STRINGSTRING
MTOR MTOR ADCY6 ADCY6 AGTR1 AGTR1 NOTCH3 NOTCH3 PRKAB1 PRKAB1 MYLK3 MYLK3 CAMK4 CAMK4 ITPR1 ITPR1 RPS6 RPS6 HRAS HRAS ADCY3 ADCY3 AKT3 AKT3 PIK3R6 PIK3R6 ITPR2 ITPR2 PIK3CG PIK3CG AKT1 AKT1 SPHK1 SPHK1 ADCY4 ADCY4 SERPINE1 SERPINE1 CALML6 CALML6 ADCY8 ADCY8 CALML4 CALML4 GNAI2 GNAI2 GNAI1 GNAI1 ACTA2 ACTA2 GABARAPL2 GABARAPL2 UCP1 UCP1 RRAS2 RRAS2 MEF2B MEF2B SLC9A1 SLC9A1 GNG13 GNG13 GNB3 GNB3 BECN1 BECN1 NOS3 NOS3 ITPR3 ITPR3 MAP2K2 MAP2K2 ADCY10 ADCY10 KRAS KRAS CALM2 CALM2 LIPE LIPE GNB1 GNB1 GNGT1 GNGT1 ADCY9 ADCY9 PRKACA PRKACA PDE3B PDE3B RRAS RRAS MEF2D MEF2D NOS1 NOS1 GNB2 GNB2 GNG14 GNG14 RPS6KB1 RPS6KB1 MAP2K1 MAP2K1 RYR3 RYR3 GABARAP GABARAP GNA13 GNA13 SLC8A2 SLC8A2 PRKAA1 PRKAA1 GNAQ GNAQ PIK3C3 PIK3C3 MAPK1 MAPK1 GNB4 GNB4 GNG11 GNG11 GNGT2 GNGT2 CALML3 CALML3 EGR1 EGR1 GNAI3 GNAI3 ADCY7 ADCY7 PRKAG3 PRKAG3 LOC101097703 LOC101097703 TFAM TFAM SMAD4 SMAD4 RAF1 RAF1 PRKAG1 PRKAG1 GNG3 GNG3 NRAS NRAS PRKAA2 PRKAA2 PLAT PLAT MAPK3 MAPK3 PRKCE PRKCE PRKAB2 PRKAB2 PLCB2 PLCB2 HDAC4 HDAC4 NOS2 NOS2 GNG5 GNG5 SLC8A3 SLC8A3 MRAS MRAS PRKACB PRKACB SLC8A1 SLC8A1 PIK3R4 PIK3R4 PLCB1 PLCB1 SPHK2 SPHK2 APLN APLN ENSFCAP00000043586 ENSFCAP00000043586 NRF1 NRF1 SPP1 SPP1 PLIN1 PLIN1 MYLK4 MYLK4 GNG12 GNG12 TGFBR1 TGFBR1 MYL3 MYL3 GNG8 GNG8 GABARAPL1 GABARAPL1 CDH1 CDH1 KLF2 KLF2 GNG10 GNG10 CCND1 CCND1 CCN2 CCN2 PPARGC1A PPARGC1A RYR2 RYR2 RPS6KB2 RPS6KB2 PLCB4 PLCB4 ADCY2 ADCY2 PLCB3 PLCB3 ADCY1 ADCY1 MYL2 MYL2 MYL4 MYL4 SMAD2 SMAD2 JAG1 JAG1 RYR1 RYR1 LOC101090105 LOC101090105 GNG2 GNG2 ADCY5 ADCY5 GNB5 GNB5 AKT2 AKT2 PIK3R5 PIK3R5 GNG4 GNG4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1208 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (393 aa)
NOTCH3Notch receptor 3. (2323 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
MYLK3Myosin light chain kinase 3. (800 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV. (638 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
RPS6Ribosomal protein S6. (315 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (755 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
SPHK1Sphingosine kinase 1. (473 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1010 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
CALML6Calmodulin like 6. (180 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
CALML4Calmodulin like 4. (196 aa)
GNAI2G protein subunit alpha i2. (436 aa)
GNAI1G protein subunit alpha i1. (354 aa)
ACTA2Actin alpha 2, smooth muscle. (377 aa)
GABARAPL2GABA type A receptor associated protein like 2. (117 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
RRAS2Uncharacterized protein. (204 aa)
MEF2BMyocyte enhancer factor 2B. (375 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (759 aa)
GNG13G protein subunit gamma 13. (67 aa)
GNB3G protein subunit beta 3. (339 aa)
BECN1Beclin 1. (448 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
MAP2K2Protein kinase domain-containing protein. (549 aa)
ADCY10Adenylate cyclase 10. (1608 aa)
KRASUncharacterized protein. (380 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (149 aa)
LIPELipase E, hormone sensitive type. (772 aa)
GNB1G protein subunit beta 1. (340 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
PDE3BPhosphodiesterase. (1122 aa)
RRASRAS related. (218 aa)
MEF2DMyocyte enhancer factor 2D. (519 aa)
NOS1Nitric oxide synthase 1. (1462 aa)
GNB2G protein subunit beta 2. (340 aa)
GNG14Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
RYR3Ryanodine receptor 3. (4859 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
GNA13G protein subunit alpha 13. (377 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
PRKAA1Non-specific serine/threonine protein kinase. (573 aa)
GNAQG protein subunit alpha q. (359 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
GNB4G protein subunit beta 4. (340 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (543 aa)
GNAI3G protein subunit alpha i3. (354 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (607 aa)
LOC101097703EF-hand domain-containing protein; Belongs to the calmodulin family. (86 aa)
TFAMTranscription factor A, mitochondrial. (246 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (330 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (563 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1083 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1165 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
MRASMuscle RAS oncogene homolog. (254 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
SLC8A1Sodium/calcium exchanger 1; Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation- contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels r [...] (973 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
SPHK2DAGKc domain-containing protein. (660 aa)
APLNApelin. (77 aa)
ENSFCAP00000043586Uncharacterized protein. (261 aa)
NRF1Nuclear respiratory factor 1. (556 aa)
SPP1Secreted phosphoprotein 1. (299 aa)
PLIN1Perilipin; Belongs to the perilipin family. (522 aa)
MYLK4Myosin light chain kinase family member 4. (682 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
MYL3Myosin light chain 3. (196 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
GABARAPL1GABA type A receptor associated protein like 1. (151 aa)
CDH1Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (881 aa)
KLF2Kruppel like factor 2. (362 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (312 aa)
CCN2Cellular communication network factor 2. (477 aa)
PPARGC1APPARG coactivator 1 alpha. (803 aa)
RYR2Ryanodine receptor 2. (4967 aa)
RPS6KB2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (497 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1209 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1135 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1245 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1148 aa)
MYL2Myosin light chain 2. (174 aa)
MYL4Myosin light chain 4. (228 aa)
SMAD2Mothers against decapentaplegic homolog. (721 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1287 aa)
RYR1Ryanodine receptor 1. (5041 aa)
LOC101090105Uncharacterized protein. (1608 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (152 aa)
ADCY5Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1329 aa)
GNB5G protein subunit beta 5. (403 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (904 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (250 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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