(14 nodes) (2023) The role of lysosomes as intermediates in betacoronavirus PHEV egress from nerve cells. network (Felis catus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GAPDHS	Glyceraldehyde-3-phosphate dehydrogenase. (405 aa)
	ARL8B	ADP ribosylation factor like GTPase 8B; Belongs to the small GTPase superfamily. Arf family. (186 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
	CTSD	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (408 aa)
	ATP6V1D	ATPase H+ transporting V1 subunit D. (247 aa)
	ATP6AP1	ATPase H+ transporting accessory protein 1. (465 aa)
	ATP6V1B1	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
	LAMP1	Lysosomal associated membrane protein 1. (422 aa)
	ATP6V1A	ATPase H+ transporting V1 subunit A. (618 aa)
	MAP1A	Microtubule associated protein 1A. (2991 aa)
	ATP6V0A1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (863 aa)
	ATP6V1B2	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (528 aa)
	CTSB	Cathepsin B; Belongs to the peptidase C1 family. (339 aa)
	ACE2	Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...] (805 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE2	CTSB	ENSFCAP00000052000	ENSFCAP00000051086	Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...]	Cathepsin B; Belongs to the peptidase C1 family.	0.527
ARL8B	LAMP1	ENSFCAP00000000682	ENSFCAP00000013220	ADP ribosylation factor like GTPase 8B; Belongs to the small GTPase superfamily. Arf family.	Lysosomal associated membrane protein 1.	0.405
ATP6AP1	ATP6V0A1	ENSFCAP00000010590	ENSFCAP00000038798	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.999
ATP6AP1	ATP6V1A	ENSFCAP00000010590	ENSFCAP00000022347	ATPase H+ transporting accessory protein 1.	ATPase H+ transporting V1 subunit A.	0.997
ATP6AP1	ATP6V1B1	ENSFCAP00000010590	ENSFCAP00000012478	ATPase H+ transporting accessory protein 1.	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	0.990
ATP6AP1	ATP6V1B2	ENSFCAP00000010590	ENSFCAP00000039821	ATPase H+ transporting accessory protein 1.	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	0.992
ATP6AP1	ATP6V1D	ENSFCAP00000010590	ENSFCAP00000010292	ATPase H+ transporting accessory protein 1.	ATPase H+ transporting V1 subunit D.	0.998
ATP6V0A1	ATP6AP1	ENSFCAP00000038798	ENSFCAP00000010590	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	ATPase H+ transporting accessory protein 1.	0.999
ATP6V0A1	ATP6V1A	ENSFCAP00000038798	ENSFCAP00000022347	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	ATPase H+ transporting V1 subunit A.	0.998
ATP6V0A1	ATP6V1B1	ENSFCAP00000038798	ENSFCAP00000012478	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	0.988
ATP6V0A1	ATP6V1B2	ENSFCAP00000038798	ENSFCAP00000039821	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	0.991
ATP6V0A1	ATP6V1D	ENSFCAP00000038798	ENSFCAP00000010292	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	ATPase H+ transporting V1 subunit D.	0.998
ATP6V1A	ATP6AP1	ENSFCAP00000022347	ENSFCAP00000010590	ATPase H+ transporting V1 subunit A.	ATPase H+ transporting accessory protein 1.	0.997
ATP6V1A	ATP6V0A1	ENSFCAP00000022347	ENSFCAP00000038798	ATPase H+ transporting V1 subunit A.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.998
ATP6V1A	ATP6V1B1	ENSFCAP00000022347	ENSFCAP00000012478	ATPase H+ transporting V1 subunit A.	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	0.994
ATP6V1A	ATP6V1B2	ENSFCAP00000022347	ENSFCAP00000039821	ATPase H+ transporting V1 subunit A.	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	0.999
ATP6V1A	ATP6V1D	ENSFCAP00000022347	ENSFCAP00000010292	ATPase H+ transporting V1 subunit A.	ATPase H+ transporting V1 subunit D.	0.999
ATP6V1A	LAMP1	ENSFCAP00000022347	ENSFCAP00000013220	ATPase H+ transporting V1 subunit A.	Lysosomal associated membrane protein 1.	0.458
ATP6V1B1	ATP6AP1	ENSFCAP00000012478	ENSFCAP00000010590	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	ATPase H+ transporting accessory protein 1.	0.990
ATP6V1B1	ATP6V0A1	ENSFCAP00000012478	ENSFCAP00000038798	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.988