(58 nodes) Antigen processing and presentation network (Felis catus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	CALR	Calreticulin. (417 aa)
	LOC101087880	Uncharacterized protein; Belongs to the peptidase C1 family. (333 aa)
	CD4	CD4 molecule. (487 aa)
	HSPA1L	Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
	RFX5	Regulatory factor X5. (611 aa)
	PSME1	Proteasome activator subunit 1. (249 aa)
	PDIA3	Protein disulfide-isomerase. (505 aa)
	HSPA2	Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (639 aa)
	LGMN	Legumain. (433 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
	LOC101090518	Ig-like domain-containing protein; Belongs to the MHC class II family. (250 aa)
	SLC29A1	Heat shock protein 90 alpha family class B member 1. (740 aa)
	LOC101083591	Uncharacterized protein. (750 aa)
	HSPA5	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (118 aa)
	HSPA4	Heat shock protein family A (Hsp70) member 4. (840 aa)
	LOC101101202	Uncharacterized protein; Belongs to the peptidase C1 family. (305 aa)
	LOC105260551	Ig-like domain-containing protein; Belongs to the MHC class I family. (438 aa)
	PDP	Cathepsin L1; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family. (332 aa)
	LOC105259631	Uncharacterized protein; Belongs to the peptidase C1 family. (259 aa)
	RFXAP	Regulatory factor X associated protein. (234 aa)
	LOC101099296	Ig-like domain-containing protein; Belongs to the MHC class I family. (357 aa)
	CD8B	T-cell surface glycoprotein CD8 beta chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src [...] (219 aa)
	LOC101080790	MHC_I-like_Ag-recog domain-containing protein. (216 aa)
	LOC111559123	Uncharacterized protein; Belongs to the peptidase C1 family. (323 aa)
	SLC26A3-2	Ig-like domain-containing protein; Belongs to the MHC class II family. (254 aa)
	NFYB	Nuclear transcription factor Y subunit beta. (207 aa)
	LOC101089770	Uncharacterized protein. (715 aa)
	CTSV	Cathepsin V; Belongs to the peptidase C1 family. (333 aa)
	HSPA8	Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (667 aa)
	LOC101082653	Ig-like domain-containing protein. (276 aa)
	LOC101082891	Uncharacterized protein; Belongs to the peptidase C1 family. (328 aa)
	CANX	Calnexin. (637 aa)
	LOC101084962	Ig-like domain-containing protein. (253 aa)
	LOC101090265	Ig-like domain-containing protein. (263 aa)
	HSP90AA1	Heat shock protein 90 alpha family class A member 1. (753 aa)
	LOC111556311	Uncharacterized protein. (857 aa)
	LOC111558970	Ig-like domain-containing protein; Belongs to the MHC class II family. (254 aa)
	FLAI-K	Ig-like domain-containing protein; Belongs to the MHC class I family. (406 aa)
	LOC101082906	Ig-like domain-containing protein. (282 aa)
	LOC101090771	Ig-like domain-containing protein; Belongs to the MHC class II family. (257 aa)
	LOC101091023	Ig-like domain-containing protein. (452 aa)
	NFYC	Nuclear transcription factor Y subunit gamma. (439 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
	CTSB	Cathepsin B; Belongs to the peptidase C1 family. (339 aa)
	KLRD1	Killer cell lectin like receptor D1. (186 aa)
	LOC111560444	Ig-like domain-containing protein; Belongs to the MHC class II family. (250 aa)
	PSME3	Uncharacterized protein. (265 aa)
	LOC111556177	Ig-like domain-containing protein; Belongs to the MHC class I family. (499 aa)
	LOC101084108	Ig-like domain-containing protein; Belongs to the MHC class II family. (344 aa)
	ENSFCAP00000052050	C-type lectin domain-containing protein. (231 aa)
	CTSK	Cathepsin S; Belongs to the peptidase C1 family. (445 aa)
	LOC101094232	Ig-like domain-containing protein; Belongs to the MHC class I family. (461 aa)
	TAPBP	Ig-like domain-containing protein. (452 aa)
	LOC111556169	Ig-like domain-containing protein. (276 aa)
	CD8A	T-cell surface glycoprotein CD8 alpha chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Sr [...] (248 aa)
	LOC111559549	Ig-like domain-containing protein. (247 aa)
	LOC111560443	Ig-like domain-containing protein; Belongs to the MHC class II family. (322 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B2M	CALR	ENSFCAP00000011347	ENSFCAP00000000444	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Calreticulin.	0.860
B2M	CD4	ENSFCAP00000011347	ENSFCAP00000003936	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	CD4 molecule.	0.476
B2M	CD8A	ENSFCAP00000011347	ENSFCAP00000059196	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	T-cell surface glycoprotein CD8 alpha chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Sr [...]	0.888
B2M	CD8B	ENSFCAP00000011347	ENSFCAP00000025660	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	T-cell surface glycoprotein CD8 beta chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src [...]	0.605
B2M	FLAI-K	ENSFCAP00000011347	ENSFCAP00000045112	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.998
B2M	KLRD1	ENSFCAP00000011347	ENSFCAP00000051102	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Killer cell lectin like receptor D1.	0.587
B2M	LOC101080790	ENSFCAP00000011347	ENSFCAP00000028198	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	MHC_I-like_Ag-recog domain-containing protein.	0.944
B2M	LOC101082653	ENSFCAP00000011347	ENSFCAP00000038554	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Ig-like domain-containing protein.	0.611
B2M	LOC101082906	ENSFCAP00000011347	ENSFCAP00000045183	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Ig-like domain-containing protein.	0.611
B2M	LOC101083591	ENSFCAP00000011347	ENSFCAP00000009149	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Uncharacterized protein.	0.611
B2M	LOC101084108	ENSFCAP00000011347	ENSFCAP00000051897	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Ig-like domain-containing protein; Belongs to the MHC class II family.	0.549
B2M	LOC101084962	ENSFCAP00000011347	ENSFCAP00000040919	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Ig-like domain-containing protein.	0.611
B2M	LOC101089770	ENSFCAP00000011347	ENSFCAP00000035093	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Uncharacterized protein.	0.573
B2M	LOC101090265	ENSFCAP00000011347	ENSFCAP00000041201	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Ig-like domain-containing protein.	0.610
B2M	LOC101090518	ENSFCAP00000011347	ENSFCAP00000008991	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Ig-like domain-containing protein; Belongs to the MHC class II family.	0.593
B2M	LOC101090771	ENSFCAP00000011347	ENSFCAP00000047011	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Ig-like domain-containing protein; Belongs to the MHC class II family.	0.574
B2M	LOC101091023	ENSFCAP00000011347	ENSFCAP00000048976	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Ig-like domain-containing protein.	0.784
B2M	LOC101094232	ENSFCAP00000011347	ENSFCAP00000054850	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.976
B2M	LOC101099296	ENSFCAP00000011347	ENSFCAP00000025615	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.976
B2M	LOC105260551	ENSFCAP00000011347	ENSFCAP00000015735	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.976