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| | DRD2 | Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (511 aa) |
| | TET2 | Tet_JBP domain-containing protein. (241 aa) |
| | CASP6 | Caspase 6; Belongs to the phospholipase A2 family. (431 aa) |
| | ACSL5 | Acyl-CoA synthetase long chain family member 5. (670 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (312 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa) |
| | BCAT1 | Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (457 aa) |
| | SRSF2 | RRM domain-containing protein. (221 aa) |
| | U2AF1 | Uncharacterized protein. (240 aa) |
| | JAK2 | Tyrosine-protein kinase. (1131 aa) |
| | STAG2 | Stromal antigen 2. (1268 aa) |
| | CDK6 | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (338 aa) |
| | CD38 | CD38 molecule. (307 aa) |
| | CCNT1 | CYCLIN domain-containing protein; Belongs to the cyclin family. (184 aa) |
| | CHEK2 | Checkpoint kinase 2. (569 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1250 aa) |
| | CEBPA | CCAAT enhancer binding protein alpha. (359 aa) |
| | ANGPT1 | Angiopoietin 1. (498 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa) |
| | CBFB | Uncharacterized protein. (187 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (215 aa) |
| | BCL2L2 | BCL2 like 2. (193 aa) |
| | ZNF384 | Zinc finger protein 384. (759 aa) |
| | BRD4 | Bromodomain containing 4. (1361 aa) |
| | PKLR | Pyruvate kinase; Belongs to the pyruvate kinase family. (634 aa) |
| | MBNL1 | Muscleblind like splicing regulator 1. (399 aa) |
| | WT1 | WT1 transcription factor. (523 aa) |
| | BTK | Tyrosine-protein kinase. (692 aa) |
| | SPHK2 | DAGKc domain-containing protein. (660 aa) |
| | KMT2A | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (3997 aa) |
| | CCND2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa) |
| | LDHA | L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa) |
| | PIK3R4 | Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa) |
| | ACSL6 | AMP-binding domain-containing protein. (722 aa) |
| | FIS1 | Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa) |
| | ZBTB7A | Zinc finger and BTB domain containing 7A. (584 aa) |
| | ATG7 | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (752 aa) |
| | SF3B1 | Splicing factor 3b subunit 1. (1308 aa) |
| | HMGCR | 3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa) |
| | TET2-2 | Tet methylcytosine dioxygenase 2. (1167 aa) |
| | LOC101098213 | Cytochrome c. (105 aa) |
| | PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa) |
| | RARA | Retinoic acid receptor alpha. (462 aa) |
| | DEK | DEK proto-oncogene. (377 aa) |
| | GLS | Glutaminase. (672 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | PPM1K | Protein phosphatase, Mg2+/Mn2+ dependent 1K. (372 aa) |
| | ACSL4 | Acyl-CoA synthetase long chain family member 4. (711 aa) |
| | FASLG | Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa) |
| | HLX | H2.0 like homeobox. (569 aa) |
| | CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa) |
| | MEIS1 | Meis homeobox 1. (465 aa) |
| | RUNX1T1 | RUNX1 partner transcriptional co-repressor 1. (615 aa) |
| | BCOR | BCL6 corepressor. (1802 aa) |
| | PTPN11 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa) |
| | RPS6KA3 | Ribosomal protein S6 kinase. (740 aa) |
| | CDK9 | Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (492 aa) |
| | ATG4C | Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (458 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (712 aa) |
| | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity). (350 aa) |
| | LOC101100947 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | NPM1 | Nucleophosmin 1. (294 aa) |
| | DMAC2L | Uncharacterized protein. (200 aa) |
| | PSAT1 | Phosphoserine aminotransferase. (370 aa) |
| | PPID | Peptidylprolyl isomerase D. (370 aa) |
| | CDKN1A | Cyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa) |
| | TOP2B | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1621 aa) |
| | ETV6 | ETS variant 6. (429 aa) |
| | PIM2 | Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (311 aa) |
| | NOTCH1 | Notch receptor 1. (2543 aa) |
| | ELF1 | E74 like ETS transcription factor 1. (619 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (451 aa) |
| | DHODH | Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (395 aa) |
| | ATG14 | Autophagy related 14. (510 aa) |
| | LOC101081229 | Pyruvate kinase; Belongs to the pyruvate kinase family. (353 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | KRAS | Uncharacterized protein. (380 aa) |
| | ZEB2 | Zinc finger E-box binding homeobox 2. (1217 aa) |
| | MDM4 | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (491 aa) |
| | ARG2 | Arginase. (354 aa) |
| | AMBRA1 | Autophagy and beclin 1 regulator 1. (1301 aa) |
| | MARF1 | Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1980 aa) |
| | ATG9B | Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (920 aa) |
| | BECN1 | Beclin 1. (448 aa) |
| | SLC7A5 | Solute carrier family 7 member 5. (509 aa) |
| | XIAP | X-linked inhibitor of apoptosis. (454 aa) |
| | ACSL3 | Acyl-CoA synthetase long chain family member 3. (720 aa) |
| | FASN | Fatty acid synthase. (2655 aa) |
| | ATG9A | Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (998 aa) |
| | SMC3 | Structural maintenance of chromosomes protein. (1217 aa) |
| | TOP2A | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1534 aa) |
| | DHX15 | DEAH-box helicase 15. (766 aa) |
| | ATAD3A | ATPase family AAA domain containing 3A. (584 aa) |
| | EZH2 | Enhancer of zeste 2 polycomb repressive complex 2 subunit. (460 aa) |
| | GFER | Sulfhydryl oxidase. (408 aa) |
| | HTR1B | 5-hydroxytryptamine receptor 1B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopami [...] (389 aa) |
| | ATG12 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa) |
| | BCAT2 | Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (404 aa) |
| | RUNX1 | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (493 aa) |
| | GATA2 | GATA binding protein 2. (480 aa) |
| | COX17 | Cytochrome c oxidase copper chaperone COX17. (63 aa) |
| | ATOX1 | Antioxidant 1 copper chaperone. (68 aa) |
| | HK2 | Hexokinase 2. (917 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa) |
| | IGFBP1 | Insulin like growth factor binding protein 1. (247 aa) |
| | SLC1A5 | Amino acid transporter. (541 aa) |
| | RIPK3 | Receptor interacting serine/threonine kinase 3. (509 aa) |
| | NEDD8 | NEDD8 ubiquitin like modifier. (81 aa) |
| | HEXIM1 | HEXIM P-TEFb complex subunit 1. (359 aa) |
| | ACSL1 | Acyl-CoA synthetase long chain family member 1. (698 aa) |
| | HK1 | Hexokinase 1. (1056 aa) |
| | HKDC1 | Hexokinase domain containing 1. (917 aa) |
| | CDK7 | Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa) |
| | FLT3 | Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1022 aa) |
| | ASXL2 | ASXL transcriptional regulator 2. (1448 aa) |
| | CYBB | Cytochrome b-245 beta chain. (570 aa) |
| | HK3 | Hexokinase 3. (924 aa) |
| | ASXL1 | ASXL transcriptional regulator 1. (1545 aa) |
| | MYB | MYB proto-oncogene, transcription factor. (761 aa) |
| | PINK1 | PTEN induced kinase 1. (581 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa) |
| | ATG4A | Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (400 aa) |
| | BCL2 | BCL2 apoptosis regulator. (237 aa) |
| | CD34 | CD34 molecule. (406 aa) |
| | NUP214 | Nucleoporin 214. (1521 aa) |
| | CXCL12 | Stromal cell-derived factor 1; Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4 [...] (143 aa) |
| | PTCD1 | PPR_long domain-containing protein. (745 aa) |
| | ATG4B | Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (578 aa) |
| | ATG4D | Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (475 aa) |
| | CASP7 | Caspase 7; Belongs to the peptidase C14A family. (409 aa) |
| | BOK | BCL2 family apoptosis regulator BOK. (320 aa) |
| | UVRAG | UV radiation resistance associated. (718 aa) |
| | ARG1 | Arginase. (329 aa) |
| | CCNT2 | Cyclin T2; Belongs to the cyclin family. (742 aa) |
| | NF1 | Neurofibromin 1. (2856 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (479 aa) |
