37 items (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	PFN4	Profilin; Belongs to the profilin family. (129 aa)
	TNP2	Nuclear transition protein 2; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. (119 aa)
	LMNB1	Lamin B1; Belongs to the intermediate filament family. (586 aa)
	PICK1	Protein interacting with PRKCA 1. (417 aa)
	RNF19A	RBR-type E3 ubiquitin transferase. (838 aa)
	IFT88	Intraflagellar transport 88. (831 aa)
	PGR	Progesterone receptor. (932 aa)
	PSMC3	Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (439 aa)
	LDHC	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (358 aa)
	TNP1	Transition protein 1. (55 aa)
	ALB	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (618 aa)
	SUN3	Sad1 and UNC84 domain containing 3. (353 aa)
	CDC42-2	Uncharacterized protein. (191 aa)
	SUN5	Sad1 and UNC84 domain containing 5. (365 aa)
	TSGA10	Testis specific 10. (697 aa)
	RANBP17	RAN binding protein 17. (1215 aa)
	CEP112	Centrosomal protein 112. (955 aa)
	SPEM1	Spermatid maturation 1. (300 aa)
	DPY19L2	Dpy-19 like 2. (799 aa)
	BRDT	Bromodomain testis associated. (876 aa)
	SUN2	Sad1 and UNC84 domain containing 2. (749 aa)
	CTTN	Cortactin. (538 aa)
	HCLS1	Hematopoietic cell-specific Lyn substrate 1. (494 aa)
	ADCY10	Adenylate cyclase 10. (1608 aa)
	LMNA	Lamin A/C; Belongs to the intermediate filament family. (664 aa)
	SPATA16	Spermatogenesis associated 16. (570 aa)
	H1-6	Histone cluster 1 H1 family member t. (211 aa)
	PMFBP1	Polyamine modulated factor 1 binding protein 1. (1009 aa)
	SPAG6	Sperm associated antigen 6. (509 aa)
	SUN1	Sad1 and UNC84 domain containing 1. (940 aa)
	CDC42	Uncharacterized protein. (191 aa)
	DNAH6	Dynein axonemal heavy chain 6. (4155 aa)
	MYO5A	Myosin VA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1855 aa)
	LMNB2	Lamin B2; Belongs to the intermediate filament family. (718 aa)
	SYNE1	Spectrin repeat containing nuclear envelope protein 1. (8795 aa)
	CCDC42	Coiled-coil domain containing 42. (389 aa)
	AFDN	Afadin, adherens junction formation factor. (1873 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALB	CDC42	ENSFCAP00000028536	ENSFCAP00000004483	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Uncharacterized protein.	0.455
ALB	CDC42-2	ENSFCAP00000028536	ENSFCAP00000024478	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Uncharacterized protein.	0.455
ALB	CTTN	ENSFCAP00000028536	ENSFCAP00000004407	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Cortactin.	0.455
ALB	HCLS1	ENSFCAP00000028536	ENSFCAP00000014396	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Hematopoietic cell-specific Lyn substrate 1.	0.455
ALB	LMNA	ENSFCAP00000028536	ENSFCAP00000010931	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Lamin A/C; Belongs to the intermediate filament family.	0.534
ALB	LMNB1	ENSFCAP00000028536	ENSFCAP00000002897	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Lamin B1; Belongs to the intermediate filament family.	0.611
ALB	LMNB2	ENSFCAP00000028536	ENSFCAP00000052716	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Lamin B2; Belongs to the intermediate filament family.	0.519
ALB	PFN4	ENSFCAP00000028536	ENSFCAP00000003972	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Profilin; Belongs to the profilin family.	0.426
ALB	PGR	ENSFCAP00000028536	ENSFCAP00000049487	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Progesterone receptor.	0.536
BRDT	PMFBP1	ENSFCAP00000017154	ENSFCAP00000005416	Bromodomain testis associated.	Polyamine modulated factor 1 binding protein 1.	0.573
BRDT	SUN5	ENSFCAP00000017154	ENSFCAP00000023359	Bromodomain testis associated.	Sad1 and UNC84 domain containing 5.	0.511
BRDT	TNP1	ENSFCAP00000017154	ENSFCAP00000036070	Bromodomain testis associated.	Transition protein 1.	0.455
BRDT	TSGA10	ENSFCAP00000017154	ENSFCAP00000021894	Bromodomain testis associated.	Testis specific 10.	0.455
CCDC42	IFT88	ENSFCAP00000053755	ENSFCAP00000000793	Coiled-coil domain containing 42.	Intraflagellar transport 88.	0.450
CCDC42	SUN3	ENSFCAP00000053755	ENSFCAP00000026759	Coiled-coil domain containing 42.	Sad1 and UNC84 domain containing 3.	0.437
CCDC42	SUN5	ENSFCAP00000053755	ENSFCAP00000023359	Coiled-coil domain containing 42.	Sad1 and UNC84 domain containing 5.	0.497
CDC42	ALB	ENSFCAP00000004483	ENSFCAP00000028536	Uncharacterized protein.	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	0.455
CDC42	CTTN	ENSFCAP00000004483	ENSFCAP00000004407	Uncharacterized protein.	Cortactin.	0.628
CDC42	HCLS1	ENSFCAP00000004483	ENSFCAP00000014396	Uncharacterized protein.	Hematopoietic cell-specific Lyn substrate 1.	0.613
CDC42	PFN4	ENSFCAP00000004483	ENSFCAP00000003972	Uncharacterized protein.	Profilin; Belongs to the profilin family.	0.560