STRINGSTRING
MTOR MTOR AREG AREG HBEGF HBEGF PRKCG PRKCG NCK2 NCK2 STAT5B STAT5B MAPK10 MAPK10 HRAS HRAS AKT3 AKT3 PAK1 PAK1 SHC3 SHC3 AKT1 AKT1 ABL1 ABL1 ABL2 ABL2 CRKL CRKL EIF4EBP1 EIF4EBP1 PIK3R1 PIK3R1 PRKCB PRKCB MAP2K4 MAP2K4 PRKCA PRKCA BRAF BRAF MAP2K2 MAP2K2 ERBB3 ERBB3 SHC2 SHC2 KRAS KRAS PAK2 PAK2 PAK4 PAK4 CBL CBL EREG EREG CDKN1A CDKN1A JUN JUN RPS6KB1 RPS6KB1 MAP2K1 MAP2K1 SOS1 SOS1 PIK3CD PIK3CD GRB2 GRB2 SOS2 SOS2 MAPK1 MAPK1 CBLB CBLB PIK3CB PIK3CB SHC4 SHC4 PAK6 PAK6 PAK5 PAK5 RAF1 RAF1 BTC BTC PTK2 PTK2 NRAS NRAS MAPK3 MAPK3 NRG3 NRG3 PIK3CA PIK3CA MAPK8 MAPK8 TGFA TGFA SRC SRC EGFR EGFR PLCG2 PLCG2 ERBB4 ERBB4 ARAF ARAF PIK3R2 PIK3R2 GSK3B GSK3B CDKN1B CDKN1B CAMK2B CAMK2B NRG1 NRG1 CRK CRK MYC MYC MAP2K7 MAP2K7 PIK3R3 PIK3R3 BAD BAD PAK3 PAK3 MAPK9 MAPK9 RPS6KB2 RPS6KB2 PLCG1 PLCG1 STAT5A STAT5A RPS14 RPS14 ELK1 ELK1 AKT2 AKT2 EGF EGF CAMK2D CAMK2D
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa)
AREGAmphiregulin. (323 aa)
HBEGFHeparin binding EGF like growth factor. (305 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
NCK2Cytoplasmic protein. (380 aa)
STAT5BSignal transducer and activator of transcription. (786 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
SHC3SHC adaptor protein 3. (587 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ABL1Tyrosine-protein kinase. (1150 aa)
ABL2Tyrosine-protein kinase. (1160 aa)
CRKLCRK like proto-oncogene, adaptor protein. (342 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (411 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (804 aa)
MAP2K2Protein kinase domain-containing protein. (549 aa)
ERBB3ERBB3. (1339 aa)
SHC2SHC adaptor protein 2. (583 aa)
KRASUncharacterized protein. (380 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
PAK4Non-specific serine/threonine protein kinase. (592 aa)
CBLCbl proto-oncogene. (902 aa)
EREGEpiregulin. (169 aa)
CDKN1ACyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
CBLBCbl proto-oncogene B. (1182 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
SHC4SHC adaptor protein 4. (630 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
PAK5Non-specific serine/threonine protein kinase. (725 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
BTCBetacellulin. (194 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1112 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
NRG3Neuregulin 3. (720 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TGFATransforming growth factor alpha. (192 aa)
SRCTyrosine-protein kinase. (678 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1318 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (659 aa)
PIK3R2Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
GSK3BProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (433 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. (198 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (748 aa)
NRG1Neuregulin 1. (713 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (439 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
PIK3R3Uncharacterized protein. (461 aa)
BADBCL2 associated agonist of cell death. (273 aa)
PAK3P21 (RAC1) activated kinase 3. (589 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
RPS6KB2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (497 aa)
PLCG1Phosphoinositide phospholipase C. (1391 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
RPS14Calcium/calmodulin dependent protein kinase II alpha. (566 aa)
ELK1ETS transcription factor ELK1. (487 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1213 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (544 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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