STRINGSTRING
MTOR MTOR PCK1 PCK1 IRS4 IRS4 EEF2 EEF2 PRKAB1 PRKAB1 PDPK1 PDPK1 SREBF1 SREBF1 FBP2 FBP2 PFKFB4 PFKFB4 G6PC3 G6PC3 SLC2A4 SLC2A4 PFKL PFKL STRADA STRADA AKT3 AKT3 PPP2R1A PPP2R1A CCNA1 CCNA1 PFKFB3 PFKFB3 AKT1 AKT1 CPT1C CPT1C G6PC2 G6PC2 HNF4A HNF4A ACACB ACACB FBP1 FBP1 EIF4EBP1 EIF4EBP1 ULK1 ULK1 PIK3R1 PIK3R1 FASN FASN PPP2R5B PPP2R5B GYS2 GYS2 RHEB RHEB STK11 STK11 ADIPOQ ADIPOQ PFKM PFKM CREB3L3 CREB3L3 CAB39L CAB39L RAB11B RAB11B CREB3L1 CREB3L1 IGF1R IGF1R PPP2R3B PPP2R3B MAP3K7 MAP3K7 LIPE LIPE RAB14 RAB14 IRS1 IRS1 CCNA2 CCNA2 PPP2CB PPP2CB LOC101100432 LOC101100432 PPP2R2D PPP2R2D RPS6KB1 RPS6KB1 FOXO3 FOXO3 PIK3CD PIK3CD SCD5 SCD5 ADIPOR2 ADIPOR2 PPP2R3C PPP2R3C PRKAA1 PRKAA1 CAB39 CAB39 STRADB STRADB G6PC G6PC PIK3CB PIK3CB SIRT1 SIRT1 ELAVL1 ELAVL1 ADRA1A ADRA1A PRKAG3 PRKAG3 CPT1B CPT1B PPP2R2B PPP2R2B AKT1S1 AKT1S1 CD36 CD36 INSR INSR ENSFCAP00000031759 ENSFCAP00000031759 CREB5 CREB5 PRKAG1 PRKAG1 LEP LEP TSC2 TSC2 RAB8A RAB8A PRKAA2 PRKAA2 ACACA ACACA PPP2R5D PPP2R5D PRKAB2 PRKAB2 HMGCR HMGCR PIK3CA PIK3CA PPP2CA PPP2CA PPP2R3A PPP2R3A FOXO1 FOXO1 LEPR LEPR MLYCD MLYCD CFTR CFTR RPTOR RPTOR IGF1 IGF1 TSC1 TSC1 PIK3R2 PIK3R2 PFKFB1 PFKFB1 GYS1 GYS1 PIK3R3 PIK3R3 IRS2 IRS2 PCK2 PCK2 PPARG PPARG PPP2R2A PPP2R2A CCND1 CCND1 PPP2R5E PPP2R5E PFKP PFKP EEF2K EEF2K RAB10 RAB10 CPT1A CPT1A PPARGC1A PPARGC1A RPS6KB2 RPS6KB2 CREB3 CREB3 RAB2A RAB2A CAMKK2 CAMKK2 PPP2R1B PPP2R1B TBC1D1 TBC1D1 PPP2R5A PPP2R5A CREB3L2 CREB3L2 AKT2 AKT2 PPP2R2C PPP2R2C
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
IRS4Insulin receptor substrate 4. (1251 aa)
EEF2Eukaryotic translation elongation factor 2. (858 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1147 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (339 aa)
PFKFB46-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4. (469 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (585 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
STRADASTE20 related adaptor alpha. (431 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (606 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (421 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3. (526 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CPT1CCarnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (803 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
ACACBAcetyl-CoA carboxylase beta. (2447 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1113 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
FASNFatty acid synthase. (2655 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (606 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (702 aa)
RHEBRas homolog, mTORC1 binding. (187 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (439 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (283 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (859 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (448 aa)
CAB39LCalcium binding protein 39 like. (193 aa)
RAB11BRAB11B, member RAS oncogene family. (218 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
PPP2R3BProtein phosphatase 2 regulatory subunit B''beta. (579 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
LIPELipase E, hormone sensitive type. (772 aa)
RAB14RAB14, member RAS oncogene family. (215 aa)
IRS1Insulin receptor substrate 1. (1234 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
LOC101100432Uncharacterized protein. (514 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (488 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
FOXO3Forkhead box O3. (672 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
SCD5Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (330 aa)
ADIPOR2Adiponectin receptor 2. (386 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (453 aa)
PRKAA1Non-specific serine/threonine protein kinase. (573 aa)
CAB39Calcium binding protein 39. (373 aa)
STRADBSTE20 related adaptor beta. (415 aa)
G6PCGlucose-6-phosphatase; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity). Belongs to the glucose-6-phosphatase family. (357 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
SIRT1Sirtuin 1. (745 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (326 aa)
ADRA1AAdrenoceptor alpha 1A. (466 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (607 aa)
CPT1BCarnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (583 aa)
AKT1S1AKT1 substrate 1. (276 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
INSRTyrosine-protein kinase receptor. (1381 aa)
ENSFCAP00000031759PFK domain-containing protein. (208 aa)
CREB5cAMP responsive element binding protein 5. (523 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (330 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
TSC2TSC complex subunit 2. (1806 aa)
RAB8ARAB8A, member RAS oncogene family. (216 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
ACACAAcetyl-CoA carboxylase alpha. (2385 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (678 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1150 aa)
FOXO1Forkhead box O1. (662 aa)
LEPRLeptin receptor. (1166 aa)
MLYCDMalonyl-CoA decarboxylase. (496 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1481 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
IGF1Insulin like growth factor 1. (195 aa)
TSC1TSC complex subunit 1. (1110 aa)
PIK3R2Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (476 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (737 aa)
PIK3R3Uncharacterized protein. (461 aa)
IRS2Insulin receptor substrate 2. (1335 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (620 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (312 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
PFKPUncharacterized protein. (753 aa)
EEF2KEukaryotic elongation factor 2 kinase. (725 aa)
RAB10RAB10, member RAS oncogene family. (200 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
PPARGC1APPARG coactivator 1 alpha. (803 aa)
RPS6KB2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (497 aa)
CREB3cAMP responsive element binding protein 3. (399 aa)
RAB2ARAB2A, member RAS oncogene family. (221 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (683 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (772 aa)
TBC1D1TBC1 domain family member 1. (1288 aa)
PPP2R5AProtein phosphatase 2 regulatory subunit B'alpha. (642 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (536 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (488 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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