(73 nodes) PPAR signaling pathway network (Felis catus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PCK1	Phosphoenolpyruvate carboxykinase 1. (622 aa)
	OLR1	Oxidized low density lipoprotein receptor 1. (274 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (558 aa)
	ACOX2	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (681 aa)
	SLC27A5	Solute carrier family 27 member 5. (687 aa)
	ACSL1	Acyl-CoA synthetase long chain family member 1. (698 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (468 aa)
	ACSBG1	Acyl-CoA synthetase bubblegum family member 1. (815 aa)
	CPT1C	Carnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (803 aa)
	EHHADH	Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (806 aa)
	CYP7A1	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (501 aa)
	UCP1	Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
	SLC27A6	Solute carrier family 27 member 6. (619 aa)
	RXRG	Retinoid X receptor gamma. (463 aa)
	SLC27A2	Solute carrier family 27 member 2. (620 aa)
	ACSL3	Acyl-CoA synthetase long chain family member 3. (720 aa)
	ME3	Malic enzyme. (604 aa)
	HMGCS1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (537 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (283 aa)
	ANGPTL4	Angiopoietin like 4. (414 aa)
	ACOX3	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (700 aa)
	ILK	Integrin linked kinase. (451 aa)
	NR1I3	Nuclear receptor subfamily 1 group I member 3. (423 aa)
	MMP1	Matrix metallopeptidase 1. (471 aa)
	PLIN5	Perilipin; Belongs to the perilipin family. (460 aa)
	APOA1	Apolipoprotein A1. (295 aa)
	FABP2	Fatty acid binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	ACOX1	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (661 aa)
	FABP1	Fatty acid binding protein 1. (127 aa)
	APOC3	Apolipoprotein C3. (116 aa)
	FABP4	Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	SCP2	Sterol carrier protein 2; Belongs to the thiolase-like superfamily. Thiolase family. (551 aa)
	CYP8B1	Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. (501 aa)
	AQP7	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (350 aa)
	ACADL	Acyl-CoA dehydrogenase long chain. (430 aa)
	FADS2	Fatty acid desaturase 2. (444 aa)
	FABP3	Fatty acid binding protein 3; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (133 aa)
	SCD5	Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (330 aa)
	LOC101088630	ACB domain-containing protein. (87 aa)
	ACADM	Acyl-CoA dehydrogenase medium chain. (445 aa)
	ENSFCAP00000027010	Uncharacterized protein. (425 aa)
	PPARD	Peroxisome proliferator activated receptor delta. (464 aa)
	CPT1B	Carnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
	CD36	CD36 molecule; Belongs to the CD36 family. (472 aa)
	ME1	Malic enzyme. (572 aa)
	ACSL4	Acyl-CoA synthetase long chain family member 4. (711 aa)
	LOC101094994	Uncharacterized protein; Belongs to the cytochrome P450 family. (510 aa)
	CPT2	Carnitine palmitoyltransferase 2; Belongs to the carnitine/choline acetyltransferase family. (696 aa)
	ACSL6	AMP-binding domain-containing protein. (722 aa)
	PLTP	Phospholipid transfer protein. (623 aa)
	HMGCS2	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
	GK2	Glycerol kinase 2; Belongs to the FGGY kinase family. (553 aa)
	LOC101085801	Uncharacterized protein. (467 aa)
	LOC101099553	Uncharacterized protein; Belongs to the FGGY kinase family. (537 aa)
	PLIN1	Perilipin; Belongs to the perilipin family. (522 aa)
	APOA5	Apolipoprotein A5. (370 aa)
	PCK2	Phosphoenolpyruvate carboxykinase 2, mitochondrial. (620 aa)
	DBI	Diazepam binding inhibitor, acyl-CoA binding protein. (96 aa)
	RXRA	Retinoid X receptor alpha. (654 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (498 aa)
	ACSL5	Acyl-CoA synthetase long chain family member 5. (670 aa)
	SLC27A1	Solute carrier family 27 member 1. (796 aa)
	ACAA1	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (456 aa)
	CPT1A	Carnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
	FABP5	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (184 aa)
	LOC102900010	AMP-binding domain-containing protein. (758 aa)
	LPL	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans (By similarity). (482 aa)
	CYP27A1	Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family. (548 aa)
	FABP6	Fatty acid binding protein 6. (148 aa)
	FABP7	Fatty acid binding protein 7; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (157 aa)
	PLIN2	Perilipin; Belongs to the perilipin family. (447 aa)
	LOC101083281	Uncharacterized protein. (480 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAA1	ACADL	ENSFCAP00000053472	ENSFCAP00000019498	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-CoA dehydrogenase long chain.	0.973
ACAA1	ACADM	ENSFCAP00000053472	ENSFCAP00000025061	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-CoA dehydrogenase medium chain.	0.968
ACAA1	ACOX1	ENSFCAP00000053472	ENSFCAP00000016791	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.989
ACAA1	ACOX2	ENSFCAP00000053472	ENSFCAP00000002039	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.845
ACAA1	ACOX3	ENSFCAP00000053472	ENSFCAP00000014183	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.975
ACAA1	ACSBG1	ENSFCAP00000053472	ENSFCAP00000005498	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-CoA synthetase bubblegum family member 1.	0.691
ACAA1	ACSL1	ENSFCAP00000053472	ENSFCAP00000004713	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-CoA synthetase long chain family member 1.	0.655
ACAA1	ACSL5	ENSFCAP00000053472	ENSFCAP00000052407	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-CoA synthetase long chain family member 5.	0.609
ACAA1	ACSL6	ENSFCAP00000053472	ENSFCAP00000041452	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	AMP-binding domain-containing protein.	0.603
ACAA1	CPT1B	ENSFCAP00000053472	ENSFCAP00000028739	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Carnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family.	0.471
ACAA1	CPT2	ENSFCAP00000053472	ENSFCAP00000040821	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Carnitine palmitoyltransferase 2; Belongs to the carnitine/choline acetyltransferase family.	0.700
ACAA1	DBI	ENSFCAP00000053472	ENSFCAP00000047938	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Diazepam binding inhibitor, acyl-CoA binding protein.	0.569
ACAA1	EHHADH	ENSFCAP00000053472	ENSFCAP00000006616	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.986
ACAA1	HMGCS1	ENSFCAP00000053472	ENSFCAP00000011120	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.986
ACAA1	HMGCS2	ENSFCAP00000053472	ENSFCAP00000041858	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.989
ACAA1	LOC101088630	ENSFCAP00000053472	ENSFCAP00000024663	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	ACB domain-containing protein.	0.478
ACAA1	LOC102900010	ENSFCAP00000053472	ENSFCAP00000054345	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	AMP-binding domain-containing protein.	0.466
ACAA1	ME1	ENSFCAP00000053472	ENSFCAP00000031907	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Malic enzyme.	0.415
ACAA1	ME3	ENSFCAP00000053472	ENSFCAP00000010970	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Malic enzyme.	0.415
ACAA1	SCP2	ENSFCAP00000053472	ENSFCAP00000017832	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Sterol carrier protein 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.969