STRINGSTRING
HMOX1 HMOX1 BCL2 BCL2 LOC109498011 LOC109498011 CXCR4 CXCR4 LBP LBP IDO2 IDO2 FUCA1 FUCA1 FUCA2 FUCA2 SIRT3 SIRT3 NFATC1 NFATC1 GPX6 GPX6 CSAD CSAD HSF2 HSF2 SOX4 SOX4 CCND1 CCND1 KLF2 KLF2 YES1 YES1 ANGPT1 ANGPT1 POU2F1 POU2F1 SRC SRC LRG1 LRG1 TXN TXN GPX3 GPX3 GPX2 GPX2 CCR7 CCR7 LOC101095098 LOC101095098 CYP2E2 CYP2E2 CELF1 CELF1 NOS2 NOS2 FASLG FASLG TGFB2 TGFB2 GPX1 GPX1 CASP3 CASP3 ITGB1 ITGB1 MPO MPO CASP9 CASP9 CLDN5 CLDN5 FOXA1 FOXA1 GPX8 GPX8 RND3 RND3 AFP AFP GOT1 GOT1 IL6 IL6 GPX4 GPX4 CPEB2 CPEB2 RFX7 RFX7 GOT2 GOT2 DLX2 DLX2 SOD2 SOD2 TJP1 TJP1 SIRT1 SIRT1 TWIST1 TWIST1 ALB ALB ZEB1 ZEB1 MMP9 MMP9 ADIPOQ ADIPOQ IL2 IL2 IL10 IL10 NOS3 NOS3 PDCD4 PDCD4 IFNG IFNG OCLN OCLN CALCR CALCR NLK NLK GAPDH GAPDH GAPDHS GAPDHS NRP1 NRP1 IL1B IL1B TGFB1 TGFB1 CD4 CD4 IDO1 IDO1 FAAH FAAH HIF1A HIF1A IL4 IL4 STAT3 STAT3 HOXB7 HOXB7 TXN2 TXN2 CCL2 CCL2 GPX5 GPX5 SP1 SP1 PTEN PTEN ZEB2 ZEB2 TGFB3 TGFB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HMOX1Heme oxygenase 1. (404 aa)
BCL2BCL2 apoptosis regulator. (237 aa)
LOC109498011Uncharacterized protein. (483 aa)
CXCR4C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (400 aa)
LBPLipopolysaccharide binding protein. (497 aa)
IDO2Indoleamine 2,3-dioxygenase 2. (410 aa)
FUCA1Alpha-L-fucosidase 1. (721 aa)
FUCA2Alpha-L-fucosidase 2. (470 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (417 aa)
NFATC1Nuclear factor of activated T cells 1. (1085 aa)
GPX6Glutathione peroxidase; Belongs to the glutathione peroxidase family. (221 aa)
CSADCysteine sulfinic acid decarboxylase. (540 aa)
HSF2Heat shock transcription factor 2. (535 aa)
SOX4Transcription factor SOX. (459 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (312 aa)
KLF2Kruppel like factor 2. (362 aa)
YES1Tyrosine-protein kinase. (546 aa)
ANGPT1Angiopoietin 1. (498 aa)
POU2F1POU domain protein. (756 aa)
SRCTyrosine-protein kinase. (678 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (346 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
GPX3Glutathione peroxidase; Belongs to the glutathione peroxidase family. (225 aa)
GPX2Glutathione peroxidase; Belongs to the glutathione peroxidase family. (189 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
LOC101095098Uncharacterized protein. (617 aa)
CYP2E2Uncharacterized protein; Belongs to the cytochrome P450 family. (495 aa)
CELF1CUGBP Elav-like family member 1. (514 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1165 aa)
FASLGTumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
GPX1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (205 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (801 aa)
MPOMyeloperoxidase. (720 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (451 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
FOXA1Forkhead box A1. (536 aa)
GPX8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
RND3Rho family GTPase 3. (244 aa)
AFPAlpha fetoprotein. (609 aa)
GOT1Aspartate aminotransferase. (413 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa)
GPX4Glutathione peroxidase; Belongs to the glutathione peroxidase family. (196 aa)
CPEB2Cytoplasmic polyadenylation element binding protein 2. (1045 aa)
RFX7Regulatory factor X7. (1369 aa)
GOT2Aspartate aminotransferase. (430 aa)
DLX2Distal-less homeobox 2. (331 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (2008 aa)
SIRT1Sirtuin 1. (745 aa)
TWIST1Twist family bHLH transcription factor 1. (200 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (618 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1125 aa)
MMP9Matrix metallopeptidase 9. (705 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (283 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
PDCD4Programmed cell death 4. (469 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (521 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (483 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
GAPDHSGlyceraldehyde-3-phosphate dehydrogenase. (405 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CD4CD4 molecule. (487 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (407 aa)
FAAHFatty acid amide hydrolase. (579 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (825 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (134 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
HOXB7Homeobox B7. (217 aa)
TXN2Thioredoxin 2. (163 aa)
CCL2C-C motif chemokine. (99 aa)
GPX5Glutathione peroxidase; Belongs to the glutathione peroxidase family. (222 aa)
SP1Sp1 transcription factor. (786 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ZEB2Zinc finger E-box binding homeobox 2. (1217 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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