8 items (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SFTPD	Surfactant protein D. (458 aa)
	ACE2	Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...] (805 aa)
	MME	Membrane metalloendopeptidase. (749 aa)
	NTS	Neurotensin. (173 aa)
	MMEL1	Membrane metalloendopeptidase like 1. (818 aa)
	TMPRSS2	Transmembrane serine protease 2; Belongs to the peptidase S1 family. (492 aa)
	ADAM17	ADAM metallopeptidase domain 17. (828 aa)
	REN	Renin; Belongs to the peptidase A1 family. (404 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE2	ADAM17	ENSFCAP00000052000	ENSFCAP00000007272	Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...]	ADAM metallopeptidase domain 17.	0.800
ACE2	MME	ENSFCAP00000052000	ENSFCAP00000051149	Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...]	Membrane metalloendopeptidase.	0.961
ACE2	MMEL1	ENSFCAP00000052000	ENSFCAP00000008831	Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...]	Membrane metalloendopeptidase like 1.	0.509
ACE2	REN	ENSFCAP00000052000	ENSFCAP00000002671	Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...]	Renin; Belongs to the peptidase A1 family.	0.860
ACE2	TMPRSS2	ENSFCAP00000052000	ENSFCAP00000007479	Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...]	Transmembrane serine protease 2; Belongs to the peptidase S1 family.	0.947
ADAM17	ACE2	ENSFCAP00000007272	ENSFCAP00000052000	ADAM metallopeptidase domain 17.	Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...]	0.800
ADAM17	REN	ENSFCAP00000007272	ENSFCAP00000002671	ADAM metallopeptidase domain 17.	Renin; Belongs to the peptidase A1 family.	0.493
ADAM17	TMPRSS2	ENSFCAP00000007272	ENSFCAP00000007479	ADAM metallopeptidase domain 17.	Transmembrane serine protease 2; Belongs to the peptidase S1 family.	0.716
MME	ACE2	ENSFCAP00000051149	ENSFCAP00000052000	Membrane metalloendopeptidase.	Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...]	0.961
MME	REN	ENSFCAP00000051149	ENSFCAP00000002671	Membrane metalloendopeptidase.	Renin; Belongs to the peptidase A1 family.	0.620
MMEL1	ACE2	ENSFCAP00000008831	ENSFCAP00000052000	Membrane metalloendopeptidase like 1.	Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...]	0.509
MMEL1	REN	ENSFCAP00000008831	ENSFCAP00000002671	Membrane metalloendopeptidase like 1.	Renin; Belongs to the peptidase A1 family.	0.575
REN	ACE2	ENSFCAP00000002671	ENSFCAP00000052000	Renin; Belongs to the peptidase A1 family.	Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...]	0.860
REN	ADAM17	ENSFCAP00000002671	ENSFCAP00000007272	Renin; Belongs to the peptidase A1 family.	ADAM metallopeptidase domain 17.	0.493
REN	MME	ENSFCAP00000002671	ENSFCAP00000051149	Renin; Belongs to the peptidase A1 family.	Membrane metalloendopeptidase.	0.620
REN	MMEL1	ENSFCAP00000002671	ENSFCAP00000008831	Renin; Belongs to the peptidase A1 family.	Membrane metalloendopeptidase like 1.	0.575
REN	TMPRSS2	ENSFCAP00000002671	ENSFCAP00000007479	Renin; Belongs to the peptidase A1 family.	Transmembrane serine protease 2; Belongs to the peptidase S1 family.	0.652
TMPRSS2	ACE2	ENSFCAP00000007479	ENSFCAP00000052000	Transmembrane serine protease 2; Belongs to the peptidase S1 family.	Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...]	0.947
TMPRSS2	ADAM17	ENSFCAP00000007479	ENSFCAP00000007272	Transmembrane serine protease 2; Belongs to the peptidase S1 family.	ADAM metallopeptidase domain 17.	0.716
TMPRSS2	REN	ENSFCAP00000007479	ENSFCAP00000002671	Transmembrane serine protease 2; Belongs to the peptidase S1 family.	Renin; Belongs to the peptidase A1 family.	0.652