27 items (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AMPH	Amphiphysin. (856 aa)
	BCL2	BCL2 apoptosis regulator. (237 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (606 aa)
	AMBRA1	Autophagy and beclin 1 regulator 1. (1301 aa)
	KEAP1	Kelch like ECH associated protein 1. (624 aa)
	BECN1	Beclin 1. (448 aa)
	IL10	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
	EPAS1	Endothelial PAS domain protein 1. (872 aa)
	KRAS	Uncharacterized protein. (380 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	ALDH3B1	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (489 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
	CASP3	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa)
	BIN1	Bridging integrator 1. (608 aa)
	SRC	Tyrosine-protein kinase. (678 aa)
	EGFR	Receptor protein-tyrosine kinase. (1209 aa)
	ACR	Acrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome. (423 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	MMP9	Matrix metallopeptidase 9. (705 aa)
	ULK1	Unc-51 like autophagy activating kinase 1. (1113 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
	EPO	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. (192 aa)
	ALDH3A1	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (478 aa)
	E2F1	E2F transcription factor 1. (436 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	ALDH3A2	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (515 aa)
	UVRAG	UV radiation resistance associated. (718 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH3A1	ALDH3B1	ENSFCAP00000004809	ENSFCAP00000018094	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.903
ALDH3B1	ALDH3A1	ENSFCAP00000018094	ENSFCAP00000004809	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.903
AMBRA1	ATG12	ENSFCAP00000012643	ENSFCAP00000007041	Autophagy and beclin 1 regulator 1.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.582
AMBRA1	ATG5	ENSFCAP00000012643	ENSFCAP00000046882	Autophagy and beclin 1 regulator 1.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.612
AMBRA1	BCL2	ENSFCAP00000012643	ENSFCAP00000062072	Autophagy and beclin 1 regulator 1.	BCL2 apoptosis regulator.	0.452
AMBRA1	BECN1	ENSFCAP00000012643	ENSFCAP00000012183	Autophagy and beclin 1 regulator 1.	Beclin 1.	0.999
AMBRA1	PIK3C3	ENSFCAP00000012643	ENSFCAP00000025540	Autophagy and beclin 1 regulator 1.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.990
AMBRA1	ULK1	ENSFCAP00000012643	ENSFCAP00000010015	Autophagy and beclin 1 regulator 1.	Unc-51 like autophagy activating kinase 1.	0.976
AMBRA1	UVRAG	ENSFCAP00000012643	ENSFCAP00000056901	Autophagy and beclin 1 regulator 1.	UV radiation resistance associated.	0.947
AMPH	BIN1	ENSFCAP00000060611	ENSFCAP00000037575	Amphiphysin.	Bridging integrator 1.	0.997
AMPH	SRC	ENSFCAP00000060611	ENSFCAP00000041142	Amphiphysin.	Tyrosine-protein kinase.	0.515
ATG12	AMBRA1	ENSFCAP00000007041	ENSFCAP00000012643	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy and beclin 1 regulator 1.	0.582
ATG12	ATG5	ENSFCAP00000007041	ENSFCAP00000046882	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG12	BCL2	ENSFCAP00000007041	ENSFCAP00000062072	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	BCL2 apoptosis regulator.	0.696
ATG12	BECN1	ENSFCAP00000007041	ENSFCAP00000012183	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Beclin 1.	0.981
ATG12	CASP3	ENSFCAP00000007041	ENSFCAP00000031946	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.524
ATG12	EGFR	ENSFCAP00000007041	ENSFCAP00000041464	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Receptor protein-tyrosine kinase.	0.422
ATG12	PIK3C3	ENSFCAP00000007041	ENSFCAP00000025540	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.813
ATG12	ULK1	ENSFCAP00000007041	ENSFCAP00000010015	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Unc-51 like autophagy activating kinase 1.	0.911
ATG12	UVRAG	ENSFCAP00000007041	ENSFCAP00000056901	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	UV radiation resistance associated.	0.661