STRINGSTRING
BAX BAX MLH1 MLH1 PDPK1 PDPK1 AKT3 AKT3 MGST3 MGST3 AKT1 AKT1 LOC101096317 LOC101096317 MSH3 MSH3 MSH6 MSH6 MAP3K5 MAP3K5 TOP2A TOP2A POLH POLH PIK3R1 PIK3R1 XIAP XIAP BRCA1 BRCA1 MSH2 MSH2 BIRC3 BIRC3 CUTC CUTC GSTM3 GSTM3 ATP7A ATP7A GSTO1 GSTO1 CASP9 CASP9 LOC101083370 LOC101083370 TOP2B TOP2B CDKN1A CDKN1A MGST2 MGST2 LOC101084793 LOC101084793 LOC101100947 LOC101100947 PIK3CD PIK3CD MDM2 MDM2 MAPK1 MAPK1 ATM ATM FAS FAS PIK3CB PIK3CB GSTM4 GSTM4 LOC101083114 LOC101083114 CASP3 CASP3 ATP7B ATP7B FASLG FASLG GSTT4 GSTT4 MAPK3 MAPK3 GSTA4 GSTA4 SLC31A1 SLC31A1 PIK3CA PIK3CA BIRC5 BIRC5 REV3L REV3L ERCC1 ERCC1 PIK3R2 PIK3R2 FADD FADD BBC3 BBC3 PIK3R3 PIK3R3 APAF1 APAF1 BAD BAD PMAIP1 PMAIP1 CASP8 CASP8 XPA XPA BID BID GSTP1 GSTP1 BCL2L1 BCL2L1 AKT2 AKT2 MGST1 MGST1 BCL2 BCL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BAXBCL2 associated X, apoptosis regulator. (192 aa)
MLH1MutL homolog 1. (758 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MGST3Microsomal glutathione S-transferase 3. (190 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LOC101096317Uncharacterized protein; Belongs to the GST superfamily. (223 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1125 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1359 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1366 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1534 aa)
POLHDNA polymerase eta. (712 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
XIAPX-linked inhibitor of apoptosis. (454 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1872 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
BIRC3Baculoviral IAP repeat containing 3. (624 aa)
CUTCATP binding cassette subfamily C member 2. (1542 aa)
GSTM3Glutathione S-transferase. (226 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
GSTO1Glutathione S-transferase omega 1. (241 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (451 aa)
LOC101083370Uncharacterized protein. (257 aa)
TOP2BDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1621 aa)
CDKN1ACyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa)
MGST2Microsomal glutathione S-transferase 2. (146 aa)
LOC101084793Uncharacterized protein. (222 aa)
LOC101100947Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (712 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa)
FASUncharacterized protein. (314 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
GSTM4Glutathione S-transferase mu 4; Belongs to the GST superfamily. (212 aa)
LOC101083114Uncharacterized protein; Belongs to the GST superfamily. (296 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa)
ATP7BATPase copper transporting beta. (1470 aa)
FASLGTumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa)
GSTT4Glutathione S-transferase theta 4; Belongs to the GST superfamily. (274 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
GSTA4Glutathione S-transferase alpha 4. (222 aa)
SLC31A1Solute carrier family 31 member 1. (191 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
BIRC5Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] (142 aa)
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (3131 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (329 aa)
PIK3R2Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (215 aa)
BBC3Uncharacterized protein. (193 aa)
PIK3R3Uncharacterized protein. (461 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1250 aa)
BADBCL2 associated agonist of cell death. (273 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (479 aa)
XPAXPA, DNA damage recognition and repair factor. (280 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (205 aa)
GSTP1Uncharacterized protein; Belongs to the GST superfamily. (438 aa)
BCL2L1BCL2 like 1. (271 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
MGST1Microsomal glutathione S-transferase 1. (176 aa)
BCL2BCL2 apoptosis regulator. (237 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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