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IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa) | ||||
ASS1 | Argininosuccinate synthase 1. (412 aa) | ||||
SLC1A1 | Amino acid transporter. (486 aa) | ||||
PSPH | Phosphoserine phosphatase. (276 aa) | ||||
SLC38A2 | Solute carrier family 38 member 2. (506 aa) | ||||
KRAS | Uncharacterized protein. (380 aa) | ||||
SRM | Spermidine synthase; Belongs to the spermidine/spermine synthase family. (302 aa) | ||||
SHMT1 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (484 aa) | ||||
SLC3A2 | Solute carrier family 3 member 2. (170 aa) | ||||
ARG2 | Arginase. (354 aa) | ||||
METTL3 | Methyltransferase like 3; Belongs to the MT-A70-like family. (558 aa) | ||||
PRMT7 | Protein arginine N-methyltransferase; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being r [...] (694 aa) | ||||
CHAC1 | Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (222 aa) | ||||
RHEB | Ras homolog, mTORC1 binding. (187 aa) | ||||
SLC7A5 | Solute carrier family 7 member 5. (509 aa) | ||||
GLS2 | Glutaminase 2. (602 aa) | ||||
CASTOR1 | Cytosolic arginine sensor for mTORC1 subunit 1. (329 aa) | ||||
DEPTOR | DEP domain containing MTOR interacting protein. (411 aa) | ||||
CSF1 | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (569 aa) | ||||
GNMT | Glycine N-methyltransferase. (295 aa) | ||||
TYMS | Thymidylate synthetase. (316 aa) | ||||
LARS1 | Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (1176 aa) | ||||
MTHFD2 | Uncharacterized protein. (350 aa) | ||||
SLC1A6 | Amino acid transporter. (564 aa) | ||||
BCAT2 | Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (404 aa) | ||||
AR | Androgen receptor. (903 aa) | ||||
ASL | Uncharacterized protein. (477 aa) | ||||
KLHL22 | Kelch like family member 22. (634 aa) | ||||
IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa) | ||||
SLC1A5 | Amino acid transporter. (541 aa) | ||||
SLC1A3 | Amino acid transporter. (542 aa) | ||||
AHR | Uncharacterized protein. (849 aa) | ||||
EP300 | E1A binding protein p300. (2425 aa) | ||||
SPTLC1 | Serine palmitoyltransferase long chain base subunit 1. (473 aa) | ||||
RNF5 | Ring finger protein 5. (180 aa) | ||||
CD4 | CD4 molecule. (487 aa) | ||||
IDH1 | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa) | ||||
RRM2 | Ribonucleotide reductase regulatory subunit M2. (393 aa) | ||||
IDO1 | Indoleamine 2,3-dioxygenase 1. (407 aa) | ||||
SMS | Spermine synthase. (476 aa) | ||||
HDAC5 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1152 aa) | ||||
GLDC | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1019 aa) | ||||
SAR1B | Secretion associated Ras related GTPase 1B; Belongs to the small GTPase superfamily. SAR1 family. (198 aa) | ||||
MMP13 | Matrix metallopeptidase 13. (470 aa) | ||||
NOS2 | Nitric oxide synthase; Produces nitric oxide (NO). (1165 aa) | ||||
HDAC4 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1083 aa) | ||||
HDAC9 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1068 aa) | ||||
SPTLC3 | Serine palmitoyltransferase long chain base subunit 3. (552 aa) | ||||
ALB | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (618 aa) | ||||
MLST8 | MTOR associated protein, LST8 homolog. (326 aa) | ||||
SLC38A9 | Solute carrier family 38 member 9. (561 aa) | ||||
SLC6A14 | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (639 aa) | ||||
KMO | Kynurenine 3-monooxygenase. (453 aa) | ||||
GOT2 | Aspartate aminotransferase. (430 aa) | ||||
AFMID | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (306 aa) | ||||
GPT | Glutamic--pyruvic transaminase. (496 aa) | ||||
ASNS | Asparagine synthetase [glutamine-hydrolyzing]. (561 aa) | ||||
SLC38A5 | Solute carrier family 38 member 5. (557 aa) | ||||
SHMT2 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (542 aa) | ||||
SPTLC2 | Serine palmitoyltransferase long chain base subunit 2. (694 aa) | ||||
EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1213 aa) | ||||
DHFR | DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (212 aa) | ||||
SLC1A7 | Amino acid transporter. (624 aa) | ||||
PHGDH | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (586 aa) | ||||
LARS2 | Leucyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (862 aa) | ||||
SIRT3 | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (417 aa) | ||||
ARG1 | Arginase. (329 aa) | ||||
SESN2 | Sestrin 2. (516 aa) | ||||
KYNU | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (469 aa) | ||||
SIRT4 | Sirtuin 4. (335 aa) | ||||
SLC1A2 | Amino acid transporter. (579 aa) | ||||
BCAT1 | Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (457 aa) | ||||
RICTOR | RPTOR independent companion of MTOR complex 2. (1732 aa) | ||||
GLUL | Glutamine synthetase. (506 aa) | ||||
PCK2 | Phosphoenolpyruvate carboxykinase 2, mitochondrial. (620 aa) | ||||
HDAC7 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1070 aa) | ||||
SLC43A1 | Solute carrier family 43 member 1. (687 aa) | ||||
CGAS | Cyclic GMP-AMP synthase. (514 aa) | ||||
BCKDK | Protein-serine/threonine kinase. (412 aa) | ||||
TDO2 | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (406 aa) | ||||
IGF1 | Insulin like growth factor 1. (195 aa) | ||||
EGFR | Receptor protein-tyrosine kinase. (1209 aa) | ||||
BMT2 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa) | ||||
TFEB | Transcription factor EB. (478 aa) | ||||
LCK | Tyrosine-protein kinase. (520 aa) | ||||
ASPG | Asparaginase. (571 aa) | ||||
SLC43A2 | Solute carrier family 43 member 2. (572 aa) | ||||
IDH2 | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (451 aa) |