47 items (Felis catus) - STRING interaction network

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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gene fusions

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Your Input:
	TDO2	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (406 aa)
	CXCL10	C-X-C motif chemokine. (98 aa)
	DNMT1	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1710 aa)
	SLC25A44	Solute carrier family 25 member 44; Belongs to the mitochondrial carrier (TC 2.A.29) family. (314 aa)
	CXCL9	C-X-C motif chemokine. (155 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
	TLR2	Toll like receptor 2; Belongs to the Toll-like receptor family. (784 aa)
	FABP4	Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	CDO1	Cysteine dioxygenase. (200 aa)
	SRM	Spermidine synthase; Belongs to the spermidine/spermine synthase family. (302 aa)
	EDN1	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (201 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	LDLR	Low density lipoprotein receptor. (866 aa)
	BCAT1	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (457 aa)
	CSAD	Cysteine sulfinic acid decarboxylase. (540 aa)
	IVD	Isovaleryl-CoA dehydrogenase. (700 aa)
	ARG1	Arginase. (329 aa)
	CBS	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (633 aa)
	IDO2	Indoleamine 2,3-dioxygenase 2. (410 aa)
	ODC1	Ornithine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (503 aa)
	TLR4	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa)
	APOB	Apolipoprotein B. (4441 aa)
	SOD2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
	HIBADH	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (336 aa)
	LOC101101148	Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (457 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa)
	BHMT	Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. (407 aa)
	IL10	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
	CTH	Cystathionine gamma-lyase. (405 aa)
	AGMAT	Agmatinase; Belongs to the arginase family. (352 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
	ASL	Uncharacterized protein. (477 aa)
	NAXE	NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (301 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	MTR	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1214 aa)
	IDO1	Indoleamine 2,3-dioxygenase 1. (407 aa)
	SMS	Spermine synthase. (476 aa)
	ARG2	Arginase. (354 aa)
	OAT	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (439 aa)
	SLC7A1	Solute carrier family 7 member 1. (803 aa)
	MMUT	Methylmalonyl-CoA mutase. (769 aa)
	ALB	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (618 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (917 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	CXCL11	C-X-C motif chemokine. (100 aa)
	TLR9	Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1031 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGMAT	ARG1	ENSFCAP00000010752	ENSFCAP00000056022	Agmatinase; Belongs to the arginase family.	Arginase.	0.470
AGMAT	ARG2	ENSFCAP00000010752	ENSFCAP00000013066	Agmatinase; Belongs to the arginase family.	Arginase.	0.469
AGMAT	ASL	ENSFCAP00000010752	ENSFCAP00000006432	Agmatinase; Belongs to the arginase family.	Uncharacterized protein.	0.847
AGMAT	BHMT	ENSFCAP00000010752	ENSFCAP00000024440	Agmatinase; Belongs to the arginase family.	Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism.	0.437
AGMAT	CTH	ENSFCAP00000010752	ENSFCAP00000011548	Agmatinase; Belongs to the arginase family.	Cystathionine gamma-lyase.	0.484
AGMAT	LOC101101148	ENSFCAP00000010752	ENSFCAP00000022846	Agmatinase; Belongs to the arginase family.	Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	0.973
AGMAT	MTR	ENSFCAP00000010752	ENSFCAP00000004108	Agmatinase; Belongs to the arginase family.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.419
AGMAT	OAT	ENSFCAP00000010752	ENSFCAP00000012841	Agmatinase; Belongs to the arginase family.	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.929
AGMAT	ODC1	ENSFCAP00000010752	ENSFCAP00000061170	Agmatinase; Belongs to the arginase family.	Ornithine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	0.977
AGMAT	SLC7A1	ENSFCAP00000010752	ENSFCAP00000013290	Agmatinase; Belongs to the arginase family.	Solute carrier family 7 member 1.	0.586
AGMAT	SMS	ENSFCAP00000010752	ENSFCAP00000002241	Agmatinase; Belongs to the arginase family.	Spermine synthase.	0.888
AGMAT	SRM	ENSFCAP00000010752	ENSFCAP00000014521	Agmatinase; Belongs to the arginase family.	Spermidine synthase; Belongs to the spermidine/spermine synthase family.	0.988
ALB	APOB	ENSFCAP00000028536	ENSFCAP00000023369	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Apolipoprotein B.	0.782
ALB	ARG1	ENSFCAP00000028536	ENSFCAP00000056022	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Arginase.	0.554
ALB	ARG2	ENSFCAP00000028536	ENSFCAP00000013066	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Arginase.	0.465
ALB	CBS	ENSFCAP00000028536	ENSFCAP00000059302	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.	0.621
ALB	CXCL10	ENSFCAP00000028536	ENSFCAP00000043600	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	C-X-C motif chemokine.	0.536
ALB	CXCL9	ENSFCAP00000028536	ENSFCAP00000046981	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	C-X-C motif chemokine.	0.414
ALB	DNMT1	ENSFCAP00000028536	ENSFCAP00000044002	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.437
ALB	EDN1	ENSFCAP00000028536	ENSFCAP00000013767	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	0.568