STRINGSTRING
ATM ATM MTOR MTOR CYP1A2 CYP1A2 POU5F1 POU5F1 NANOG NANOG CTNNA1 CTNNA1 CLDN18 CLDN18 STAT3 STAT3 IL4 IL4 IL1B IL1B HFE HFE CCK CCK PLCE1 PLCE1 OCLN OCLN LGR5 LGR5 EZH2 EZH2 IRAK1 IRAK1 ATG16L1 ATG16L1 GAST GAST TET1 TET1 CHAC1 CHAC1 NOS3 NOS3 PGK1 PGK1 IL10 IL10 STK11 STK11 S100A4 S100A4 ARG2 ARG2 MMP7 MMP7 FGFR4 FGFR4 PTEN PTEN RHOA RHOA CYP19A1 CYP19A1 CDX2 CDX2 BRCA2 BRCA2 TLR2 TLR2 H3F3A H3F3A IL6 IL6 GPX4 GPX4 ERBB2 ERBB2 ALDH2 ALDH2 LOC101100947 LOC101100947 CLDN8 CLDN8 TLR4 TLR4 TCEB2 TCEB2 CDX1 CDX1 RUNX3 RUNX3 SOD2 SOD2 TWIST1 TWIST1 ALB ALB ELOC ELOC LOC101098462 LOC101098462 CAV1 CAV1 TMEFF2 TMEFF2 LOC101080399 LOC101080399 ENSFCAP00000032324 ENSFCAP00000032324 GPX1 GPX1 IL17A IL17A M3X7H5_FELCA M3X7H5_FELCA LOC101098213 LOC101098213 NOS2 NOS2 NOD1 NOD1 PALB2 PALB2 GPX3 GPX3 ELOB ELOB HIST2H3C HIST2H3C LOC105260541 LOC105260541 SRC SRC MB MB EGFR EGFR PKM PKM LOX LOX LDHA LDHA ENSFCAP00000043372 ENSFCAP00000043372 MSR1 MSR1 IGFBP3 IGFBP3 CD44 CD44 JAK2 JAK2 YAP1 YAP1 IL1RN IL1RN ARHGAP6 ARHGAP6 FOXD3 FOXD3 CSK CSK CCND1 CCND1 TRAF1 TRAF1 MGMT MGMT USF2 USF2 CCN2 CCN2 CP CP GPX6 GPX6 MUC1 MUC1 ARG1 ARG1 USF1 USF1 SIRT3 SIRT3 ETV4 ETV4 SDHB SDHB EGF EGF LATS2 LATS2 CXCL12 CXCL12 CXCR4 CXCR4 CDKN2A CDKN2A TXNRD1 TXNRD1 BCL2 BCL2 TFF2 TFF2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa)
CYP1A2Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] (512 aa)
POU5F1POU domain protein. (360 aa)
NANOGNanog homeobox. (311 aa)
CTNNA1Catenin alpha 1. (927 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (134 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (362 aa)
CCKCholecystokinin. (115 aa)
PLCE1Phosphoinositide phospholipase C. (2301 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (521 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (907 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (460 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (724 aa)
ATG16L1Autophagy related 16 like 1. (623 aa)
GASTBig gastrin; Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine; Belongs to the gastrin/cholecystokinin family. (104 aa)
TET1Tet methylcytosine dioxygenase 1. (2142 aa)
CHAC1Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (222 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
PGK1Phosphoglycerate kinase. (454 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (439 aa)
S100A4Protein S100; Belongs to the S-100 family. (133 aa)
ARG2Arginase. (354 aa)
MMP7Matrilysin; Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase; Belongs to the peptidase M10A family. (267 aa)
FGFR4Fibroblast growth factor receptor. (830 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
RHOARas homolog family member A. (193 aa)
CYP19A1Cytochrome P450 family 19 subfamily A polypeptide 1 transcript variant 1; Belongs to the cytochrome P450 family. (506 aa)
CDX2Caudal type homeobox 2. (313 aa)
BRCA2Breast cancer type 2 susceptibility protein homolog; Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51- ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint acti [...] (3375 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (784 aa)
H3F3AHistone H3; Belongs to the histone H3 family. (136 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa)
GPX4Glutathione peroxidase; Belongs to the glutathione peroxidase family. (196 aa)
ERBB2Receptor protein-tyrosine kinase. (1308 aa)
ALDH2Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (517 aa)
LOC101100947Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CLDN8Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (227 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa)
TCEB2Transcription elongation factor B polypeptide 2. (118 aa)
CDX1Caudal type homeobox 1. (263 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (426 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
TWIST1Twist family bHLH transcription factor 1. (200 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (618 aa)
ELOCTranscription elongation factor B polypeptide 1; Belongs to the SKP1 family. (112 aa)
LOC101098462Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (115 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
TMEFF2Transmembrane protein with EGF like and two follistatin like domains 2. (394 aa)
LOC101080399Uncharacterized protein; Belongs to the multicopper oxidase family. (1041 aa)
ENSFCAP00000032324Histone H3; Belongs to the histone H3 family. (106 aa)
GPX1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (205 aa)
IL17AInterleukin 17A. (155 aa)
M3X7H5_FELCAHistone H3; Belongs to the histone H3 family. (112 aa)
LOC101098213Cytochrome c. (105 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1165 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
PALB2Partner and localizer of BRCA2. (1183 aa)
GPX3Glutathione peroxidase; Belongs to the glutathione peroxidase family. (225 aa)
ELOBElongin B. (202 aa)
HIST2H3CHistone cluster 2 H3 family member c. (258 aa)
LOC105260541Histone H3; Belongs to the histone H3 family. (136 aa)
SRCTyrosine-protein kinase. (678 aa)
MBMyoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (154 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
PKMPyruvate kinase PKM; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (By similarity). Stimulates POU5F1-mediated transcriptional activation (By similarity). Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages (By similarity). (531 aa)
LOXLysyl oxidase. (415 aa)
LDHAL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
ENSFCAP00000043372Histone H3; Belongs to the histone H3 family. (136 aa)
MSR1Macrophage scavenger receptor 1. (454 aa)
IGFBP3Insulin like growth factor binding protein 3. (299 aa)
CD44CD44 molecule (Indian blood group). (741 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
YAP1Yes associated protein 1. (498 aa)
IL1RNInterleukin-1. (182 aa)
ARHGAP6Rho GTPase activating protein 6. (455 aa)
FOXD3Forkhead box D3. (481 aa)
CSKTyrosine-protein kinase. (549 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (312 aa)
TRAF1TNF receptor-associated factor. (433 aa)
MGMTUncharacterized protein. (290 aa)
USF2Upstream transcription factor 2, c-fos interacting. (367 aa)
CCN2Cellular communication network factor 2. (477 aa)
CPCeruloplasmin; Belongs to the multicopper oxidase family. (1542 aa)
GPX6Glutathione peroxidase; Belongs to the glutathione peroxidase family. (221 aa)
MUC1Uncharacterized protein. (931 aa)
ARG1Arginase. (329 aa)
USF1Upstream transcription factor 1. (444 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (417 aa)
ETV4ETS variant 4. (488 aa)
SDHBSuccinate dehydrogenase complex iron sulfur subunit B. (307 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1213 aa)
LATS2Non-specific serine/threonine protein kinase. (1095 aa)
CXCL12Stromal cell-derived factor 1; Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4 [...] (143 aa)
CXCR4C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (400 aa)
CDKN2AUncharacterized protein. (196 aa)
TXNRD1Thioredoxin reductase 1; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (654 aa)
BCL2BCL2 apoptosis regulator. (237 aa)
TFF2Trefoil factor 2. (176 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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