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| | BAX | BCL2 associated X, apoptosis regulator. (192 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa) |
| | TUBAL3 | Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa) |
| | CTSZ | Cathepsin Z; Belongs to the peptidase C1 family. (362 aa) |
| | LOC101087880 | Uncharacterized protein; Belongs to the peptidase C1 family. (333 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1. (558 aa) |
| | DDIT3 | DNA damage inducible transcript 3. (167 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (467 aa) |
| | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa) |
| | GZMB | Granzyme B; Belongs to the peptidase S1 family. (255 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | LMNB1 | Lamin B1; Belongs to the intermediate filament family. (586 aa) |
| | ERN1 | Endoplasmic reticulum to nucleus signaling 1. (972 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | LOC101090556 | Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa) |
| | DAXX | Death domain associated protein. (748 aa) |
| | ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa) |
| | CASP10 | Caspase 10; Belongs to the peptidase C14A family. (482 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (979 aa) |
| | ENDOG | Endonuclease. (298 aa) |
| | CASP12 | Uncharacterized protein; Belongs to the peptidase C14A family. (527 aa) |
| | NFKBIA | NFKB inhibitor alpha. (314 aa) |
| | ACTG1 | Actin gamma 1. (375 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (444 aa) |
| | PARP2 | Poly [ADP-ribose] polymerase. (567 aa) |
| | HTRA2 | HtrA serine peptidase 2. (458 aa) |
| | CTSF | Cathepsin F; Belongs to the peptidase C1 family. (459 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (989 aa) |
| | CTSD | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (408 aa) |
| | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5. (1366 aa) |
| | CTSC | Cathepsin C; Belongs to the peptidase C1 family. (463 aa) |
| | AIFM1 | Apoptosis inducing factor mitochondria associated 1. (613 aa) |
| | SEPTIN4 | Septin 4. (535 aa) |
| | ATF4 | Activating transcription factor 4. (352 aa) |
| | LOC101099268 | Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (515 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (725 aa) |
| | DFFB | DNA fragmentation factor subunit beta. (647 aa) |
| | LMNA | Lamin A/C; Belongs to the intermediate filament family. (664 aa) |
| | TUBA1C | Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (518 aa) |
| | XIAP | X-linked inhibitor of apoptosis. (454 aa) |
| | EIF2AK3 | Eukaryotic translation initiation factor 2 alpha kinase 3. (1114 aa) |
| | BCL2A1 | BCL2 related protein A1. (174 aa) |
| | GADD45B | Growth arrest and DNA damage inducible beta. (234 aa) |
| | LOC101099215 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (292 aa) |
| | ITPR3 | Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa) |
| | MAP3K14 | Mitogen-activated protein kinase kinase kinase 14. (954 aa) |
| | BIRC3 | Baculoviral IAP repeat containing 3. (624 aa) |
| | MAP2K2 | Protein kinase domain-containing protein. (549 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) |
| | LOC101101202 | Uncharacterized protein; Belongs to the peptidase C1 family. (305 aa) |
| | KRAS | Uncharacterized protein. (380 aa) |
| | CTSO | Cathepsin O; Belongs to the peptidase C1 family. (319 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (451 aa) |
| | PDP | Cathepsin L1; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family. (332 aa) |
| | EIF2S1 | Eukaryotic translation initiation factor 2 subunit alpha. (315 aa) |
| | CSF2RB | Colony stimulating factor 2 receptor beta common subunit. (895 aa) |
| | PARP4 | Poly [ADP-ribose] polymerase. (1700 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (423 aa) |
| | JUN | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | LOC101100947 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity). (350 aa) |
| | LOC105259631 | Uncharacterized protein; Belongs to the peptidase C1 family. (259 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa) |
| | CTSW | Cathepsin W; May have a specific function in the mechanism or regulation of T-cell cytolytic activity; Belongs to the peptidase C1 family. (374 aa) |
| | FAS | Uncharacterized protein. (314 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | DAB2IP | DAB2 interacting protein. (1166 aa) |
| | SPTAN1 | Spectrin alpha, non-erythrocytic 1. (2725 aa) |
| | LOC111559123 | Uncharacterized protein; Belongs to the peptidase C1 family. (323 aa) |
| | CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa) |
| | CASP2 | Caspase 2; Belongs to the peptidase C14A family. (451 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
| | FASLG | Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa) |
| | DIABLO | Uncharacterized protein. (237 aa) |
| | PRF1 | Perforin 1. (555 aa) |
| | PTPN13 | Protein tyrosine phosphatase non-receptor type 13. (2491 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | CTSV | Cathepsin V; Belongs to the peptidase C1 family. (333 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | TUBA4A | Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa) |
| | BIRC5 | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] (142 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | LOC101082891 | Uncharacterized protein; Belongs to the peptidase C1 family. (328 aa) |
| | PARP3 | Poly [ADP-ribose] polymerase. (538 aa) |
| | SPTA1 | Spectrin alpha, erythrocytic 1. (2420 aa) |
| | CAPN1 | Calpain 1; Belongs to the peptidase C2 family. (828 aa) |
| | CFLAR | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (508 aa) |
| | PIK3R2 | Phosphoinositide-3-kinase regulatory subunit 2. (726 aa) |
| | TUBA8 | Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (481 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (760 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (215 aa) |
| | NGF | Nerve growth factor; Belongs to the NGF-beta family. (259 aa) |
| | TRADD | TNFRSF1A associated via death domain. (311 aa) |
| | BBC3 | Uncharacterized protein. (193 aa) |
| | FOS | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa) |
| | PIK3R3 | Uncharacterized protein. (461 aa) |
| | NTRK1 | Tyrosine-protein kinase receptor. (770 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1250 aa) |
| | BAD | BCL2 associated agonist of cell death. (273 aa) |
| | GADD45G | Growth arrest and DNA damage inducible gamma. (159 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (555 aa) |
| | PMAIP1 | Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa) |
| | HRK | Activator of apoptosis harakiri; Promotes apoptosis. (91 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa) |
| | CTSB | Cathepsin B; Belongs to the peptidase C1 family. (339 aa) |
| | TNFSF10 | TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (347 aa) |
| | TRAF1 | TNF receptor-associated factor. (433 aa) |
| | CTSK | Cathepsin S; Belongs to the peptidase C1 family. (445 aa) |
| | LMNB2 | Lamin B2; Belongs to the intermediate filament family. (718 aa) |
| | LOC105261012 | Uncharacterized protein. (427 aa) |
| | CASP6 | Caspase 6; Belongs to the phospholipase A2 family. (431 aa) |
| | PIDD1 | P53-induced death domain protein 1. (940 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (479 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (205 aa) |
| | DFFA | DNA fragmentation factor subunit alpha. (370 aa) |
| | CAPN2 | Calpain 2; Belongs to the peptidase C2 family. (725 aa) |
| | CASP7 | Caspase 7; Belongs to the peptidase C14A family. (409 aa) |
| | BCL2L1 | BCL2 like 1. (271 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase. (571 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (774 aa) |
| | BCL2 | BCL2 apoptosis regulator. (237 aa) |
