STRINGSTRING
MTOR MTOR IL23R IL23R JAK1 JAK1 STAT5B STAT5B STAT3 STAT3 MAPK10 MAPK10 NFKBIB NFKBIB HIF1A HIF1A CD4 CD4 AHR AHR TGFB1 TGFB1 IL2RA IL2RA IL1B IL1B IL21 IL21 NFKBIA NFKBIA RUNX1 RUNX1 JAK3 JAK3 NFKB1 NFKB1 IL2RB IL2RB IL17F IL17F IFNG IFNG TYK2 TYK2 LOC101090518 LOC101090518 SLC29A1 SLC29A1 IL21R IL21R ZAP70 ZAP70 TBX21 TBX21 RXRG RXRG IL6ST IL6ST CD3D CD3D MAPK11 MAPK11 IL23A IL23A IL1R1 IL1R1 IL2 IL2 STAT6 STAT6 IL22 IL22 IL1RAP IL1RAP IKBKG IKBKG JUN JUN NFATC3 NFATC3 IL6R IL6R IFNGR1 IFNGR1 MAPK14 MAPK14 IRF4 IRF4 PPP3CB PPP3CB MAPK1 MAPK1 MAPK12 MAPK12 SMAD4 SMAD4 IL17D IL17D IL17A IL17A SLC26A3-2 SLC26A3-2 MAPK3 MAPK3 RARA RARA CNRIP1 CNRIP1 PPP3CA PPP3CA LOC101082653 LOC101082653 MAPK8 MAPK8 LCK LCK IFNGR2 IFNGR2 RORA RORA IL4R IL4R LOC101084962 LOC101084962 PRKCQ PRKCQ LOC101090265 LOC101090265 HSP90AA1 HSP90AA1 PPP3CC PPP3CC LOC101085801 LOC101085801 GATA3 GATA3 IKBKB IKBKB LOC111558970 LOC111558970 LOC101082906 LOC101082906 NFATC2 NFATC2 FOS FOS LOC101090771 LOC101090771 MAPK9 MAPK9 TGFBR1 TGFBR1 RELA RELA NFKBIE NFKBIE RXRA RXRA IL2RG IL2RG JAK2 JAK2 STAT1 STAT1 LOC111560444 LOC111560444 LOC101084108 LOC101084108 NFATC1 NFATC1 PLCG1 PLCG1 STAT5A STAT5A RORC RORC SMAD2 SMAD2 LOC111556169 LOC111556169 LOC111559549 LOC111559549 LOC111560443 LOC111560443 CHUK CHUK LOC101080774 LOC101080774 CD247 CD247 IL12RB1 IL12RB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa)
IL23RInterleukin 23 receptor. (631 aa)
JAK1Tyrosine-protein kinase. (1157 aa)
STAT5BSignal transducer and activator of transcription. (786 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
NFKBIBNFKB inhibitor beta. (354 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (825 aa)
CD4CD4 molecule. (487 aa)
AHRUncharacterized protein. (849 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
IL2RAInterleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (275 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (161 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (493 aa)
JAK3Tyrosine-protein kinase. (1232 aa)
NFKB1Nuclear factor kappa B subunit 1. (989 aa)
IL2RBInterleukin 2 receptor subunit beta. (550 aa)
IL17FInterleukin 17F. (157 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
TYK2Tyrosine-protein kinase. (1181 aa)
LOC101090518Ig-like domain-containing protein; Belongs to the MHC class II family. (250 aa)
SLC29A1Heat shock protein 90 alpha family class B member 1. (740 aa)
IL21RInterleukin 21 receptor. (538 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
TBX21T-box transcription factor 21. (535 aa)
RXRGRetinoid X receptor gamma. (463 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
CD3DCD3d molecule. (170 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
IL23AInterleukin 23 subunit alpha. (196 aa)
IL1R1Interleukin 1 receptor type 1. (572 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa)
STAT6Signal transducer and activator of transcription. (844 aa)
IL22Interleukin 22. (179 aa)
IL1RAPInterleukin 1 receptor accessory protein. (639 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (423 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
IL6RInterleukin 6 receptor. (468 aa)
IFNGR1Interferon gamma receptor 1. (469 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
IRF4Interferon regulatory factor 4. (451 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
IL17DInterleukin 17D. (202 aa)
IL17AInterleukin 17A. (155 aa)
SLC26A3-2Ig-like domain-containing protein; Belongs to the MHC class II family. (254 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
RARARetinoic acid receptor alpha. (462 aa)
CNRIP1Uncharacterized protein. (324 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
LOC101082653Ig-like domain-containing protein. (276 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
LCKTyrosine-protein kinase. (520 aa)
IFNGR2Interferon gamma receptor 2. (390 aa)
RORARAR related orphan receptor A. (523 aa)
IL4RInterleukin 4 receptor. (818 aa)
LOC101084962Ig-like domain-containing protein. (253 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
LOC101090265Ig-like domain-containing protein. (263 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (753 aa)
PPP3CCSerine/threonine-protein phosphatase. (523 aa)
LOC101085801Uncharacterized protein. (467 aa)
GATA3GATA binding protein 3. (444 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (760 aa)
LOC111558970Ig-like domain-containing protein; Belongs to the MHC class II family. (254 aa)
LOC101082906Ig-like domain-containing protein. (282 aa)
NFATC2Nuclear factor of activated T cells 2. (916 aa)
FOSProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa)
LOC101090771Ig-like domain-containing protein; Belongs to the MHC class II family. (257 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
NFKBIENFKB inhibitor epsilon. (362 aa)
RXRARetinoid X receptor alpha. (654 aa)
IL2RGFibronectin type-III domain-containing protein. (390 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
STAT1Signal transducer and activator of transcription. (885 aa)
LOC111560444Ig-like domain-containing protein; Belongs to the MHC class II family. (250 aa)
LOC101084108Ig-like domain-containing protein; Belongs to the MHC class II family. (344 aa)
NFATC1Nuclear factor of activated T cells 1. (1085 aa)
PLCG1Phosphoinositide phospholipase C. (1391 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
RORCRAR related orphan receptor C. (518 aa)
SMAD2Mothers against decapentaplegic homolog. (721 aa)
LOC111556169Ig-like domain-containing protein. (276 aa)
LOC111559549Ig-like domain-containing protein. (247 aa)
LOC111560443Ig-like domain-containing protein; Belongs to the MHC class II family. (322 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (774 aa)
LOC101080774IRF tryptophan pentad repeat domain-containing protein. (467 aa)
CD247CD247 molecule. (250 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (673 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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