STRINGSTRING
CCL2 CCL2 CCL5 CCL5 IL20RB IL20RB CX3CR1 CX3CR1 CCR8 CCR8 CCR4 CCR4 CCL21 CCL21 CCL20 CCL20 CSF1R CSF1R TNFRSF1B TNFRSF1B ACKR4 ACKR4 LTA LTA CXCL8 CXCL8 CCL17 CCL17 IL2RA IL2RA IL22RA1 IL22RA1 IL19 IL19 CCR1 CCR1 TNFRSF1A TNFRSF1A IL2RB IL2RB LTBR LTBR TNFRSF14 TNFRSF14 CCL16 CCL16 CSF1 CSF1 IL6ST IL6ST IL10RA IL10RA ACKR3 ACKR3 IL10 IL10 CCL8 CCL8 IL2 IL2 IL20 IL20 IL24 IL24 CXCL14 CXCL14 CXCL6 CXCL6 CCR2 CCR2 CCL14 CCL14 IL18RAP IL18RAP LOC109493846 LOC109493846 CXCR3 CXCR3 IL20RA IL20RA CCL24 CCL24 CCR3 CCR3 LOC101081599 LOC101081599 CCL13 CCL13 IL6R IL6R CXCR2 CXCR2 TNFSF14 TNFSF14 IL18 IL18 LOC101085650 LOC101085650 CCL1 CCL1 CCL28 CCL28 LOC100302540 LOC100302540 CCL22 CCL22 CCL27 CCL27 IL18R1 IL18R1 CXCL11 CXCL11 CCR7 CCR7 LOC101081091 LOC101081091 LOC100302541 LOC100302541 CCL7 CCL7 CCL26 CCL26 CXCR5 CXCR5 CXCL10 CXCL10 LOC101094096 LOC101094096 CCR10 CCR10 CXCL9 CXCL9 IL2RG IL2RG TNF TNF TNFSF10 TNFSF10 LOC105261012 LOC105261012 CCR5 CCR5 CXCL13 CXCL13 CCR9 CCR9 LOC101094344 LOC101094344 XCR1 XCR1 CXCL12 CXCL12 IL10RB IL10RB CXCR4 CXCR4 CCL19 CCL19 CX3CL1 CX3CL1 CCR6 CCR6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCL2C-C motif chemokine. (99 aa)
CCL5C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa)
IL20RBInterleukin 20 receptor subunit beta. (294 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (399 aa)
CCR8C-C motif chemokine receptor 8; Belongs to the G-protein coupled receptor 1 family. (355 aa)
CCR4C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (360 aa)
CCL21C-C motif chemokine ligand 21. (134 aa)
CCL20C-C motif chemokine. (97 aa)
CSF1RMacrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulat [...] (1213 aa)
TNFRSF1BTNF receptor superfamily member 1B. (463 aa)
ACKR4Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (350 aa)
LTATumor necrosis factor ligand 1E; Belongs to the tumor necrosis factor family. (205 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
CCL17C-C motif chemokine 17; Chemotactic factor for t lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 and CCR8 (By similarity). (99 aa)
IL2RAInterleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (275 aa)
IL22RA1Interleukin 22 receptor subunit alpha 1. (581 aa)
IL19Interleukin 19. (177 aa)
CCR1Chemokine (C-C motif) receptor 1; Belongs to the G-protein coupled receptor 1 family. (360 aa)
TNFRSF1ATNF receptor superfamily member 1A. (444 aa)
IL2RBInterleukin 2 receptor subunit beta. (550 aa)
LTBRLymphotoxin beta receptor. (433 aa)
TNFRSF14TNF receptor superfamily member 14. (476 aa)
CCL16C-C motif chemokine. (107 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (569 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
IL10RAInterleukin 10 receptor subunit alpha. (578 aa)
ACKR3Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (406 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
CCL8C-C motif chemokine. (99 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa)
IL20Interleukin 20. (176 aa)
IL24Interleukin 24. (192 aa)
CXCL14C-X-C motif chemokine ligand 14. (110 aa)
CXCL6C-X-C motif chemokine. (148 aa)
CCR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (328 aa)
CCL14C-C motif chemokine. (95 aa)
IL18RAPInterleukin 18 receptor accessory protein. (586 aa)
LOC109493846Uncharacterized protein. (87 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (368 aa)
IL20RAInterleukin 20 receptor subunit alpha. (712 aa)
CCL24C-C motif chemokine ligand 24. (119 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (361 aa)
LOC101081599SCY domain-containing protein. (158 aa)
CCL13C-C motif chemokine. (98 aa)
IL6RInterleukin 6 receptor. (468 aa)
CXCR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (401 aa)
TNFSF14Tumor necrosis factor ligand 1D; Belongs to the tumor necrosis factor family. (242 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa)
LOC101085650G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa)
CCL1SCY domain-containing protein. (94 aa)
CCL28C-C motif chemokine. (127 aa)
LOC100302540C-C motif chemokine. (93 aa)
CCL22C-C motif chemokine. (93 aa)
CCL27C-C motif chemokine ligand 27. (113 aa)
IL18R1Interleukin 18 receptor 1. (539 aa)
CXCL11C-X-C motif chemokine. (100 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
LOC101081091C-C motif chemokine. (93 aa)
LOC100302541C-C motif chemokine. (102 aa)
CCL7C-C motif chemokine. (99 aa)
CCL26C-C motif chemokine. (94 aa)
CXCR5C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (374 aa)
CXCL10C-X-C motif chemokine. (98 aa)
LOC101094096C-X-C motif chemokine. (104 aa)
CCR10C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family. (363 aa)
CXCL9C-X-C motif chemokine. (155 aa)
IL2RGFibronectin type-III domain-containing protein. (390 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
TNFSF10TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (347 aa)
LOC105261012Uncharacterized protein. (427 aa)
CCR5G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (352 aa)
CXCL13C-X-C motif chemokine. (120 aa)
CCR9C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family. (367 aa)
LOC101094344C-X-C motif chemokine. (113 aa)
XCR1G_PROTEIN_RECEP_F1_2 domain-containing protein. (298 aa)
CXCL12Stromal cell-derived factor 1; Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4 [...] (143 aa)
IL10RBInterleukin 10 receptor subunit beta. (390 aa)
CXCR4C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (400 aa)
CCL19C-C motif chemokine. (115 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (449 aa)
CCR6C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (592 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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