STRINGSTRING
IFNG IFNG AREG AREG IL4 IL4 CCR8 CCR8 ALPL ALPL CSF2 CSF2 CD4 CD4 IFNB1 IFNB1 CCL17 CCL17 ICOS ICOS TNFRSF4 TNFRSF4 TNFSF4 TNFSF4 IL5 IL5 STAT5A STAT5A ALPI ALPI PDCD1 PDCD1 CXCL10 CXCL10 CCL26 CCL26 C5AR1 C5AR1 IFNGR2 IFNGR2 CCL22 CCL22 MYD88 MYD88 IL13 IL13 IL17A IL17A CD40LG CD40LG IL13RA2 IL13RA2 CXCR2 CXCR2 IFNAR1 IFNAR1 TLR4 TLR4 IL6 IL6 IL13RA1 IL13RA1 TLR2 TLR2 MMP9 MMP9 IL9 IL9 IL10 IL10 CSF3R CSF3R TSLP TSLP CD80 CD80 ICAM1 ICAM1 IL33 IL33 IL2RA IL2RA IL1B IL1B NFKBIA NFKBIA ADRB2 ADRB2 IL1A IL1A NOD2 NOD2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
AREGAmphiregulin. (323 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (134 aa)
CCR8C-C motif chemokine receptor 8; Belongs to the G-protein coupled receptor 1 family. (355 aa)
ALPLAlkaline phosphatase, tissue-nonspecific isozyme; This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi); Belongs to the alkaline phosphatase family. (524 aa)
CSF2Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (142 aa)
CD4CD4 molecule. (487 aa)
IFNB1Interferon beta; Has antiviral, antibacterial and anticancer activities. (186 aa)
CCL17C-C motif chemokine 17; Chemotactic factor for t lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 and CCR8 (By similarity). (99 aa)
ICOSInducible T cell costimulator. (247 aa)
TNFRSF4TNF receptor superfamily member 4. (350 aa)
TNFSF4Tumor necrosis factor ligand 2B; Belongs to the tumor necrosis factor family. (295 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
ALPIAlkaline phosphatase. (561 aa)
PDCD1Programmed cell death 1. (278 aa)
CXCL10C-X-C motif chemokine. (98 aa)
CCL26C-C motif chemokine. (94 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (351 aa)
IFNGR2Interferon gamma receptor 2. (390 aa)
CCL22C-C motif chemokine. (93 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (308 aa)
IL13Interleukin 13. (144 aa)
IL17AInterleukin 17A. (155 aa)
CD40LGCD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (260 aa)
IL13RA2Interleukin 13 receptor subunit alpha 2. (433 aa)
CXCR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (401 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (562 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa)
IL13RA1Interleukin 13 receptor subunit alpha 1. (427 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (784 aa)
MMP9Matrix metallopeptidase 9. (705 aa)
IL9Interleukin 9. (141 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
CSF3RColony stimulating factor 3 receptor. (839 aa)
TSLPThymic stromal lymphopoietin. (224 aa)
CD80B-lymphocyte activation antigen B7-1 (CD80). (292 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
IL33Interleukin 33. (268 aa)
IL2RAInterleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (275 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
ADRB2Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine (By similarity). Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily. (418 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1014 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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