031036	ENSFCAP00000039774	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.568
BMP2	FGF20	ENSFCAP00000031036	ENSFCAP00000044140	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.572
BMP2	FGF21	ENSFCAP00000031036	ENSFCAP00000006832	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.565
BMP2	FGF22	ENSFCAP00000031036	ENSFCAP00000054775	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.571
BMP2	FGF3	ENSFCAP00000031036	ENSFCAP00000046878	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.570
BMP2	FGF4	ENSFCAP00000031036	ENSFCAP00000032906	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.618
BMP2	FGF5	ENSFCAP00000031036	ENSFCAP00000045130	Bone morphogenetic protein 2.	Fibroblast growth factor 5.	0.568
BMP2	FGF6	ENSFCAP00000031036	ENSFCAP00000000129	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.571
BMP2	FGF7	ENSFCAP00000031036	ENSFCAP00000018919	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.575