STRINGSTRING
ADCY6 ADCY6 CHRM1 CHRM1 PDE3A PDE3A FSHR FSHR CAMK4 CAMK4 GLI1 GLI1 VIP VIP MAPK10 MAPK10 TIAM1 TIAM1 NPR1 NPR1 F2R F2R ADCY3 ADCY3 POMC POMC AKT3 AKT3 CACNA1F CACNA1F PAK1 PAK1 SSTR5 SSTR5 CACNA1S CACNA1S SSTR2 SSTR2 PDE4A PDE4A AKT1 AKT1 EP300 EP300 VAV1 VAV1 HCN4 HCN4 PPARA PPARA PLN PLN ADCY4 ADCY4 NPY1R NPY1R CALML6 CALML6 PLCE1 PLCE1 CREBBP CREBBP GLP1R GLP1R ADCY8 ADCY8 CALML4 CALML4 NFKBIA NFKBIA GNAI2 GNAI2 GNAI1 GNAI1 NFKB1 NFKB1 ATP2B1 ATP2B1 HTR1B HTR1B ADRB2 ADRB2 PLD2 PLD2 GABBR2 GABBR2 FFAR2 FFAR2 GIP GIP CNGA1 CNGA1 ABCC4 ABCC4 LHCGR LHCGR ATP1B1 ATP1B1 SSTR1 SSTR1 RRAS2 RRAS2 SLC9A1 SLC9A1 TSHB TSHB PIK3R1 PIK3R1 PPP1CC PPP1CC GHRL GHRL GHSR GHSR VAV2 VAV2 HTR1D HTR1D GLI3 GLI3 ATP1A3 ATP1A3 BRAF BRAF HTR1A HTR1A EDN2 EDN2 MAP2K2 MAP2K2 CREB3L3 CREB3L3 GRIN2A GRIN2A FSHB FSHB EDN1 EDN1 ADCY10 ADCY10 ACOX3 ACOX3 HCAR2 HCAR2 LOC102900772 LOC102900772 GRIN3A GRIN3A CREB3L1 CREB3L1 GRIN2D GRIN2D HCN2 HCN2 CALM2 CALM2 ACOX1 ACOX1 PPP1CA PPP1CA CHRM2 CHRM2 LIPE LIPE RHOA RHOA CNGA2 CNGA2 ADCY9 ADCY9 PRKACA PRKACA ATP1B3 ATP1B3 PDE3B PDE3B GPR119 GPR119 PPP1R12A PPP1R12A MC2R MC2R RRAS RRAS JUN JUN RAP1A RAP1A MAP2K1 MAP2K1 ADORA2A ADORA2A CNGA4 CNGA4 SUCNR1 SUCNR1 PIK3CD PIK3CD ARAP3 ARAP3 OXT OXT LHB LHB ORAI1 ORAI1 ATP2A2 ATP2A2 M3XCZ6_FELCA M3XCZ6_FELCA HTR1F HTR1F HTR6 HTR6 RAP1B RAP1B MAPK1 MAPK1 MYL9 MYL9 BGN BGN CGA CGA PIK3CB PIK3CB OXTR OXTR CALML3 CALML3 ATP2B2 ATP2B2 GNAI3 GNAI3 SST SST CNGB3 CNGB3 ADCY7 ADCY7 CACNA1C CACNA1C TSHR TSHR LOC101097703 LOC101097703 ATP2B4 ATP2B4 ATP1A1 ATP1A1 ADORA1 ADORA1 RAF1 RAF1 CREB5 CREB5 DRD5 DRD5 MAPK3 MAPK3 GRIA1 GRIA1 GRIA2 GRIA2 RAPGEF4 RAPGEF4 PTGER3 PTGER3 ROCK1 ROCK1 HHIP HHIP PLD1 PLD1 PIK3CA PIK3CA RAPGEF3 RAPGEF3 PPP1CB PPP1CB MAPK8 MAPK8 GCG GCG PRKACB PRKACB EDNRA EDNRA CFTR CFTR ADRB1 ADRB1 PDE10A PDE10A ATP2A1 ATP2A1 PIK3R2 PIK3R2 ENSFCAP00000043586 ENSFCAP00000043586 GIPR GIPR CAMK2B CAMK2B PTCH1 PTCH1 GRIN2B GRIN2B SOX9 SOX9 ATP1B4 ATP1B4 CNGA3 CNGA3 FOS FOS VAV3 VAV3 HCAR1 HCAR1 PIK3R3 PIK3R3 HTR4 HTR4 BAD BAD MAPK9 MAPK9 RELA RELA GRIA3 GRIA3 DRD1 DRD1 ATP2A3 ATP2A3 BDNF BDNF PDE4C PDE4C CACNA1D CACNA1D GNAS GNAS NFATC1 NFATC1 RYR2 RYR2 ADCY2 ADCY2 CREB3 CREB3 GRIN1 GRIN1 ADCY1 ADCY1 NPPA NPPA RAC2 RAC2 AMH AMH EDN3 EDN3 RPS14 RPS14 PPP1R1B PPP1R1B GRIN2C GRIN2C GRIA4 GRIA4 AFDN AFDN LOC101090105 LOC101090105 ROCK2 ROCK2 CREB3L2 CREB3L2 PDE4D PDE4D ATP1A4 ATP1A4 ADCY5 ADCY5 AKT2 AKT2 FXYD2 FXYD2 CAMK2D CAMK2D PDE4B PDE4B
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1208 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (460 aa)
PDE3APhosphodiesterase. (1139 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (692 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV. (638 aa)
GLI1GLI family zinc finger 1. (1105 aa)
VIPVasoactive intestinal peptide. (170 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1591 aa)
NPR1Guanylate cyclase. (1063 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
POMCProopiomelanocortin. (258 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1984 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
SSTR5Somatostatin receptor 5; Belongs to the G-protein coupled receptor 1 family. (366 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1871 aa)
SSTR2Somatostatin receptor type 2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
PDE4APhosphodiesterase. (868 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
EP300E1A binding protein p300. (2425 aa)
VAV1Vav guanine nucleotide exchange factor 1. (846 aa)
HCN4Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1202 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1010 aa)
NPY1RNeuropeptide Y receptor Y1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
CALML6Calmodulin like 6. (180 aa)
PLCE1Phosphoinositide phospholipase C. (2301 aa)
CREBBPCREB binding protein. (2444 aa)
GLP1RGlucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (454 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
CALML4Calmodulin like 4. (196 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
GNAI2G protein subunit alpha i2. (436 aa)
GNAI1G protein subunit alpha i1. (354 aa)
NFKB1Nuclear factor kappa B subunit 1. (989 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
HTR1B5-hydroxytryptamine receptor 1B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopami [...] (389 aa)
ADRB2Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine (By similarity). Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily. (418 aa)
PLD2Phospholipase. (984 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (941 aa)
FFAR2Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (333 aa)
GIPGLUCAGON domain-containing protein. (222 aa)
CNGA1Cyclic nucleotide gated channel subunit alpha 1. (695 aa)
ABCC4ATP binding cassette subfamily C member 4. (1493 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (700 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
SSTR1Somatostatin receptor 1; Belongs to the G-protein coupled receptor 1 family. (391 aa)
RRAS2Uncharacterized protein. (204 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (759 aa)
TSHBThyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism. (140 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
GHRLAppetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family. (117 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
HTR1D5-hydroxytryptamine receptor 1D. (377 aa)
GLI3GLI family zinc finger 3. (1578 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (804 aa)
HTR1A5-hydroxytryptamine receptor 1A. (422 aa)
EDN2Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides. Belongs to the endothelin/sarafotoxin family. (178 aa)
MAP2K2Protein kinase domain-containing protein. (549 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (448 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
FSHBFollicle stimulating hormone subunit beta. (129 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (201 aa)
ADCY10Adenylate cyclase 10. (1608 aa)
ACOX3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (700 aa)
HCAR2Hydroxycarboxylic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
LOC102900772Uncharacterized protein. (247 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1116 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (1338 aa)
HCN2Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2. (895 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (149 aa)
ACOX1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (661 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (466 aa)
LIPELipase E, hormone sensitive type. (772 aa)
RHOARas homolog family member A. (193 aa)
CNGA2Cyclic nucleotide gated channel subunit alpha 2. (667 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (280 aa)
PDE3BPhosphodiesterase. (1122 aa)
GPR119G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family. (336 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1029 aa)
MC2RMelanocortin 2 receptor. (297 aa)
RRASRAS related. (218 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
CNGA4Cyclic nucleotide gated channel subunit alpha 4. (575 aa)
SUCNR1Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (353 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ARAP3ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3. (1544 aa)
OXTOxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (125 aa)
LHBLutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. (143 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (406 aa)
ATP2A2Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] (1006 aa)
M3XCZ6_FELCAG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (370 aa)
HTR1F5-hydroxytryptamine receptor 1F. (366 aa)
HTR65-hydroxytryptamine receptor 6; Belongs to the G-protein coupled receptor 1 family. (440 aa)
RAP1BRAP1B, member of RAS oncogene family. (187 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
MYL9Myosin light chain 9. (172 aa)
BGNCalcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1485 aa)
CGAGlycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. (152 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
OXTROxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (389 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
GNAI3G protein subunit alpha i3. (354 aa)
SSTSomatostatin. (116 aa)
CNGB3Cyclic nucleotide gated channel subunit beta 3. (807 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2187 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. (770 aa)
LOC101097703EF-hand domain-containing protein; Belongs to the calmodulin family. (86 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1275 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1038 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
CREB5cAMP responsive element binding protein 5. (523 aa)
DRD5Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. (474 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (906 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1011 aa)
PTGER3Prostaglandin E receptor 3. (389 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa)
HHIPHedgehog interacting protein. (682 aa)
PLD1Phospholipase. (1074 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (333 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
GCGGlucagon. (203 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1481 aa)
ADRB1Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity). (474 aa)
PDE10APhosphodiesterase. (1044 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1049 aa)
PIK3R2Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
ENSFCAP00000043586Uncharacterized protein. (261 aa)
GIPRGastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family. (467 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (748 aa)
PTCH1Patched 1. (1451 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1486 aa)
SOX9SRY-box transcription factor 9. (511 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (357 aa)
CNGA3Cyclic nucleotide gated channel subunit alpha 3. (685 aa)
FOSProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
HCAR1Hydroxycarboxylic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (483 aa)
PIK3R3Uncharacterized protein. (461 aa)
HTR45-hydroxytryptamine receptor 4; Belongs to the G-protein coupled receptor 1 family. (469 aa)
BADBCL2 associated agonist of cell death. (273 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (463 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (999 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (255 aa)
PDE4CPhosphodiesterase. (732 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2216 aa)
GNASGNAS complex locus. (968 aa)
NFATC1Nuclear factor of activated T cells 1. (1085 aa)
RYR2Ryanodine receptor 2. (4967 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1135 aa)
CREB3cAMP responsive element binding protein 3. (399 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (1008 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1148 aa)
NPPAAtrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family. (204 aa)
RAC2Rac family small GTPase 2. (234 aa)
AMHAnti-Mullerian hormone. (800 aa)
EDN3Uncharacterized protein. (318 aa)
RPS14Calcium/calmodulin dependent protein kinase II alpha. (566 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (209 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C. (1325 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (901 aa)
AFDNAfadin, adherens junction formation factor. (1873 aa)
LOC101090105Uncharacterized protein. (1608 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1471 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (536 aa)
PDE4DPhosphodiesterase. (809 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1074 aa)
ADCY5Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1329 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
FXYD2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (66 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (544 aa)
PDE4BPhosphodiesterase. (737 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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