STRINGSTRING
MTOR MTOR ADCY6 ADCY6 BAX BAX NOTCH3 NOTCH3 HBEGF HBEGF MAPK10 MAPK10 HRAS HRAS ADCY3 ADCY3 AKT3 AKT3 SHC3 SHC3 CARM1 CARM1 AKT1 AKT1 E2F1 E2F1 ADCY4 ADCY4 ADCY8 ADCY8 NOTCH2 NOTCH2 PIK3R1 PIK3R1 E2F2 E2F2 MAPK11 MAPK11 BRAF BRAF MMP9 MMP9 MAP2K2 MAP2K2 DLL4 DLL4 NCOA3 NCOA3 SHC2 SHC2 LOC102900772 LOC102900772 KRAS KRAS IGF1R IGF1R SP1 SP1 CDK4 CDK4 ADCY9 ADCY9 PRKACA PRKACA NOTCH1 NOTCH1 ESR1 ESR1 CDKN1A CDKN1A JUN JUN RPS6KB1 RPS6KB1 MAP2K1 MAP2K1 SOS1 SOS1 PIK3CD PIK3CD GRB2 GRB2 MAPK14 MAPK14 RB1 RB1 SOS2 SOS2 MDM2 MDM2 MAPK1 MAPK1 JAG2 JAG2 PIK3CB PIK3CB ADCY7 ADCY7 CDKN2C CDKN2C SHC4 SHC4 MAPK12 MAPK12 RAF1 RAF1 NCOR1 NCOR1 PTK2 PTK2 NRAS NRAS MAPK3 MAPK3 DLL3 DLL3 PIK3CA PIK3CA MAPK8 MAPK8 MMP2 MMP2 PRKACB PRKACB SRC SRC EGFR EGFR IGF1 IGF1 ARAF ARAF ESR2 ESR2 PIK3R2 PIK3R2 GPER1 GPER1 MED1 MED1 CDKN1B CDKN1B LOC101100603 LOC101100603 FOS FOS PIK3R3 PIK3R3 BAD BAD MAPK9 MAPK9 CCND1 CCND1 ABCB11 ABCB11 GNAS GNAS RPS6KB2 RPS6KB2 ADCY2 ADCY2 ADCY1 ADCY1 BIK BIK ENSFCAP00000057780 ENSFCAP00000057780 JAG1 JAG1 DLL1 DLL1 ADCY5 ADCY5 AKT2 AKT2 BCL2 BCL2 E2F3 E2F3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1208 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
NOTCH3Notch receptor 3. (2323 aa)
HBEGFHeparin binding EGF like growth factor. (305 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SHC3SHC adaptor protein 3. (587 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (608 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
E2F1E2F transcription factor 1. (436 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1010 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
NOTCH2Notch receptor 2. (2493 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
E2F2E2F transcription factor 2. (442 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (804 aa)
MMP9Matrix metallopeptidase 9. (705 aa)
MAP2K2Protein kinase domain-containing protein. (549 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)
NCOA3Nuclear receptor coactivator. (1412 aa)
SHC2SHC adaptor protein 2. (583 aa)
LOC102900772Uncharacterized protein. (247 aa)
KRASUncharacterized protein. (380 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
SP1Sp1 transcription factor. (786 aa)
CDK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
NOTCH1Notch receptor 1. (2543 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa)
CDKN1ACyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
RB1RB transcriptional corepressor 1. (930 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (712 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1609 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
SHC4SHC adaptor protein 4. (630 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
NCOR1Nuclear receptor corepressor 1. (2515 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1112 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
DLL3Delta like canonical Notch ligand 3. (589 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
SRCTyrosine-protein kinase. (678 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
IGF1Insulin like growth factor 1. (195 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (659 aa)
ESR2Estrogen receptor 2. (574 aa)
PIK3R2Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. (198 aa)
LOC101100603PUM-HD domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (771 aa)
FOSProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa)
PIK3R3Uncharacterized protein. (461 aa)
BADBCL2 associated agonist of cell death. (273 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (312 aa)
ABCB11ATP binding cassette subfamily B member 11. (1339 aa)
GNASGNAS complex locus. (968 aa)
RPS6KB2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (497 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1135 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1148 aa)
BIKUncharacterized protein. (245 aa)
ENSFCAP00000057780Uncharacterized protein. (585 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1287 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (731 aa)
ADCY5Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1329 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
BCL2BCL2 apoptosis regulator. (237 aa)
E2F3E2F transcription factor 3. (523 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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