STRINGSTRING
MTOR MTOR CTSK CTSK OVCH1 OVCH1 RELA RELA ATG5 ATG5 TERT TERT BCL2 BCL2 ATG3 ATG3 HDAC6 HDAC6 ATG7 ATG7 PXDN PXDN NBR1 NBR1 ALB ALB LOC101096371 LOC101096371 DNAJB1 DNAJB1 HSPB8 HSPB8 BAG3 BAG3 CDK4 CDK4 LOC101096125 LOC101096125 BECN1 BECN1 CTRL CTRL ULK1 ULK1 ATG12 ATG12 PXDNL PXDNL VCP VCP FLNC FLNC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa)
CTSKCathepsin S; Belongs to the peptidase C1 family. (445 aa)
OVCH1Uncharacterized protein; Belongs to the peptidase S1 family. (1450 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1302 aa)
BCL2BCL2 apoptosis regulator. (237 aa)
ATG3Autophagy-related protein 3. (333 aa)
HDAC6Histone deacetylase 6. (1178 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (752 aa)
PXDNPeroxidasin. (1502 aa)
NBR1NBR1 autophagy cargo receptor. (968 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (618 aa)
LOC101096371Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (263 aa)
DNAJB1DnaJ heat shock protein family (Hsp40) member B1. (340 aa)
HSPB8Heat shock protein family B (small) member 8; Belongs to the small heat shock protein (HSP20) family. (196 aa)
BAG3BCL2 associated athanogene 3. (565 aa)
CDK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa)
LOC101096125Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (264 aa)
BECN1Beclin 1. (448 aa)
CTRLChymotrypsin like; Belongs to the peptidase S1 family. (264 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1113 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
PXDNLPeroxidasin like. (1457 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (761 aa)
FLNCFilamin C. (2719 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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