STRINGSTRING
IL1B IL1B CKM CKM CKMT2 CKMT2 CKB CKB VCAM1 VCAM1 GPX5 GPX5 GPX8 GPX8 IL6 IL6 GPX4 GPX4 PNLIPRP3 PNLIPRP3 SOD2 SOD2 ALB ALB GPX1 GPX1 VGF VGF GPX2 GPX2 GPX3 GPX3 NGF NGF CKMT1A CKMT1A BDNF BDNF GPX6 GPX6 PNLIPRP1 PNLIPRP1 BCL2 BCL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
CKMCreatine kinase, M-type; Belongs to the ATP:guanido phosphotransferase family. (424 aa)
CKMT2Creatine kinase, mitochondrial 2; Belongs to the ATP:guanido phosphotransferase family. (443 aa)
CKBCreatine kinase B; Belongs to the ATP:guanido phosphotransferase family. (480 aa)
VCAM1Vascular cell adhesion molecule 1. (748 aa)
GPX5Glutathione peroxidase; Belongs to the glutathione peroxidase family. (222 aa)
GPX8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa)
GPX4Glutathione peroxidase; Belongs to the glutathione peroxidase family. (196 aa)
PNLIPRP3Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (473 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (618 aa)
GPX1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (205 aa)
VGFVGF nerve growth factor inducible. (616 aa)
GPX2Glutathione peroxidase; Belongs to the glutathione peroxidase family. (189 aa)
GPX3Glutathione peroxidase; Belongs to the glutathione peroxidase family. (225 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (259 aa)
CKMT1AUncharacterized protein; Belongs to the ATP:guanido phosphotransferase family. (539 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (255 aa)
GPX6Glutathione peroxidase; Belongs to the glutathione peroxidase family. (221 aa)
PNLIPRP1Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (495 aa)
BCL2BCL2 apoptosis regulator. (237 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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