(53 nodes) Arachidonic acid metabolism network (Felis catus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	PTGDS	Prostaglandin-H2 D-isomerase; Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possib [...] (364 aa)
	PLAAT3	Phospholipase A and acyltransferase 3. (162 aa)
	ALOX12	Arachidonate 12-lipoxygenase, 12S type. (664 aa)
	GGT1	Uncharacterized protein. (568 aa)
	PLA2G5	Phospholipase A(2). (158 aa)
	PLB1	Phospholipase B1. (1458 aa)
	PTGES3	Prostaglandin E synthase 3. (164 aa)
	LOC101083342	Phospholipase A2. (781 aa)
	LOC101091418	Uncharacterized protein. (314 aa)
	PTGES2	Prostaglandin E synthase 2. (373 aa)
	ALOX5	Arachidonate 5-lipoxygenase. (745 aa)
	EPHX2	Epoxide hydrolase 2. (554 aa)
	ALOX12B	Arachidonate 12-lipoxygenase, 12R type. (699 aa)
	CYP2U1	Cytochrome P450 family 2 subfamily U member 1; Belongs to the cytochrome P450 family. (544 aa)
	LTC4S	Leukotriene C4 synthase. (150 aa)
	M3WQB1_FELCA	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (283 aa)
	GPX5	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (222 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (604 aa)
	GPX8	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
	GGT5	Gamma-glutamyltransferase 5. (570 aa)
	PLA2G4D	Phospholipase A2. (814 aa)
	ENSFCAP00000027010	Uncharacterized protein. (425 aa)
	PLA2G4A	Phospholipase A2. (749 aa)
	PLA2G2E	Phospholipase A(2). (142 aa)
	GPX1	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (205 aa)
	PLA2G1B	Phospholipase A(2). (148 aa)
	LOC101084134	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (292 aa)
	CBR3	Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (277 aa)
	LOC101083875	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (292 aa)
	PLA2G2F	Phospholipase A(2). (211 aa)
	LOC105259649	Uncharacterized protein; Belongs to the cytochrome P450 family. (552 aa)
	CYP2E2	Uncharacterized protein; Belongs to the cytochrome P450 family. (495 aa)
	PTGIS	Prostacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (500 aa)
	LOC101094994	Uncharacterized protein; Belongs to the cytochrome P450 family. (510 aa)
	PTGES	Prostaglandin E synthase. (153 aa)
	GPX2	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (189 aa)
	GPX3	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (225 aa)
	LOC105260134	Uncharacterized protein; Belongs to the cytochrome P450 family. (498 aa)
	PLA2G3	Phospholipase A2 group III. (522 aa)
	HPGDS	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. (199 aa)
	PLA2G10	Phospholipase A(2). (162 aa)
	LTA4H	Leukotriene A(4) hydrolase; Belongs to the peptidase M1 family. (619 aa)
	PLA2G2C	Phospholipase A(2). (149 aa)
	ALOX15B	Arachidonate 15-lipoxygenase type B. (678 aa)
	GPX6	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (221 aa)
	PLA2G4E	Phospholipase A2. (862 aa)
	AKR1C3	Aldo_ket_red domain-containing protein. (419 aa)
	MRRF	Prostaglandin-endoperoxide synthase 1. (633 aa)
	CYP2J2	Cytochrome P450 family 2 subfamily J member 2; Belongs to the cytochrome P450 family. (502 aa)
	TBXAS1	Thromboxane A synthase 1; Belongs to the cytochrome P450 family. (558 aa)
	LOC101083281	Uncharacterized protein. (480 aa)
	PLA2G12B	Phospholipase A2 group XIIB. (255 aa)
	PLA2G2D	Phospholipase A(2). (145 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKR1C3	CYP2E2	ENSFCAP00000056294	ENSFCAP00000037780	Aldo_ket_red domain-containing protein.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.903
AKR1C3	HPGDS	ENSFCAP00000056294	ENSFCAP00000048270	Aldo_ket_red domain-containing protein.	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily.	0.917
AKR1C3	LOC101083875	ENSFCAP00000056294	ENSFCAP00000035650	Aldo_ket_red domain-containing protein.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.923
AKR1C3	LOC101084134	ENSFCAP00000056294	ENSFCAP00000033796	Aldo_ket_red domain-containing protein.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.923
AKR1C3	LOC105259649	ENSFCAP00000056294	ENSFCAP00000036747	Aldo_ket_red domain-containing protein.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.906
AKR1C3	LOC105260134	ENSFCAP00000056294	ENSFCAP00000041199	Aldo_ket_red domain-containing protein.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.906
AKR1C3	M3WQB1_FELCA	ENSFCAP00000056294	ENSFCAP00000016541	Aldo_ket_red domain-containing protein.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.923
AKR1C3	PTGDS	ENSFCAP00000056294	ENSFCAP00000000363	Aldo_ket_red domain-containing protein.	Prostaglandin-H2 D-isomerase; Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possib [...]	0.908
AKR1C3	PTGES	ENSFCAP00000056294	ENSFCAP00000038442	Aldo_ket_red domain-containing protein.	Prostaglandin E synthase.	0.482
AKR1C3	PTGES2	ENSFCAP00000056294	ENSFCAP00000011767	Aldo_ket_red domain-containing protein.	Prostaglandin E synthase 2.	0.406
AKR1C3	PTGS2	ENSFCAP00000056294	ENSFCAP00000020047	Aldo_ket_red domain-containing protein.	Prostaglandin-endoperoxide synthase 2.	0.439
ALOX12	ALOX12B	ENSFCAP00000001260	ENSFCAP00000014085	Arachidonate 12-lipoxygenase, 12S type.	Arachidonate 12-lipoxygenase, 12R type.	0.938
ALOX12	ALOX15B	ENSFCAP00000001260	ENSFCAP00000052319	Arachidonate 12-lipoxygenase, 12S type.	Arachidonate 15-lipoxygenase type B.	0.906
ALOX12	ALOX5	ENSFCAP00000001260	ENSFCAP00000012173	Arachidonate 12-lipoxygenase, 12S type.	Arachidonate 5-lipoxygenase.	0.905
ALOX12	CYP2E2	ENSFCAP00000001260	ENSFCAP00000037780	Arachidonate 12-lipoxygenase, 12S type.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.905
ALOX12	CYP2J2	ENSFCAP00000001260	ENSFCAP00000056975	Arachidonate 12-lipoxygenase, 12S type.	Cytochrome P450 family 2 subfamily J member 2; Belongs to the cytochrome P450 family.	0.909
ALOX12	CYP2U1	ENSFCAP00000001260	ENSFCAP00000014220	Arachidonate 12-lipoxygenase, 12S type.	Cytochrome P450 family 2 subfamily U member 1; Belongs to the cytochrome P450 family.	0.905
ALOX12	ENSFCAP00000027010	ENSFCAP00000001260	ENSFCAP00000027010	Arachidonate 12-lipoxygenase, 12S type.	Uncharacterized protein.	0.905
ALOX12	LOC101083281	ENSFCAP00000001260	ENSFCAP00000059879	Arachidonate 12-lipoxygenase, 12S type.	Uncharacterized protein.	0.905
ALOX12	LOC101083342	ENSFCAP00000001260	ENSFCAP00000006817	Arachidonate 12-lipoxygenase, 12S type.	Phospholipase A2.	0.902