47 items (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NME6	Nucleoside diphosphate kinase. (193 aa)
	UPB1	Beta-ureidopropionase 1. (384 aa)
	RRM2	Ribonucleotide reductase regulatory subunit M2. (393 aa)
	NT5C1A	5'-nucleotidase, cytosolic IA. (348 aa)
	CTPS2	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (586 aa)
	UMPS	Uridine monophosphate synthetase. (482 aa)
	PNP	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa)
	RRM1	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (792 aa)
	TYMS	Thymidylate synthetase. (316 aa)
	NME7	Nucleoside diphosphate kinase 7; Belongs to the NDK family. (376 aa)
	UPP1	Uridine phosphorylase 1. (354 aa)
	UCK1	PRK domain-containing protein. (401 aa)
	ENTPD1	Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family. (510 aa)
	ENPP3	Ectonucleotide pyrophosphatase/phosphodiesterase 3. (874 aa)
	DTYMK	Deoxythymidylate kinase. (232 aa)
	CAD	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. (2250 aa)
	DHODH	Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (395 aa)
	DCK	Deoxycytidine kinase. (269 aa)
	RRM2B	Ribonucleotide reductase regulatory TP53 inducible subunit M2B. (438 aa)
	NUDT2	Nudix hydrolase 2; Belongs to the Nudix hydrolase family. (147 aa)
	AK9	Uncharacterized protein. (419 aa)
	NT5C3B	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (300 aa)
	CMPK2	Cytidine/uridine monophosphate kinase 2. (442 aa)
	NT5C2	5'-nucleotidase, cytosolic II. (561 aa)
	DCTPP1	dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. (170 aa)
	DUT	dUTPase domain-containing protein. (225 aa)
	ENTPD3	Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family. (529 aa)
	ENTPD6	Ectonucleoside triphosphate diphosphohydrolase 6; Belongs to the GDA1/CD39 NTPase family. (461 aa)
	NT5C	5', 3'-nucleotidase, cytosolic. (205 aa)
	CDA	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa)
	DPYD	Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (1026 aa)
	NT5C3A	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (331 aa)
	NME4	Nucleoside diphosphate kinase. (187 aa)
	ENTPD4	Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (632 aa)
	NME3	Nucleoside diphosphate kinase. (174 aa)
	DCTD	CMP/dCMP-type deaminase domain-containing protein. (493 aa)
	NME2	Nucleoside diphosphate kinase. (152 aa)
	ENTPD8	Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family. (501 aa)
	UCK2	Uridine-cytidine kinase; Belongs to the uridine kinase family. (261 aa)
	NT5M	5',3'-nucleotidase, mitochondrial. (235 aa)
	NME1	Nucleoside diphosphate kinase. (178 aa)
	CTPS1	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (643 aa)
	DPYS	Dihydropyrimidinase. (535 aa)
	CMPK1	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (318 aa)
	NT5E	5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (587 aa)
	ENPP1	Ectonucleotide pyrophosphatase/phosphodiesterase 1. (1027 aa)
	RDH14	Uncharacterized protein. (770 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AK9	CMPK1	ENSFCAP00000023109	ENSFCAP00000054095	Uncharacterized protein.	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	0.958
AK9	CMPK2	ENSFCAP00000023109	ENSFCAP00000024568	Uncharacterized protein.	Cytidine/uridine monophosphate kinase 2.	0.956
AK9	CTPS1	ENSFCAP00000023109	ENSFCAP00000052595	Uncharacterized protein.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	0.939
AK9	CTPS2	ENSFCAP00000023109	ENSFCAP00000006056	Uncharacterized protein.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	0.939
AK9	DCK	ENSFCAP00000023109	ENSFCAP00000020325	Uncharacterized protein.	Deoxycytidine kinase.	0.922
AK9	DCTPP1	ENSFCAP00000023109	ENSFCAP00000026671	Uncharacterized protein.	dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.	0.919
AK9	DTYMK	ENSFCAP00000023109	ENSFCAP00000013251	Uncharacterized protein.	Deoxythymidylate kinase.	0.956
AK9	DUT	ENSFCAP00000023109	ENSFCAP00000027664	Uncharacterized protein.	dUTPase domain-containing protein.	0.937
AK9	ENPP1	ENSFCAP00000023109	ENSFCAP00000060910	Uncharacterized protein.	Ectonucleotide pyrophosphatase/phosphodiesterase 1.	0.903
AK9	ENPP3	ENSFCAP00000023109	ENSFCAP00000013106	Uncharacterized protein.	Ectonucleotide pyrophosphatase/phosphodiesterase 3.	0.903
AK9	ENTPD1	ENSFCAP00000023109	ENSFCAP00000012994	Uncharacterized protein.	Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family.	0.915
AK9	ENTPD3	ENSFCAP00000023109	ENSFCAP00000028159	Uncharacterized protein.	Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family.	0.915
AK9	ENTPD4	ENSFCAP00000023109	ENSFCAP00000040394	Uncharacterized protein.	Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family.	0.943
AK9	ENTPD6	ENSFCAP00000023109	ENSFCAP00000030020	Uncharacterized protein.	Ectonucleoside triphosphate diphosphohydrolase 6; Belongs to the GDA1/CD39 NTPase family.	0.923
AK9	ENTPD8	ENSFCAP00000023109	ENSFCAP00000047393	Uncharacterized protein.	Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family.	0.915
AK9	NME1	ENSFCAP00000023109	ENSFCAP00000050542	Uncharacterized protein.	Nucleoside diphosphate kinase.	0.944
AK9	NME2	ENSFCAP00000023109	ENSFCAP00000043707	Uncharacterized protein.	Nucleoside diphosphate kinase.	0.944
AK9	NME3	ENSFCAP00000023109	ENSFCAP00000042930	Uncharacterized protein.	Nucleoside diphosphate kinase.	0.944
AK9	NME4	ENSFCAP00000023109	ENSFCAP00000038558	Uncharacterized protein.	Nucleoside diphosphate kinase.	0.944
AK9	NME6	ENSFCAP00000023109	ENSFCAP00000000467	Uncharacterized protein.	Nucleoside diphosphate kinase.	0.944