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| | OAS1 | 2'-5'-oligoadenylate synthetase 1. (401 aa) |
| | OAS3 | 2'-5'-oligoadenylate synthetase 3. (1087 aa) |
| | OAS2 | 2'-5'-oligoadenylate synthetase 2. (708 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa) |
| | CCL2 | C-C motif chemokine. (99 aa) |
| | TXN2 | Thioredoxin 2. (163 aa) |
| | CCL5 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa) |
| | STING1 | Stimulator of interferon genes. (377 aa) |
| | JAK1 | Tyrosine-protein kinase. (1157 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (467 aa) |
| | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa) |
| | CYBB | Cytochrome b-245 beta chain. (570 aa) |
| | NFKBIB | NFKB inhibitor beta. (354 aa) |
| | RBCK1 | RANBP2-type and C3HC4-type zinc finger containing 1. (551 aa) |
| | PRKCD | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa) |
| | ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa) |
| | PANX1 | Pannexin; Structural component of the gap junctions and the hemichannels. (427 aa) |
| | IFNB1 | Interferon beta; Has antiviral, antibacterial and anticancer activities. (186 aa) |
| | CXCL8 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa) |
| | RIPK3 | Receptor interacting serine/threonine kinase 3. (509 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa) |
| | CASP12 | Uncharacterized protein; Belongs to the peptidase C14A family. (527 aa) |
| | NLRC4 | NLR family CARD domain containing 4. (1022 aa) |
| | IRF3 | Interferon regulatory factor 3. (420 aa) |
| | CYBA | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa) |
| | NFKBIA | NFKB inhibitor alpha. (314 aa) |
| | TRIP6 | Thyroid hormone receptor interactor 6. (478 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (989 aa) |
| | ANTXR1 | ANTXR cell adhesion molecule 1. (564 aa) |
| | ATG12 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa) |
| | GABARAPL2 | GABA type A receptor associated protein like 2. (117 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1014 aa) |
| | CASR | Calcium sensing receptor. (1081 aa) |
| | TRPV2 | Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (766 aa) |
| | CAMP | Cathelicidin antimicrobial peptide. (171 aa) |
| | TRPM2 | Transient receptor potential cation channel subfamily M member 2. (1500 aa) |
| | TYK2 | Tyrosine-protein kinase. (1181 aa) |
| | SLC29A1 | Heat shock protein 90 alpha family class B member 1. (740 aa) |
| | PSTPIP1 | Proline-serine-threonine phosphatase interacting protein 1. (416 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | ATG16L1 | Autophagy related 16 like 1. (623 aa) |
| | SHARPIN | SHANK associated RH domain interactor. (408 aa) |
| | LOC101082677 | GB1/RHD3-type G domain-containing protein. (693 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (364 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (502 aa) |
| | STAT2 | Signal transducer and activator of transcription. (855 aa) |
| | XIAP | X-linked inhibitor of apoptosis. (454 aa) |
| | P2RX7 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (593 aa) |
| | ITPR3 | Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (718 aa) |
| | BIRC3 | Baculoviral IAP repeat containing 3. (624 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) |
| | NLRP12 | NLR family pyrin domain containing 12. (1034 aa) |
| | IRF9 | Interferon regulatory factor 9. (411 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa) |
| | IFNAR2 | Uncharacterized protein. (519 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | RHOA | Ras homolog family member A. (193 aa) |
| | NLRP6 | NLR family pyrin domain containing 6. (878 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (492 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1977 aa) |
| | LOC101088440 | Uncharacterized protein. (183 aa) |
| | CARD6 | Caspase recruitment domain family member 6. (1028 aa) |
| | PKN2 | Protein kinase N2. (983 aa) |
| | NLRP3 | NLR family pyrin domain containing 3. (1038 aa) |
| | VDAC2 | Voltage dependent anion channel 2. (294 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (423 aa) |
| | JUN | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa) |
| | GABARAP | GABA type A receptor-associated protein. (117 aa) |
| | TAB3 | TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (717 aa) |
| | TXNIP | Thioredoxin interacting protein. (391 aa) |
| | TLR4 | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | IFNAR1 | Interferon alpha and beta receptor subunit 1. (562 aa) |
| | RNASEL | Ribonuclease L. (724 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa) |
| | MFN2 | Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa) |
| | TRAF5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa) |
| | PKN1 | Protein kinase N1. (1064 aa) |
| | CARD8 | Caspase recruitment domain family member 8. (393 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (367 aa) |
| | NAIP | NACHT domain-containing protein. (1436 aa) |
| | MFN1 | Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (804 aa) |
| | LOC101101212 | Uncharacterized protein. (67 aa) |
| | IFNA1 | Interferon alpha; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (194 aa) |
| | TANK | TRAF family member associated NFKB activator. (445 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa) |
| | PLCB2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (308 aa) |
| | NLRX1 | NLR family member X1. (975 aa) |
| | VDAC1 | Voltage dependent anion channel 1. (283 aa) |
| | DHX33 | DEAH-box helicase 33. (699 aa) |
| | NOD1 | Nucleotide binding oligomerization domain containing 1. (953 aa) |
| | GBP1 | Guanylate binding protein 1. (591 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | IFNA13 | Uncharacterized protein. (193 aa) |
| | BRCC3 | BRCA1/BRCA2-containing complex subunit 3. (316 aa) |
| | MAVS | Mitochondrial antiviral signaling protein. (662 aa) |
| | TXN | Thioredoxin; Belongs to the thioredoxin family. (105 aa) |
| | NEK7 | NIMA related kinase 7; Belongs to the protein kinase superfamily. (314 aa) |
| | HSP90AA1 | Heat shock protein 90 alpha family class A member 1. (753 aa) |
| | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa) |
| | NAMPT | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (507 aa) |
| | TICAM1 | Toll like receptor adaptor molecule 1. (815 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (760 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (215 aa) |
| | ERBIN | Erbb2 interacting protein. (1461 aa) |
| | IRF7 | Interferon regulatory factor 7. (512 aa) |
| | ATG5 | Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (555 aa) |
| | YWHAE | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa) |
| | GABARAPL1 | GABA type A receptor associated protein like 1. (151 aa) |
| | GPRC6A | G protein-coupled receptor class C group 6 member A. (928 aa) |
| | STAT1 | Signal transducer and activator of transcription. (885 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa) |
| | CTSB | Cathepsin B; Belongs to the peptidase C1 family. (339 aa) |
| | MCU | Mitochondrial calcium uniporter. (475 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | ANTXR2 | Anthrax toxin receptor; Belongs to the ATR family. (490 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (479 aa) |
| | ANTXRL | VWFA domain-containing protein. (573 aa) |
| | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1209 aa) |
| | PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1245 aa) |
| | VDAC3 | Voltage dependent anion channel 3. (315 aa) |
| | TRPM7 | Transient receptor potential cation channel subfamily M member 7. (1867 aa) |
| | NLRP7 | Uncharacterized protein. (185 aa) |
| | TNFAIP3 | TNF alpha induced protein 3. (804 aa) |
| | LOC102900063 | VWFA domain-containing protein. (566 aa) |
| | RNF31 | Uncharacterized protein. (1081 aa) |
| | BCL2L1 | BCL2 like 1. (271 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (774 aa) |
| | IFI16 | Uncharacterized protein. (684 aa) |
| | BCL2 | BCL2 apoptosis regulator. (237 aa) |
