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CMAH CMAH COMT COMT GGTA1 GGTA1 VWF VWF EGFR EGFR FUT1 FUT1 CFTR CFTR ALB ALB VKORC1 VKORC1 EGR1 EGR1 MTHFR MTHFR ALDH2 ALDH2 GLB1 GLB1 FUT2 FUT2 ALDH3B1 ALDH3B1 MCM6 MCM6 PIGG PIGG RUNX1 RUNX1 CASP12 CASP12 ALDH3A1 ALDH3A1 KLF1 KLF1 CD55 CD55 FUCA1 FUCA1 ALDH3A2 ALDH3A2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CMAHRieske domain-containing protein. (649 aa)
COMTCatechol-O-methyltransferase. (303 aa)
GGTA1N-acetyllactosaminide alpha-1,3-galactosyltransferase; Synthesizes the galactose-alpha(1,3)-galactose group by catalyzing the transfer of a galactose residue, with an alpha-1,3 linkage, on terminal lactosaminide (Gal-beta-1,4-GlcNAc-R) disaccharide borne by a glycoprotein or a glycolipid. Preferentially glycosylates proteins, can synthesize galactose-alpha(1,3)-galactose on glycoproteins but cannot synthesize the glycolipid called isogloboside 3 (iGb3) (By similarity); Belongs to the glycosyltransferase 6 family. (676 aa)
VWFUncharacterized protein. (2818 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
FUT1L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (491 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1481 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (618 aa)
VKORC1Vitamin K epoxide reductase complex subunit 1. (206 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (543 aa)
MTHFRMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (695 aa)
ALDH2Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (517 aa)
GLB1Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Belongs to the glycosyl hydrolase 35 family. (669 aa)
FUT2L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (331 aa)
ALDH3B1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (489 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
PIGGPhosphatidylinositol glycan anchor biosynthesis class G. (983 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (493 aa)
CASP12Uncharacterized protein; Belongs to the peptidase C14A family. (527 aa)
ALDH3A1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (478 aa)
KLF1Kruppel like factor 1. (362 aa)
CD55Uncharacterized protein. (464 aa)
FUCA1Alpha-L-fucosidase 1. (721 aa)
ALDH3A2Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (515 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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