STRINGSTRING
ADCY6 ADCY6 TUBAL3 TUBAL3 PRKCG PRKCG ITPR1 ITPR1 HRAS HRAS PDGFRB PDGFRB ADCY3 ADCY3 TUBB4B TUBB4B LOC101090556 LOC101090556 ITPR2 ITPR2 ADCY4 ADCY4 ADCY8 ADCY8 TUBB1 TUBB1 GNAI2 GNAI2 GNAI1 GNAI1 PRKG2 PRKG2 MAPK7 MAPK7 PDGFRA PDGFRA GRM1 GRM1 LOC101099268 LOC101099268 PRKCB PRKCB TUBA1C TUBA1C PRKCA PRKCA ITPR3 ITPR3 MAP2K2 MAP2K2 CDK1 CDK1 PDGFB PDGFB LOC102900772 LOC102900772 KRAS KRAS HTR2B HTR2B M3WS82_FELCA M3WS82_FELCA LPAR1 LPAR1 ADCY9 ADCY9 PRKACA PRKACA MAP2K1 MAP2K1 SOS1 SOS1 TUBB TUBB PDGFA PDGFA GJA1 GJA1 GRB2 GRB2 SOS2 SOS2 GNAQ GNAQ MAPK1 MAPK1 HTR2A HTR2A TJP1 TJP1 GNAI3 GNAI3 ADCY7 ADCY7 PRKG1 PRKG1 TUBB6 TUBB6 HTR2C HTR2C RAF1 RAF1 NRAS NRAS MAPK3 MAPK3 PLCB2 PLCB2 GJD2 GJD2 TUBA4A TUBA4A GUCY1A1 GUCY1A1 PRKACB PRKACB SRC SRC EGFR EGFR PLCB1 PLCB1 ADRB1 ADRB1 GNA11 GNA11 GUCY1B1 GUCY1B1 TUBA8 TUBA8 CSNK1D CSNK1D GRM5 GRM5 DRD1 DRD1 MAP2K5 MAP2K5 GUCY1A2 GUCY1A2 PDGFD PDGFD GNAS GNAS PLCB4 PLCB4 ADCY2 ADCY2 PLCB3 PLCB3 ADCY1 ADCY1 PDGFC PDGFC ADCY5 ADCY5 EGF EGF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1208 aa)
TUBAL3Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1131 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
TUBB4BTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
LOC101090556Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1010 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
TUBB1Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (457 aa)
GNAI2G protein subunit alpha i2. (436 aa)
GNAI1G protein subunit alpha i1. (354 aa)
PRKG2cGMP-dependent protein kinase. (762 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (804 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
GRM1Glutamate metabotropic receptor 1. (1190 aa)
LOC101099268Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (515 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
TUBA1CTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (518 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
MAP2K2Protein kinase domain-containing protein. (549 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
PDGFBPlatelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (245 aa)
LOC102900772Uncharacterized protein. (247 aa)
KRASUncharacterized protein. (380 aa)
HTR2B5-hydroxytryptamine receptor 2B. (503 aa)
M3WS82_FELCAGap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (292 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
TUBBTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
GNAQG protein subunit alpha q. (359 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
HTR2A5-hydroxytryptamine receptor 2A. (470 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (2008 aa)
GNAI3G protein subunit alpha i3. (354 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
TUBB6Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
HTR2C5-hydroxytryptamine receptor 2C. (458 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
GJD2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (321 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
SRCTyrosine-protein kinase. (678 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
ADRB1Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity). (474 aa)
GNA11G protein subunit alpha 11. (359 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (618 aa)
TUBA8Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (481 aa)
CSNK1DCasein kinase 1 delta. (488 aa)
GRM5Glutamate metabotropic receptor 5. (1208 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (463 aa)
MAP2K5Uncharacterized protein; Belongs to the protein kinase superfamily. (448 aa)
GUCY1A2Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (791 aa)
PDGFDPlatelet derived growth factor D. (380 aa)
GNASGNAS complex locus. (968 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1209 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1135 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1245 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1148 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
ADCY5Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1329 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1213 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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