STRINGSTRING
PXN PXN EFNA5 EFNA5 RABIF RABIF SRC SRC CANX CANX SLIT2 SLIT2 TNS1 TNS1 PXDN PXDN ROCK1 ROCK1 EFNB3 EFNB3 EFNA2 EFNA2 EFNA3 EFNA3 TNS3 TNS3 EGF EGF EFNB1 EFNB1 EFNA4 EFNA4 TNS2 TNS2 PXDNL PXDNL GAPDH GAPDH HDAC3 HDAC3 EPHA4 EPHA4 RPL13A RPL13A TNS4 TNS4 EPHA2 EPHA2 VAV2 VAV2 EFNB2 EFNB2 RHOA RHOA TOMM20 TOMM20 FERMT2 FERMT2 VCL VCL ALB ALB EPHB2 EPHB2 TFRC TFRC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PXNPaxillin. (1089 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
RABIFRAB interacting factor. (123 aa)
SRCTyrosine-protein kinase. (678 aa)
CANXCalnexin. (637 aa)
SLIT2Slit guidance ligand 2. (1543 aa)
TNS1Tensin 1. (1901 aa)
PXDNPeroxidasin. (1502 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa)
EFNB3Ephrin RBD domain-containing protein; Belongs to the ephrin family. (340 aa)
EFNA2Ephrin A2; Belongs to the ephrin family. (263 aa)
EFNA3Ephrin RBD domain-containing protein; Belongs to the ephrin family. (237 aa)
TNS3Tensin 3. (1553 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1213 aa)
EFNB1Ephrin B1. (427 aa)
EFNA4Ephrin RBD domain-containing protein; Belongs to the ephrin family. (314 aa)
TNS2Tensin 2. (1409 aa)
PXDNLPeroxidasin like. (1457 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
EPHA4EPH receptor A4. (986 aa)
RPL13ARibosomal protein L13a; Belongs to the universal ribosomal protein uL13 family. (203 aa)
TNS4Tensin 4. (715 aa)
EPHA2EPH receptor A2. (936 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (333 aa)
RHOARas homolog family member A. (193 aa)
TOMM20Translocase of outer mitochondrial membrane 20. (145 aa)
FERMT2Fermitin family member 2. (706 aa)
VCLVinculin. (1066 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (618 aa)
EPHB2EPH receptor B2. (899 aa)
TFRCTransferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity); Belongs to the [...] (789 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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