STRINGSTRING
IL6 IL6 ASS1 ASS1 SLC1A1 SLC1A1 PSPH PSPH SLC38A2 SLC38A2 KRAS KRAS SRM SRM SHMT1 SHMT1 SLC3A2 SLC3A2 ARG2 ARG2 METTL3 METTL3 PRMT7 PRMT7 CHAC1 CHAC1 RHEB RHEB SLC7A5 SLC7A5 GLS2 GLS2 CASTOR1 CASTOR1 DEPTOR DEPTOR CSF1 CSF1 GNMT GNMT TYMS TYMS LARS1 LARS1 MTHFD2 MTHFD2 SLC1A6 SLC1A6 BCAT2 BCAT2 AR AR ASL ASL KLHL22 KLHL22 IL1B IL1B SLC1A5 SLC1A5 SLC1A3 SLC1A3 AHR AHR EP300 EP300 SPTLC1 SPTLC1 RNF5 RNF5 CD4 CD4 IDH1 IDH1 RRM2 RRM2 IDO1 IDO1 SMS SMS HDAC5 HDAC5 GLDC GLDC SAR1B SAR1B MMP13 MMP13 NOS2 NOS2 HDAC4 HDAC4 HDAC9 HDAC9 SPTLC3 SPTLC3 ALB ALB MLST8 MLST8 SLC38A9 SLC38A9 SLC6A14 SLC6A14 KMO KMO GOT2 GOT2 AFMID AFMID GPT GPT ASNS ASNS SLC38A5 SLC38A5 SHMT2 SHMT2 SPTLC2 SPTLC2 EGF EGF DHFR DHFR SLC1A7 SLC1A7 PHGDH PHGDH LARS2 LARS2 SIRT3 SIRT3 ARG1 ARG1 SESN2 SESN2 KYNU KYNU SIRT4 SIRT4 SLC1A2 SLC1A2 BCAT1 BCAT1 RICTOR RICTOR GLUL GLUL PCK2 PCK2 HDAC7 HDAC7 SLC43A1 SLC43A1 CGAS CGAS BCKDK BCKDK TDO2 TDO2 IGF1 IGF1 EGFR EGFR BMT2 BMT2 TFEB TFEB LCK LCK ASPG ASPG SLC43A2 SLC43A2 IDH2 IDH2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa)
ASS1Argininosuccinate synthase 1. (412 aa)
SLC1A1Amino acid transporter. (486 aa)
PSPHPhosphoserine phosphatase. (276 aa)
SLC38A2Solute carrier family 38 member 2. (506 aa)
KRASUncharacterized protein. (380 aa)
SRMSpermidine synthase; Belongs to the spermidine/spermine synthase family. (302 aa)
SHMT1Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (484 aa)
SLC3A2Solute carrier family 3 member 2. (170 aa)
ARG2Arginase. (354 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (558 aa)
PRMT7Protein arginine N-methyltransferase; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being r [...] (694 aa)
CHAC1Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (222 aa)
RHEBRas homolog, mTORC1 binding. (187 aa)
SLC7A5Solute carrier family 7 member 5. (509 aa)
GLS2Glutaminase 2. (602 aa)
CASTOR1Cytosolic arginine sensor for mTORC1 subunit 1. (329 aa)
DEPTORDEP domain containing MTOR interacting protein. (411 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (569 aa)
GNMTGlycine N-methyltransferase. (295 aa)
TYMSThymidylate synthetase. (316 aa)
LARS1Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (1176 aa)
MTHFD2Uncharacterized protein. (350 aa)
SLC1A6Amino acid transporter. (564 aa)
BCAT2Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (404 aa)
ARAndrogen receptor. (903 aa)
ASLUncharacterized protein. (477 aa)
KLHL22Kelch like family member 22. (634 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
SLC1A5Amino acid transporter. (541 aa)
SLC1A3Amino acid transporter. (542 aa)
AHRUncharacterized protein. (849 aa)
EP300E1A binding protein p300. (2425 aa)
SPTLC1Serine palmitoyltransferase long chain base subunit 1. (473 aa)
RNF5Ring finger protein 5. (180 aa)
CD4CD4 molecule. (487 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
RRM2Ribonucleotide reductase regulatory subunit M2. (393 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (407 aa)
SMSSpermine synthase. (476 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1152 aa)
GLDCGlycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1019 aa)
SAR1BSecretion associated Ras related GTPase 1B; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
MMP13Matrix metallopeptidase 13. (470 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1165 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1083 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1068 aa)
SPTLC3Serine palmitoyltransferase long chain base subunit 3. (552 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (618 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
SLC38A9Solute carrier family 38 member 9. (561 aa)
SLC6A14Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (639 aa)
KMOKynurenine 3-monooxygenase. (453 aa)
GOT2Aspartate aminotransferase. (430 aa)
AFMIDKynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (306 aa)
GPTGlutamic--pyruvic transaminase. (496 aa)
ASNSAsparagine synthetase [glutamine-hydrolyzing]. (561 aa)
SLC38A5Solute carrier family 38 member 5. (557 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (542 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (694 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1213 aa)
DHFRDHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (212 aa)
SLC1A7Amino acid transporter. (624 aa)
PHGDHD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (586 aa)
LARS2Leucyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (862 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (417 aa)
ARG1Arginase. (329 aa)
SESN2Sestrin 2. (516 aa)
KYNUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (469 aa)
SIRT4Sirtuin 4. (335 aa)
SLC1A2Amino acid transporter. (579 aa)
BCAT1Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (457 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1732 aa)
GLULGlutamine synthetase. (506 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (620 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1070 aa)
SLC43A1Solute carrier family 43 member 1. (687 aa)
CGASCyclic GMP-AMP synthase. (514 aa)
BCKDKProtein-serine/threonine kinase. (412 aa)
TDO2Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (406 aa)
IGF1Insulin like growth factor 1. (195 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
BMT2S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa)
TFEBTranscription factor EB. (478 aa)
LCKTyrosine-protein kinase. (520 aa)
ASPGAsparaginase. (571 aa)
SLC43A2Solute carrier family 43 member 2. (572 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (451 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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