49 items (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PRKCG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	SPHK1	Sphingosine kinase 1. (473 aa)
	MAPKAPK3	MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa)
	LOC101083342	Phospholipase A2. (781 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1514 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
	MAPK11	Mitogen-activated protein kinase. (364 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
	NOS3	Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
	MAPKAPK2	MAPK activated protein kinase 2. (409 aa)
	MAP2K2	Protein kinase domain-containing protein. (549 aa)
	SHC2	SHC adaptor protein 2. (583 aa)
	KRAS	Uncharacterized protein. (380 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (451 aa)
	HSPB1	Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (205 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (604 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	CDC42-2	Uncharacterized protein. (191 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (525 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
	PLA2G4D	Phospholipase A2. (814 aa)
	PLA2G4A	Phospholipase A2. (749 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	MAPK12	Mitogen-activated protein kinase. (367 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
	PTK2	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1112 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
	CNRIP1	Uncharacterized protein. (324 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (521 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	SRC	Tyrosine-protein kinase. (678 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (523 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1318 aa)
	SPHK2	DAGKc domain-containing protein. (660 aa)
	PIK3R2	Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
	NFATC2	Nuclear factor of activated T cells 2. (916 aa)
	PIK3R3	Uncharacterized protein. (461 aa)
	BAD	BCL2 associated agonist of cell death. (273 aa)
	PLA2G4E	Phospholipase A2. (862 aa)
	PLCG1	Phosphoinositide phospholipase C. (1391 aa)
	RAC2	Rac family small GTPase 2. (234 aa)
	AKT2	Non-specific serine/threonine protein kinase. (571 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AKT2	ENSFCAP00000004586	ENSFCAP00000059662	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.901
AKT1	AKT3	ENSFCAP00000004586	ENSFCAP00000003410	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.917
AKT1	BAD	ENSFCAP00000004586	ENSFCAP00000047559	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BCL2 associated agonist of cell death.	0.948
AKT1	CASP9	ENSFCAP00000004586	ENSFCAP00000018153	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Caspase 9; Belongs to the peptidase C14A family.	0.957
AKT1	CDC42-2	ENSFCAP00000004586	ENSFCAP00000024478	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.400
AKT1	HSPB1	ENSFCAP00000004586	ENSFCAP00000018781	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family.	0.425
AKT1	KRAS	ENSFCAP00000004586	ENSFCAP00000016005	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.482
AKT1	MAP2K2	ENSFCAP00000004586	ENSFCAP00000013112	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.411
AKT1	MAPK1	ENSFCAP00000004586	ENSFCAP00000025541	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the PP2C family.	0.928
AKT1	MAPK11	ENSFCAP00000004586	ENSFCAP00000011051	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.933
AKT1	MAPK12	ENSFCAP00000004586	ENSFCAP00000031260	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.930
AKT1	MAPK14	ENSFCAP00000004586	ENSFCAP00000023771	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.933
AKT1	MAPK3	ENSFCAP00000004586	ENSFCAP00000034399	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.929
AKT1	NOS3	ENSFCAP00000004586	ENSFCAP00000012234	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nitric oxide synthase; Produces nitric oxide (NO).	0.950
AKT1	PIK3CA	ENSFCAP00000004586	ENSFCAP00000037527	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.955
AKT1	PIK3CB	ENSFCAP00000004586	ENSFCAP00000027351	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.955
AKT1	PIK3CD	ENSFCAP00000004586	ENSFCAP00000023559	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.951
AKT1	PIK3R1	ENSFCAP00000004586	ENSFCAP00000010244	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase regulatory subunit 1.	0.963
AKT1	PIK3R2	ENSFCAP00000004586	ENSFCAP00000043558	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase regulatory subunit 2.	0.952
AKT1	PIK3R3	ENSFCAP00000004586	ENSFCAP00000046758	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.946