STRINGSTRING
EFNB3 EFNB3 PARN PARN PRKN PRKN IGF1 IGF1 IL1F10 IL1F10 ACE ACE PLAT PLAT CDK2 CDK2 FOXO4 FOXO4 SIRT1 SIRT1 IL36RN IL36RN IL6 IL6 GLO1 GLO1 GLB1 GLB1 CHEK1 CHEK1 EDN1 EDN1 KL KL BECN1 BECN1 EPO EPO CD4 CD4 REN REN PNLDC1 PNLDC1 STAT3 STAT3 PINK1 PINK1 MTOR MTOR BCL2 BCL2 EFNB1 EFNB1 LOC101083124 LOC101083124 IL36G IL36G GLB1L2 GLB1L2 PPARG PPARG IL1RN IL1RN CDK6 CDK6 FGF23 FGF23 LOC101098007 LOC101098007
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EFNB3Ephrin RBD domain-containing protein; Belongs to the ephrin family. (340 aa)
PARNPoly(A)-specific ribonuclease. (638 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (462 aa)
IGF1Insulin like growth factor 1. (195 aa)
IL1F10Interleukin-1. (152 aa)
ACEAngiotensin-converting enzyme. (1307 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (563 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
FOXO4Forkhead box O4. (515 aa)
SIRT1Sirtuin 1. (745 aa)
IL36RNInterleukin-1. (196 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa)
GLO1Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (184 aa)
GLB1Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Belongs to the glycosyl hydrolase 35 family. (669 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (201 aa)
KLKlotho. (1014 aa)
BECN1Beclin 1. (448 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. (192 aa)
CD4CD4 molecule. (487 aa)
RENRenin; Belongs to the peptidase A1 family. (404 aa)
PNLDC1PARN like, ribonuclease domain containing 1. (531 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PINK1PTEN induced kinase 1. (581 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa)
BCL2BCL2 apoptosis regulator. (237 aa)
EFNB1Ephrin B1. (427 aa)
LOC101083124Angiotensin-converting enzyme. (714 aa)
IL36GInterleukin-1. (219 aa)
GLB1L2Beta-galactosidase. (697 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
IL1RNInterleukin-1. (182 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (338 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
LOC101098007Beta-galactosidase. (722 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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