STRINGSTRING
SKP1 SKP1 EGF EGF TBK1 TBK1 RELA RELA TRAF6 TRAF6 CGAS CGAS EGFR EGFR PLD1 PLD1 TANK TANK IL7 IL7 IL18BP IL18BP IL18 IL18 RELB RELB ATF3 ATF3 CUL1 CUL1 IL6 IL6 IRAK2 IRAK2 IL1A IL1A PLD2 PLD2 IRF3 IRF3 IL1B IL1B IFI16 IFI16 BCL2 BCL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SKP1Uncharacterized protein; Belongs to the SKP1 family. (168 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1213 aa)
TBK1TANK binding kinase 1. (729 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
CGASCyclic GMP-AMP synthase. (514 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
PLD1Phospholipase. (1074 aa)
TANKTRAF family member associated NFKB activator. (445 aa)
IL7Interleukin 7. (158 aa)
IL18BPInterleukin 18 binding protein. (183 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa)
RELBRELB proto-oncogene, NF-kB subunit. (582 aa)
ATF3Activating transcription factor 3. (259 aa)
CUL1Cullin 1; Belongs to the cullin family. (829 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (618 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa)
PLD2Phospholipase. (984 aa)
IRF3Interferon regulatory factor 3. (420 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
IFI16Uncharacterized protein. (684 aa)
BCL2BCL2 apoptosis regulator. (237 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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