STRINGSTRING
PDPK1 PDPK1 NCK2 NCK2 MAPK10 MAPK10 HRAS HRAS NFKBIB NFKBIB AKT3 AKT3 CSF2 CSF2 PAK1 PAK1 CD4 CD4 PTPN6 PTPN6 MAP3K8 MAP3K8 AKT1 AKT1 VAV1 VAV1 NFKBIA NFKBIA NFKB1 NFKB1 IFNG IFNG ITK ITK ZAP70 ZAP70 PIK3R1 PIK3R1 VAV2 VAV2 CD3D CD3D MAPK11 MAPK11 GRAP2 GRAP2 IL10 IL10 IL2 IL2 MAP3K14 MAP3K14 MALT1 MALT1 MAP2K2 MAP2K2 CD28 CD28 KRAS KRAS PAK2 PAK2 MAP3K7 MAP3K7 PAK4 PAK4 RHOA RHOA CDK4 CDK4 IKBKG IKBKG JUN JUN MAP2K1 MAP2K1 SOS1 SOS1 NFATC3 NFATC3 PIK3CD PIK3CD GRB2 GRB2 MAPK14 MAPK14 CDC42-2 CDC42-2 SOS2 SOS2 PPP3CB PPP3CB MAPK1 MAPK1 CD8B CD8B CBLB CBLB PIK3CB PIK3CB PAK6 PAK6 PAK5 PAK5 MAPK12 MAPK12 RAF1 RAF1 CD40LG CD40LG NRAS NRAS MAPK3 MAPK3 CARD11 CARD11 CNRIP1 CNRIP1 PPP3CA PPP3CA PIK3CA PIK3CA TEC TEC MAPK8 MAPK8 LCK LCK PRKCQ PRKCQ CTLA4 CTLA4 PPP3CC PPP3CC LCP2 LCP2 PIK3R2 PIK3R2 GSK3B GSK3B IKBKB IKBKB NFATC2 NFATC2 PDCD1 PDCD1 FOS FOS VAV3 VAV3 MAP2K7 MAP2K7 PIK3R3 PIK3R3 PAK3 PAK3 MAPK9 MAPK9 RELA RELA NFKBIE NFKBIE BCL10 BCL10 DLG1 DLG1 TNF TNF NFATC1 NFATC1 PLCG1 PLCG1 RASGRP1 RASGRP1 IL5 IL5 CD8A CD8A LOC111559549 LOC111559549 AKT2 AKT2 ICOS ICOS CHUK CHUK CD247 CD247
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
NCK2Cytoplasmic protein. (380 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
NFKBIBNFKB inhibitor beta. (354 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CSF2Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (142 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
CD4CD4 molecule. (487 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (615 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
VAV1Vav guanine nucleotide exchange factor 1. (846 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
NFKB1Nuclear factor kappa B subunit 1. (989 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
ITKTyrosine-protein kinase. (620 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
CD3DCD3d molecule. (170 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
GRAP2GRB2 related adaptor protein 2. (322 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (954 aa)
MALT1MALT1 paracaspase. (848 aa)
MAP2K2Protein kinase domain-containing protein. (549 aa)
CD28T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. (255 aa)
KRASUncharacterized protein. (380 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
PAK4Non-specific serine/threonine protein kinase. (592 aa)
RHOARas homolog family member A. (193 aa)
CDK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (423 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CDC42-2Uncharacterized protein. (191 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
CD8BT-cell surface glycoprotein CD8 beta chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src [...] (219 aa)
CBLBCbl proto-oncogene B. (1182 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
PAK5Non-specific serine/threonine protein kinase. (725 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
CD40LGCD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (260 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CARD11Caspase recruitment domain family member 11. (1163 aa)
CNRIP1Uncharacterized protein. (324 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TECTyrosine-protein kinase. (650 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
LCKTyrosine-protein kinase. (520 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (268 aa)
PPP3CCSerine/threonine-protein phosphatase. (523 aa)
LCP2Lymphocyte cytosolic protein 2. (534 aa)
PIK3R2Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
GSK3BProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (433 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (760 aa)
NFATC2Nuclear factor of activated T cells 2. (916 aa)
PDCD1Programmed cell death 1. (278 aa)
FOSProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
PIK3R3Uncharacterized protein. (461 aa)
PAK3P21 (RAC1) activated kinase 3. (589 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
NFKBIENFKB inhibitor epsilon. (362 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (939 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
NFATC1Nuclear factor of activated T cells 1. (1085 aa)
PLCG1Phosphoinositide phospholipase C. (1391 aa)
RASGRP1RAS guanyl releasing protein 1. (877 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
CD8AT-cell surface glycoprotein CD8 alpha chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Sr [...] (248 aa)
LOC111559549Ig-like domain-containing protein. (247 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
ICOSInducible T cell costimulator. (247 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (774 aa)
CD247CD247 molecule. (250 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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