STRINGSTRING
FLNC FLNC COL9A3 COL9A3 MYLK3 MYLK3 PRKCG PRKCG FLT4 FLT4 PDPK1 PDPK1 MAPK10 MAPK10 ITGA8 ITGA8 HRAS HRAS ITGA2B ITGA2B CTNNB1 CTNNB1 PDGFRB PDGFRB AKT3 AKT3 THBS4 THBS4 PAK1 PAK1 SHC3 SHC3 LAMB1 LAMB1 LAMB4 LAMB4 ITGA3 ITGA3 COL1A1 COL1A1 TNC TNC AKT1 AKT1 VAV1 VAV1 LAMC3 LAMC3 ITGA10 ITGA10 PIP5K1A PIP5K1A PPP1R12C PPP1R12C ITGB7 ITGB7 CRKL CRKL ITGA11 ITGA11 THBS3 THBS3 ACTG1 ACTG1 ITGB8 ITGB8 TLN2 TLN2 PARVG PARVG VASP VASP VEGFC VEGFC DOCK1 DOCK1 VTN VTN LAMA1 LAMA1 PDGFRA PDGFRA FN1 FN1 LAMA3 LAMA3 KDR KDR LAMB2 LAMB2 ITGA5 ITGA5 COL9A1 COL9A1 LAMC2 LAMC2 ITGA4 ITGA4 PIK3R1 PIK3R1 PARVA PARVA PRKCB PRKCB PPP1CC PPP1CC CHAD CHAD THBS1 THBS1 VAV2 VAV2 PRKCA PRKCA XIAP XIAP ITGA2 ITGA2 COL6A3 COL6A3 TLN1 TLN1 BRAF BRAF COL6A6 COL6A6 MYLPF MYLPF ITGA7 ITGA7 COL2A1 COL2A1 BIRC3 BIRC3 TNR TNR COL4A1 COL4A1 COL6A1 COL6A1 ILK ILK SHC2 SHC2 PDGFB PDGFB MYL5 MYL5 PTEN PTEN IGF1R IGF1R PAK2 PAK2 PPP1CA PPP1CA PAK4 PAK4 RHOA RHOA COL1A2 COL1A2 CAV2 CAV2 LAMC1 LAMC1 PPP1R12A PPP1R12A JUN JUN ITGB6 ITGB6 RAP1A RAP1A ARHGAP5 ARHGAP5 MAP2K1 MAP2K1 SOS1 SOS1 PDGFA PDGFA ZYX ZYX PIK3CD PIK3CD GRB2 GRB2 VCL VCL CDC42-2 CDC42-2 SOS2 SOS2 RAP1B RAP1B MAPK1 MAPK1 MYL9 MYL9 LAMB3 LAMB3 COL6A2 COL6A2 ACTN4 ACTN4 PIK3CB PIK3CB FLT1 FLT1 MYL10 MYL10 CAV1 CAV1 SHC4 SHC4 IBSP IBSP PAK6 PAK6 CAV3 CAV3 PAK5 PAK5 ITGA1 ITGA1 THBS2 THBS2 ITGB1 ITGB1 RAF1 RAF1 ITGB3 ITGB3 HGF HGF PTK2 PTK2 ITGB5 ITGB5 MAPK3 MAPK3 FLNB FLNB ITGA6 ITGA6 ROCK1 ROCK1 PIK3CA PIK3CA RAPGEF1 RAPGEF1 PPP1CB PPP1CB MAPK8 MAPK8 CCND3 CCND3 FLNA FLNA MYL12A MYL12A SRC SRC EGFR EGFR VWF VWF IGF1 IGF1 CCND2 CCND2 COL4A3 COL4A3 PIP5K1B PIP5K1B PIK3R2 PIK3R2 GSK3B GSK3B COL4A6 COL4A6 ARHGAP35 ARHGAP35 CRK CRK SPP1 SPP1 PGF PGF MYLK4 MYLK4 VAV3 VAV3 PIK3R3 PIK3R3 COL4A5 COL4A5 BAD BAD PAK3 PAK3 MAPK9 MAPK9 BCAR1 BCAR1 MYL7 MYL7 ITGAV ITGAV CCND1 CCND1 PDGFD PDGFD ACTN1 ACTN1 COL4A2 COL4A2 LAMA2 LAMA2 LAMA4 LAMA4 RASGRF1 RASGRF1 COMP COMP RAC2 RAC2 PARVB PARVB PDGFC PDGFC MYL2 MYL2 CAPN2 CAPN2 RELN RELN ELK1 ELK1 ROCK2 ROCK2 COL9A2 COL9A2 ITGA9 ITGA9 AKT2 AKT2 EGF EGF MET MET DIAPH1 DIAPH1 BCL2 BCL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FLNCFilamin C. (2719 aa)
COL9A3Collagen type IX alpha 3 chain. (681 aa)
MYLK3Myosin light chain kinase 3. (800 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1405 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1062 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1086 aa)
CTNNB1Catenin beta 1. (783 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1131 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
THBS4Thrombospondin 4. (964 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
SHC3SHC adaptor protein 3. (587 aa)
LAMB1Laminin subunit beta 1. (1786 aa)
LAMB4Laminin subunit beta 4. (1747 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1066 aa)
COL1A1Collagen type I alpha 1 chain. (1461 aa)
TNCTenascin C. (2200 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
VAV1Vav guanine nucleotide exchange factor 1. (846 aa)
LAMC3Laminin subunit gamma 3. (1573 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1165 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (550 aa)
PPP1R12CProtein phosphatase 1 regulatory subunit. (773 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (797 aa)
CRKLCRK like proto-oncogene, adaptor protein. (342 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1189 aa)
THBS3Thrombospondin 3. (955 aa)
ACTG1Actin gamma 1. (375 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (767 aa)
TLN2Talin 2. (2542 aa)
PARVGParvin gamma. (187 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (383 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1889 aa)
VTNSMB domain-containing protein. (468 aa)
LAMA1Laminin subunit alpha 1. (3080 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
FN1Fibronectin 1. (2475 aa)
LAMA3Laminin subunit alpha 3. (3332 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1514 aa)
LAMB2Laminin subunit beta 2. (1801 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1104 aa)
COL9A1Collagen type IX alpha 1 chain. (921 aa)
LAMC2Laminin subunit gamma 2. (1191 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1036 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
PARVAParvin alpha. (372 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
CHADChondroadherin. (359 aa)
THBS1Thrombospondin 1. (1170 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
XIAPX-linked inhibitor of apoptosis. (454 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1177 aa)
COL6A3Collagen type VI alpha 3 chain. (3178 aa)
TLN1Talin 1. (2558 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (804 aa)
COL6A6Collagen type VI alpha 6 chain. (2266 aa)
MYLPFMyosin light chain, phosphorylatable, fast skeletal muscle. (170 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1181 aa)
COL2A1Collagen type II alpha 1 chain. (1486 aa)
BIRC3Baculoviral IAP repeat containing 3. (624 aa)
TNRTenascin R. (1358 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
COL6A1Collagen type VI alpha 1 chain. (1027 aa)
ILKIntegrin linked kinase. (451 aa)
SHC2SHC adaptor protein 2. (583 aa)
PDGFBPlatelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (245 aa)
MYL5Myosin light chain 5. (174 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
PAK4Non-specific serine/threonine protein kinase. (592 aa)
RHOARas homolog family member A. (193 aa)
COL1A2Collagen type I alpha 2 chain. (1367 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (262 aa)
LAMC1Laminin subunit gamma 1. (1608 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1029 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
ARHGAP5Rho GTPase activating protein 5. (1503 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
ZYXZyxin. (913 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
VCLVinculin. (1066 aa)
CDC42-2Uncharacterized protein. (191 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
RAP1BRAP1B, member of RAS oncogene family. (187 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
MYL9Myosin light chain 9. (172 aa)
LAMB3Laminin subunit beta 3. (1217 aa)
COL6A2Collagen type VI alpha 2 chain. (1023 aa)
ACTN4Actinin alpha 4. (933 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
MYL10Myosin light chain 10. (167 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
SHC4SHC adaptor protein 4. (630 aa)
IBSPIntegrin binding sialoprotein. (320 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (196 aa)
PAK5Non-specific serine/threonine protein kinase. (725 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1179 aa)
THBS2Thrombospondin 2. (1172 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (801 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
HGFHepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity). (728 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1112 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (800 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
FLNBFilamin B. (2633 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1270 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (333 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
FLNAFilamin A. (2808 aa)
MYL12AMyosin light chain 12A. (178 aa)
SRCTyrosine-protein kinase. (678 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
VWFUncharacterized protein. (2818 aa)
IGF1Insulin like growth factor 1. (195 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
COL4A3Collagen type IV alpha 3 chain. (1669 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (548 aa)
PIK3R2Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
GSK3BProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (433 aa)
COL4A6Collagen type IV alpha 6 chain. (1705 aa)
ARHGAP35Rho GTPase activating protein 35. (1500 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
SPP1Secreted phosphoprotein 1. (299 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
MYLK4Myosin light chain kinase family member 4. (682 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
PIK3R3Uncharacterized protein. (461 aa)
COL4A5Collagen type IV alpha 5 chain. (1689 aa)
BADBCL2 associated agonist of cell death. (273 aa)
PAK3P21 (RAC1) activated kinase 3. (589 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (889 aa)
MYL7Myosin light chain 7. (216 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (312 aa)
PDGFDPlatelet derived growth factor D. (380 aa)
ACTN1Actinin alpha 1. (927 aa)
COL4A2Collagen type IV alpha 2 chain. (1854 aa)
LAMA2Laminin subunit alpha 2. (3125 aa)
LAMA4Laminin subunit alpha 4. (1856 aa)
RASGRF1Ras protein specific guanine nucleotide releasing factor 1. (1312 aa)
COMPCartilage oligomeric matrix protein. (804 aa)
RAC2Rac family small GTPase 2. (234 aa)
PARVBParvin beta. (413 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
MYL2Myosin light chain 2. (174 aa)
CAPN2Calpain 2; Belongs to the peptidase C2 family. (725 aa)
RELNReelin. (3460 aa)
ELK1ETS transcription factor ELK1. (487 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1471 aa)
COL9A2Collagen type IX alpha 2 chain. (722 aa)
ITGA9Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1083 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1213 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1382 aa)
DIAPH1Diaphanous related formin 1. (1290 aa)
BCL2BCL2 apoptosis regulator. (237 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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