STRINGSTRING
MTOR MTOR BAX BAX PRKCG PRKCG JAK1 JAK1 STAT3 STAT3 RPS6 RPS6 HRAS HRAS EIF4E1B EIF4E1B PDGFRB PDGFRB AKT3 AKT3 SHC3 SHC3 AKT1 AKT1 GAS6 GAS6 PDGFRA PDGFRA KDR KDR EIF4EBP1 EIF4EBP1 PIK3R1 PIK3R1 PRKCB PRKCB PRKCA PRKCA BRAF BRAF MAP2K2 MAP2K2 ERBB3 ERBB3 SHC2 SHC2 PDGFB PDGFB KRAS KRAS PTEN PTEN IGF1R IGF1R RPS6KB1 RPS6KB1 MAP2K1 MAP2K1 SOS1 SOS1 FOXO3 FOXO3 PDGFA PDGFA IL6R IL6R PIK3CD PIK3CD GRB2 GRB2 SOS2 SOS2 MAPK1 MAPK1 PIK3CB PIK3CB SHC4 SHC4 RAF1 RAF1 HGF HGF NRAS NRAS MAPK3 MAPK3 AXL AXL PIK3CA PIK3CA TGFA TGFA SRC SRC EGFR EGFR IGF1 IGF1 PLCG2 PLCG2 ARAF ARAF EIF4E EIF4E PIK3R2 PIK3R2 GSK3B GSK3B FGFR3 FGFR3 NRG1 NRG1 PIK3R3 PIK3R3 BAD BAD EIF4E2 EIF4E2 JAK2 JAK2 PDGFD PDGFD RPS6KB2 RPS6KB2 PLCG1 PLCG1 NF1 NF1 PDGFC PDGFC BCL2L1 BCL2L1 AKT2 AKT2 EGF EGF FGFR2 FGFR2 MET MET BCL2 BCL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
JAK1Tyrosine-protein kinase. (1157 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
RPS6Ribosomal protein S6. (315 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (213 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1131 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SHC3SHC adaptor protein 3. (587 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GAS6Growth arrest specific 6. (674 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1514 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (804 aa)
MAP2K2Protein kinase domain-containing protein. (549 aa)
ERBB3ERBB3. (1339 aa)
SHC2SHC adaptor protein 2. (583 aa)
PDGFBPlatelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (245 aa)
KRASUncharacterized protein. (380 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
FOXO3Forkhead box O3. (672 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
IL6RInterleukin 6 receptor. (468 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
SHC4SHC adaptor protein 4. (630 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
HGFHepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity). (728 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
AXLAXL receptor tyrosine kinase. (861 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TGFATransforming growth factor alpha. (192 aa)
SRCTyrosine-protein kinase. (678 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
IGF1Insulin like growth factor 1. (195 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1318 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (659 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (237 aa)
PIK3R2Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
GSK3BProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (433 aa)
FGFR3Fibroblast growth factor receptor. (805 aa)
NRG1Neuregulin 1. (713 aa)
PIK3R3Uncharacterized protein. (461 aa)
BADBCL2 associated agonist of cell death. (273 aa)
EIF4E2Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (358 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
PDGFDPlatelet derived growth factor D. (380 aa)
RPS6KB2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (497 aa)
PLCG1Phosphoinositide phospholipase C. (1391 aa)
NF1Neurofibromin 1. (2856 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
BCL2L1BCL2 like 1. (271 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1213 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1382 aa)
BCL2BCL2 apoptosis regulator. (237 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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