STRINGSTRING
IGF2R IGF2R IGFBP3 IGFBP3 FOS FOS KERA KERA CLOCK CLOCK VDAC1 VDAC1 IGF2 IGF2 IGFBP5 IGFBP5 IGFBP2 IGFBP2 INSR INSR ZEB1 ZEB1 IRS1 IRS1 ALDH3B1 ALDH3B1 IGF1R IGF1R LMNA LMNA PAPPA PAPPA ALDH1A1 ALDH1A1 PAPPA2 PAPPA2 IGFBP1 IGFBP1 ALDH3A1 ALDH3A1 ALDH3A2 ALDH3A2 PINK1 PINK1 IGFBP6 IGFBP6 MTOR MTOR BNIP3 BNIP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IGF2RInsulin like growth factor 2 receptor. (2497 aa)
IGFBP3Insulin like growth factor binding protein 3. (299 aa)
FOSProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa)
KERAKeratocan. (350 aa)
CLOCKClock circadian regulator. (899 aa)
VDAC1Voltage dependent anion channel 1. (283 aa)
IGF2Insulin like growth factor 2. (280 aa)
IGFBP5Insulin like growth factor binding protein 5. (282 aa)
IGFBP2Insulin like growth factor binding protein 2. (330 aa)
INSRTyrosine-protein kinase receptor. (1381 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1125 aa)
IRS1Insulin receptor substrate 1. (1234 aa)
ALDH3B1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (489 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (664 aa)
PAPPAPappalysin 1. (1629 aa)
ALDH1A1Aldehyde dehydrogenase 1 family member A1; Belongs to the aldehyde dehydrogenase family. (501 aa)
PAPPA2Pappalysin 2. (1726 aa)
IGFBP1Insulin like growth factor binding protein 1. (247 aa)
ALDH3A1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (478 aa)
ALDH3A2Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (515 aa)
PINK1PTEN induced kinase 1. (581 aa)
IGFBP6Insulin like growth factor binding protein 6. (268 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa)
BNIP3BCL2 interacting protein 3. (187 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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