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| | FGF6 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | NTF4 | Neurotrophin 4; Belongs to the NGF-beta family. (210 aa) |
| | BRAP | BRCA1 associated protein. (592 aa) |
| | RASGRP4 | RAS guanyl releasing protein 4. (671 aa) |
| | PLAAT3 | Phospholipase A and acyltransferase 3. (162 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa) |
| | FLT4 | Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1405 aa) |
| | RAB5C | Uncharacterized protein. (216 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (467 aa) |
| | KSR2 | Kinase suppressor of ras 2. (949 aa) |
| | TIAM1 | T cell lymphoma invasion and metastasis 1. (1591 aa) |
| | TEK | TEK receptor tyrosine kinase. (1125 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | KIT | Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (979 aa) |
| | CSF1R | Macrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulat [...] (1213 aa) |
| | PDGFRB | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1131 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | PAK1 | Non-specific serine/threonine protein kinase. (544 aa) |
| | SHC3 | SHC adaptor protein 3. (587 aa) |
| | FLT3 | Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1022 aa) |
| | PLA2G5 | Phospholipase A(2). (158 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | ABL1 | Tyrosine-protein kinase. (1150 aa) |
| | ABL2 | Tyrosine-protein kinase. (1160 aa) |
| | PLA1A | Phospholipase A1 member A. (694 aa) |
| | CALML6 | Calmodulin like 6. (180 aa) |
| | PLCE1 | Phosphoinositide phospholipase C. (2301 aa) |
| | CALML4 | Calmodulin like 4. (196 aa) |
| | NTF3 | Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa) |
| | LOC101083342 | Phospholipase A2. (781 aa) |
| | FGF21 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | GAB2 | GRB2 associated binding protein 2. (678 aa) |
| | ETS2 | Protein C-ets-2; Transcription factor; Belongs to the ETS family. (469 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (989 aa) |
| | VEGFC | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa) |
| | REL | REL proto-oncogene, NF-kB subunit. (583 aa) |
| | PLD2 | Phospholipase. (984 aa) |
| | NTRK2 | Tyrosine-protein kinase receptor. (838 aa) |
| | PDGFRA | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa) |
| | KSR1 | Kinase suppressor of ras 1. (928 aa) |
| | RIN1 | Ras and Rab interactor 1. (790 aa) |
| | RRAS2 | Uncharacterized protein. (204 aa) |
| | RASGRP3 | RAS guanyl releasing protein 3. (692 aa) |
| | KDR | Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1514 aa) |
| | EPHA2 | EPH receptor A2. (936 aa) |
| | GNG13 | G protein subunit gamma 13. (67 aa) |
| | ZAP70 | Tyrosine-protein kinase. (619 aa) |
| | CSF1 | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (569 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (725 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa) |
| | GNB3 | G protein subunit beta 3. (339 aa) |
| | RGL1 | Ral guanine nucleotide dissociation stimulator like 1. (873 aa) |
| | RAB5B | RAB5B, member RAS oncogene family. (215 aa) |
| | MAP2K2 | Protein kinase domain-containing protein. (549 aa) |
| | GRIN2A | Glutamate ionotropic receptor NMDA type subunit 2A. (1464 aa) |
| | ANGPT2 | Angiopoietin 2. (494 aa) |
| | SHC2 | SHC adaptor protein 2. (583 aa) |
| | PDGFB | Platelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (245 aa) |
| | FGFR4 | Fibroblast growth factor receptor. (830 aa) |
| | RASAL3 | RAS protein activator like 3. (1012 aa) |
| | KRAS | Uncharacterized protein. (380 aa) |
| | IGF1R | Tyrosine-protein kinase receptor. (1367 aa) |
| | CALM2 | Calmodulin 2; Belongs to the calmodulin family. (149 aa) |
| | PAK2 | Non-specific serine/threonine protein kinase. (524 aa) |
| | FGF16 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | PAK4 | Non-specific serine/threonine protein kinase. (592 aa) |
| | RHOA | Ras homolog family member A. (193 aa) |
| | GNB1 | G protein subunit beta 1. (340 aa) |
| | GNGT1 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa) |
| | RALA | RAS like proto-oncogene A. (206 aa) |
| | PRKACA | Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa) |
| | FGF7 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa) |
| | RALB | RAS like proto-oncogene B. (206 aa) |
| | STK4 | Serine/threonine kinase 4. (487 aa) |
| | RRAS | RAS related. (218 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (423 aa) |
| | RAP1A | RAP1A, member of RAS oncogene family. (184 aa) |
| | GNB2 | G protein subunit beta 2. (340 aa) |
| | GNG14 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | LOC101088748 | Uncharacterized protein. (778 aa) |
| | FGF9 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | ANGPT4 | Angiopoietin 4. (499 aa) |
| | FLT3LG | Fms related tyrosine kinase 3 ligand. (291 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa) |
| | RASGRF2 | Ras protein specific guanine nucleotide releasing factor 2. (1239 aa) |
| | PDGFA | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | GRB2 | Growth factor receptor bound protein 2. (217 aa) |
| | CDC42-2 | Uncharacterized protein. (191 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa) |
| | RAP1B | RAP1B, member of RAS oncogene family. (187 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa) |
| | PLA2G4D | Phospholipase A2. (814 aa) |
| | GNB4 | G protein subunit beta 4. (340 aa) |
| | GNG11 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa) |
| | GNGT2 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa) |
| | PLA2G4A | Phospholipase A2. (749 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | FLT1 | Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa) |
| | CALML3 | Calmodulin like 3; Belongs to the calmodulin family. (149 aa) |
| | LOC101097703 | EF-hand domain-containing protein; Belongs to the calmodulin family. (86 aa) |
| | SHC4 | SHC adaptor protein 4. (630 aa) |
| | PAK6 | Non-specific serine/threonine protein kinase. (681 aa) |
| | PTPN11 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa) |
| | INSR | Tyrosine-protein kinase receptor. (1381 aa) |
| | PAK5 | Non-specific serine/threonine protein kinase. (725 aa) |
| | FOXO4 | Forkhead box O4. (515 aa) |
| | PLA2G2E | Phospholipase A(2). (142 aa) |
| | RASA2 | RAS p21 protein activator 2. (854 aa) |
| | EXOC2 | Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (924 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
| | FGFR1 | Fibroblast growth factor receptor. (852 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa) |
| | FGF4 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa) |
| | FASLG | Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa) |
| | PLA2G1B | Phospholipase A(2). (148 aa) |
| | GNG3 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa) |
| | HGF | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity). (728 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | PLA2G2F | Phospholipase A(2). (211 aa) |
| | PLD1 | Phospholipase. (1074 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | GNG5 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa) |
| | MRAS | Muscle RAS oncogene homolog. (254 aa) |
| | FGF19 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa) |
| | PRKACB | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa) |
| | RASSF1 | Ras association domain family member 1. (344 aa) |
| | TGFA | Transforming growth factor alpha. (192 aa) |
| | RASA1 | RAS p21 protein activator 1. (1039 aa) |
| | RASA4B | Uncharacterized protein. (801 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1209 aa) |
| | EFNA5 | Ephrin A5; Belongs to the ephrin family. (228 aa) |
| | IGF1 | Insulin like growth factor 1. (195 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1318 aa) |
| | HTR7 | 5-hydroxytryptamine receptor 7; Belongs to the G-protein coupled receptor 1 family. (442 aa) |
| | EFNA4 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. (314 aa) |
| | RALGDS | Uncharacterized protein. (885 aa) |
| | PIK3R2 | Phosphoinositide-3-kinase regulatory subunit 2. (726 aa) |
| | ENSFCAP00000043586 | Uncharacterized protein. (261 aa) |
| | FGFR3 | Fibroblast growth factor receptor. (805 aa) |
| | FGF20 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa) |
| | NGFR | Nerve growth factor receptor. (421 aa) |
| | RASGRP2 | RAS guanyl releasing protein 2. (615 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (760 aa) |
| | GRIN2B | Glutamate ionotropic receptor NMDA type subunit 2B. (1486 aa) |
| | FGF5 | Fibroblast growth factor 5. (279 aa) |
| | NGF | Nerve growth factor; Belongs to the NGF-beta family. (259 aa) |
| | PGF | Placental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa) |
| | RASAL1 | RAS protein activator like 1. (812 aa) |
| | RAB5A | RAB5A, member RAS oncogene family. (240 aa) |
| | PIK3R3 | Uncharacterized protein. (461 aa) |
| | ANGPT1 | Angiopoietin 1. (498 aa) |
| | NTRK1 | Tyrosine-protein kinase receptor. (770 aa) |
| | FGF3 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (229 aa) |
| | EFNA2 | Ephrin A2; Belongs to the ephrin family. (263 aa) |
| | GNG12 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa) |
| | BAD | BCL2 associated agonist of cell death. (273 aa) |
| | PAK3 | P21 (RAC1) activated kinase 3. (589 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | PLA2G3 | Phospholipase A2 group III. (522 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (555 aa) |
| | FGF18 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (326 aa) |
| | GNG8 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa) |
| | SHOC2 | SHOC2 leucine rich repeat scaffold protein. (582 aa) |
| | FGF23 | Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa) |
| | RASSF5 | Ras association domain family member 5. (425 aa) |
| | BDNF | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (255 aa) |
| | SYNGAP1 | Synaptic Ras GTPase activating protein 1. (1345 aa) |
| | PLA2G10 | Phospholipase A(2). (162 aa) |
| | GNG10 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa) |
| | EFNA3 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. (237 aa) |
| | PLA2G2C | Phospholipase A(2). (149 aa) |
| | RALBP1 | RalA binding protein 1. (659 aa) |
| | PDGFD | Platelet derived growth factor D. (380 aa) |
| | RASAL2 | RAS protein activator like 2. (1459 aa) |
| | FGF17 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (285 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | RASGRF1 | Ras protein specific guanine nucleotide releasing factor 1. (1312 aa) |
| | FGF22 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (271 aa) |
| | PLA2G4E | Phospholipase A2. (862 aa) |
| | PLCG1 | Phosphoinositide phospholipase C. (1391 aa) |
| | RASGRP1 | RAS guanyl releasing protein 1. (877 aa) |
| | NF1 | Neurofibromin 1. (2856 aa) |
| | GRIN1 | Glutamate ionotropic receptor NMDA type subunit 1. (1008 aa) |
| | RAC2 | Rac family small GTPase 2. (234 aa) |
| | PDGFC | Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa) |
| | ETS1 | ETS proto-oncogene 1, transcription factor. (503 aa) |
| | ELK1 | ETS transcription factor ELK1. (487 aa) |
| | AFDN | Afadin, adherens junction formation factor. (1873 aa) |
| | BCL2L1 | BCL2 like 1. (271 aa) |
| | LOC111559549 | Ig-like domain-containing protein. (247 aa) |
| | ARF6 | Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (140 aa) |
| | GNG2 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (152 aa) |
| | RAPGEF5 | Rap guanine nucleotide exchange factor 5. (889 aa) |
| | GNB5 | G protein subunit beta 5. (403 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase. (571 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1213 aa) |
| | KITLG | Soluble KIT ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity). (274 aa) |
| | FGFR2 | Fibroblast growth factor receptor. (841 aa) |
| | MET | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1382 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (774 aa) |
| | PLA2G12B | Phospholipase A2 group XIIB. (255 aa) |
| | GNG4 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (250 aa) |
| | PLA2G2D | Phospholipase A(2). (145 aa) |
