(18 nodes) (2023) Host-Pathogen Interactions Influencing Zoonotic Spillover Potential and Transmission in Humans. network (Felis catus)

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second shell of interactors

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Predicted Interactions

gene neighborhood

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Your Input:
	LOC101100838	Uncharacterized protein. (124 aa)
	IFIH1	Interferon induced with helicase C domain 1. (1026 aa)
	PLK1	Serine/threonine-protein kinase PLK. (604 aa)
	EFNB2	Ephrin B2; Belongs to the ephrin family. (333 aa)
	CCR5	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (352 aa)
	ACE2	Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...] (805 aa)
	STAT1	Signal transducer and activator of transcription. (885 aa)
	NPC1	NPC intracellular cholesterol transporter 1. (1276 aa)
	CD55	Uncharacterized protein. (464 aa)
	MX1	MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (675 aa)
	CD4	CD4 molecule. (487 aa)
	IFNB1	Interferon beta; Has antiviral, antibacterial and anticancer activities. (186 aa)
	IRF3	Interferon regulatory factor 3. (420 aa)
	STAT2	Signal transducer and activator of transcription. (855 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (917 aa)
	SFTPD	Surfactant protein D. (458 aa)
	TLR4	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa)
	VDR	Vitamin D receptor. (441 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE2	CD4	ENSFCAP00000052000	ENSFCAP00000003936	Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...]	CD4 molecule.	0.660
ACE2	IFNB1	ENSFCAP00000052000	ENSFCAP00000004253	Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...]	Interferon beta; Has antiviral, antibacterial and anticancer activities.	0.447
ACE2	TLR3	ENSFCAP00000052000	ENSFCAP00000028836	Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...]	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.405
CCR5	CD4	ENSFCAP00000054547	ENSFCAP00000003936	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	CD4 molecule.	0.990
CCR5	STAT1	ENSFCAP00000054547	ENSFCAP00000050611	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Signal transducer and activator of transcription.	0.568
CCR5	TLR3	ENSFCAP00000054547	ENSFCAP00000028836	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.431
CCR5	TLR4	ENSFCAP00000054547	ENSFCAP00000023731	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.621
CD4	ACE2	ENSFCAP00000003936	ENSFCAP00000052000	CD4 molecule.	Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...]	0.660
CD4	CCR5	ENSFCAP00000003936	ENSFCAP00000054547	CD4 molecule.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.990
CD4	CD55	ENSFCAP00000003936	ENSFCAP00000061491	CD4 molecule.	Uncharacterized protein.	0.428
CD4	IFNB1	ENSFCAP00000003936	ENSFCAP00000004253	CD4 molecule.	Interferon beta; Has antiviral, antibacterial and anticancer activities.	0.582
CD4	IRF3	ENSFCAP00000003936	ENSFCAP00000005645	CD4 molecule.	Interferon regulatory factor 3.	0.565
CD4	MX1	ENSFCAP00000003936	ENSFCAP00000058609	CD4 molecule.	MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.446
CD4	STAT1	ENSFCAP00000003936	ENSFCAP00000050611	CD4 molecule.	Signal transducer and activator of transcription.	0.718
CD4	STAT2	ENSFCAP00000003936	ENSFCAP00000011155	CD4 molecule.	Signal transducer and activator of transcription.	0.489
CD4	TLR3	ENSFCAP00000003936	ENSFCAP00000028836	CD4 molecule.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.718
CD4	TLR4	ENSFCAP00000003936	ENSFCAP00000023731	CD4 molecule.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.793
CD55	CD4	ENSFCAP00000061491	ENSFCAP00000003936	Uncharacterized protein.	CD4 molecule.	0.428
IFIH1	IFNB1	ENSFCAP00000019326	ENSFCAP00000004253	Interferon induced with helicase C domain 1.	Interferon beta; Has antiviral, antibacterial and anticancer activities.	0.742
IFIH1	IRF3	ENSFCAP00000019326	ENSFCAP00000005645	Interferon induced with helicase C domain 1.	Interferon regulatory factor 3.	0.874