(65 nodes) B cell receptor signaling pathway network (Felis catus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	CD19	CD19 molecule. (641 aa)
	NFKBIB	NFKB inhibitor beta. (354 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (615 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	VAV1	Vav guanine nucleotide exchange factor 1. (846 aa)
	INPPL1	Inositol polyphosphate phosphatase like 1. (1264 aa)
	NFKBIA	NFKB inhibitor alpha. (314 aa)
	CD81	Tetraspanin. (236 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (989 aa)
	CD79A	CD79a molecule. (236 aa)
	RASGRP3	RAS guanyl releasing protein 3. (692 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
	INPP5D	Inositol polyphosphate-5-phosphatase D. (1181 aa)
	VAV2	Vav guanine nucleotide exchange factor 2. (878 aa)
	MALT1	MALT1 paracaspase. (848 aa)
	MAP2K2	Protein kinase domain-containing protein. (549 aa)
	SYK	Spleen associated tyrosine kinase. (636 aa)
	KRAS	Uncharacterized protein. (380 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (423 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	LYN	Tyrosine-protein kinase. (526 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
	NFATC3	Nuclear factor of activated T cells 3. (1075 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	DAPP1	Dual adaptor of phosphotyrosine and 3-phosphoinositides 1. (351 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
	CD72	CD72 molecule. (371 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (525 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	LOC101086846	Uncharacterized protein. (125 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
	CARD11	Caspase recruitment domain family member 11. (1163 aa)
	CNRIP1	Uncharacterized protein. (324 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (521 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	BLNK	B cell linker. (479 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (523 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1318 aa)
	BTK	Tyrosine-protein kinase. (692 aa)
	PIK3R2	Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
	GSK3B	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (433 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (760 aa)
	NFATC2	Nuclear factor of activated T cells 2. (916 aa)
	FOS	Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa)
	CD22	CD22 molecule. (845 aa)
	VAV3	Vav guanine nucleotide exchange factor 3. (875 aa)
	PIK3R3	Uncharacterized protein. (461 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (555 aa)
	NFKBIE	NFKB inhibitor epsilon. (362 aa)
	BCL10	BCL10 immune signaling adaptor. (233 aa)
	NFATC1	Nuclear factor of activated T cells 1. (1085 aa)
	CR2	Complement C3d receptor 2. (1474 aa)
	RAC2	Rac family small GTPase 2. (234 aa)
	AKT2	Non-specific serine/threonine protein kinase. (571 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (774 aa)
	PIK3AP1	Phosphoinositide-3-kinase adaptor protein 1. (843 aa)
	CD79B	CD79b molecule. (266 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AKT2	ENSFCAP00000004586	ENSFCAP00000059662	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.901
AKT1	AKT3	ENSFCAP00000004586	ENSFCAP00000003410	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.917
AKT1	CHUK	ENSFCAP00000004586	ENSFCAP00000060797	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.969
AKT1	DAPP1	ENSFCAP00000004586	ENSFCAP00000024043	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Dual adaptor of phosphotyrosine and 3-phosphoinositides 1.	0.453
AKT1	GRB2	ENSFCAP00000004586	ENSFCAP00000023767	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Growth factor receptor bound protein 2.	0.437
AKT1	GSK3B	ENSFCAP00000004586	ENSFCAP00000043679	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.952
AKT1	IKBKB	ENSFCAP00000004586	ENSFCAP00000044529	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.961
AKT1	IKBKG	ENSFCAP00000004586	ENSFCAP00000020981	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.929
AKT1	JUN	ENSFCAP00000004586	ENSFCAP00000021043	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.926
AKT1	KRAS	ENSFCAP00000004586	ENSFCAP00000016005	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.482
AKT1	LYN	ENSFCAP00000004586	ENSFCAP00000022129	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase.	0.444
AKT1	MAP2K2	ENSFCAP00000004586	ENSFCAP00000013112	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.411
AKT1	MAPK1	ENSFCAP00000004586	ENSFCAP00000025541	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the PP2C family.	0.928
AKT1	MAPK3	ENSFCAP00000004586	ENSFCAP00000034399	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.929
AKT1	PIK3CA	ENSFCAP00000004586	ENSFCAP00000037527	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.955
AKT1	PIK3CB	ENSFCAP00000004586	ENSFCAP00000027351	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.955
AKT1	PIK3CD	ENSFCAP00000004586	ENSFCAP00000023559	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.951
AKT1	PIK3R1	ENSFCAP00000004586	ENSFCAP00000010244	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase regulatory subunit 1.	0.963
AKT1	PIK3R2	ENSFCAP00000004586	ENSFCAP00000043558	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase regulatory subunit 2.	0.952
AKT1	PIK3R3	ENSFCAP00000004586	ENSFCAP00000046758	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.946