(82 nodes) Longevity regulating pathway network (Felis catus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1208 aa)
	BAX	BCL2 associated X, apoptosis regulator. (192 aa)
	IRS4	Insulin receptor substrate 4. (1251 aa)
	PRKAB1	Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
	EHMT1	Euchromatic histone lysine methyltransferase 1. (1312 aa)
	CAMK4	Calcium/calmodulin dependent protein kinase IV. (638 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	EIF4E1B	Eukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (213 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1010 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (989 aa)
	ATF4	Activating transcription factor 4. (352 aa)
	RB1CC1	RB1 inducible coiled-coil 1. (1593 aa)
	EIF4EBP1	Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
	ULK1	Unc-51 like autophagy activating kinase 1. (1113 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
	RHEB	Ras homolog, mTORC1 binding. (187 aa)
	ATG13	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
	STK11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (439 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (283 aa)
	KL	Klotho. (1014 aa)
	CREB3L3	cAMP responsive element binding protein 3 like 3. (448 aa)
	ATF6B	Activating transcription factor 6 beta. (628 aa)
	CREB3L1	cAMP responsive element binding protein 3 like 1. (520 aa)
	KRAS	Uncharacterized protein. (380 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1367 aa)
	IRS1	Insulin receptor substrate 1. (1234 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
	LOC101100432	Uncharacterized protein. (514 aa)
	RPS6KB1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
	FOXO3	Forkhead box O3. (672 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
	ADIPOR2	Adiponectin receptor 2. (386 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (573 aa)
	SOD2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	SIRT1	Sirtuin 1. (745 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
	PRKAG3	Protein kinase AMP-activated non-catalytic subunit gamma 3. (607 aa)
	AKT1S1	AKT1 substrate 1. (276 aa)
	INSR	Tyrosine-protein kinase receptor. (1381 aa)
	CREB5	cAMP responsive element binding protein 5. (523 aa)
	PRKAG1	Protein kinase AMP-activated non-catalytic subunit gamma 1. (330 aa)
	APPL1	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (708 aa)
	TSC2	TSC complex subunit 2. (1806 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (552 aa)
	PRKAB2	Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
	ATG101	Autophagy related 101. (344 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	FOXO1	Forkhead box O1. (662 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
	SESN1	Sestrin 1. (551 aa)
	RPTOR	Regulatory associated protein of MTOR complex 1. (1335 aa)
	IGF1	Insulin like growth factor 1. (195 aa)
	EIF4E	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (237 aa)
	TSC1	TSC complex subunit 1. (1110 aa)
	PIK3R2	Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
	PIK3R3	Uncharacterized protein. (461 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	IRS2	Insulin receptor substrate 2. (1335 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (555 aa)
	EIF4E2	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (358 aa)
	SESN3	Sestrin 3. (492 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (803 aa)
	RPS6KB2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (497 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1135 aa)
	CREB3	cAMP responsive element binding protein 3. (399 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1148 aa)
	SESN2	Sestrin 2. (516 aa)
	CAMKK2	Calcium/calmodulin dependent protein kinase kinase 2. (683 aa)
	CREB3L2	cAMP responsive element binding protein 3 like 2. (536 aa)
	ADCY5	Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1329 aa)
	AKT2	Non-specific serine/threonine protein kinase. (571 aa)
	EHMT2	Euchromatic histone lysine methyltransferase 2. (1407 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSFCAP00000055708	ENSFCAP00000055405	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.617
ADCY1	ADCY3	ENSFCAP00000055708	ENSFCAP00000003366	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.944
ADCY1	ADCY4	ENSFCAP00000055708	ENSFCAP00000005199	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.558
ADCY1	ADCY5	ENSFCAP00000055708	ENSFCAP00000059483	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.538
ADCY1	ADCY6	ENSFCAP00000055708	ENSFCAP00000000072	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.540
ADCY1	ADCY7	ENSFCAP00000055708	ENSFCAP00000028204	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.658
ADCY1	ADCY8	ENSFCAP00000055708	ENSFCAP00000005982	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.958
ADCY1	ADCY9	ENSFCAP00000055708	ENSFCAP00000018672	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.644
ADCY1	AKT1	ENSFCAP00000055708	ENSFCAP00000004586	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.691
ADCY1	AKT2	ENSFCAP00000055708	ENSFCAP00000059662	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase.	0.691
ADCY1	AKT3	ENSFCAP00000055708	ENSFCAP00000003410	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.691
ADCY1	CAMK4	ENSFCAP00000055708	ENSFCAP00000001440	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase IV.	0.674
ADCY1	PRKACA	ENSFCAP00000055708	ENSFCAP00000018754	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.926
ADCY1	PRKACB	ENSFCAP00000055708	ENSFCAP00000040413	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.928
ADCY2	ADCY1	ENSFCAP00000055405	ENSFCAP00000055708	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.617
ADCY2	ADCY4	ENSFCAP00000055405	ENSFCAP00000005199	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.526
ADCY2	ADCY5	ENSFCAP00000055405	ENSFCAP00000059483	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.992
ADCY2	ADCY6	ENSFCAP00000055405	ENSFCAP00000000072	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.800
ADCY2	ADCY7	ENSFCAP00000055405	ENSFCAP00000028204	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.527
ADCY2	ADCY8	ENSFCAP00000055405	ENSFCAP00000005982	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.592