STRINGSTRING
PDPK1 PDPK1 MAPK10 MAPK10 HRAS HRAS AKT3 AKT3 CSF2 CSF2 AKT1 AKT1 VAV1 VAV1 LOC101083342 LOC101083342 GAB2 GAB2 PIK3R1 PIK3R1 INPP5D INPP5D VAV2 VAV2 MAPK11 MAPK11 MAP2K4 MAP2K4 PRKCA PRKCA ALOX5 ALOX5 MAP2K2 MAP2K2 SYK SYK FCER1A FCER1A MAP2K6 MAP2K6 KRAS KRAS MAP2K1 MAP2K1 LYN LYN SOS1 SOS1 PIK3CD PIK3CD GRB2 GRB2 MAPK14 MAPK14 SOS2 SOS2 MAPK1 MAPK1 PLA2G4D PLA2G4D PLA2G4A PLA2G4A PIK3CB PIK3CB ALOX5AP ALOX5AP MAPK12 MAPK12 RAF1 RAF1 NRAS NRAS MAPK3 MAPK3 IL13 IL13 PIK3CA PIK3CA FCER1G FCER1G MAPK8 MAPK8 PLCG2 PLCG2 BTK BTK LCP2 LCP2 PIK3R2 PIK3R2 VAV3 VAV3 MAP2K7 MAP2K7 PIK3R3 PIK3R3 MAPK9 MAPK9 TNF TNF LOC101101505 LOC101101505 PLA2G4E PLA2G4E PLCG1 PLCG1 LOC102902042 LOC102902042 RAC2 RAC2 IL5 IL5 LOC102902259-2 LOC102902259-2 AKT2 AKT2 MAP2K3 MAP2K3 LOC102902189 LOC102902189
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CSF2Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (142 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
VAV1Vav guanine nucleotide exchange factor 1. (846 aa)
LOC101083342Phospholipase A2. (781 aa)
GAB2GRB2 associated binding protein 2. (678 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1181 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (411 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
ALOX5Arachidonate 5-lipoxygenase. (745 aa)
MAP2K2Protein kinase domain-containing protein. (549 aa)
SYKSpleen associated tyrosine kinase. (636 aa)
FCER1AFc fragment of IgE receptor Ia. (263 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
KRASUncharacterized protein. (380 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
LYNTyrosine-protein kinase. (526 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
PLA2G4DPhospholipase A2. (814 aa)
PLA2G4APhospholipase A2. (749 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
ALOX5APArachidonate 5-lipoxygenase activating protein. (161 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
IL13Interleukin 13. (144 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FCER1GFc fragment of IgE receptor Ig. (86 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1318 aa)
BTKTyrosine-protein kinase. (692 aa)
LCP2Lymphocyte cytosolic protein 2. (534 aa)
PIK3R2Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
PIK3R3Uncharacterized protein. (461 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
LOC101101505Uncharacterized protein. (259 aa)
PLA2G4EPhospholipase A2. (862 aa)
PLCG1Phosphoinositide phospholipase C. (1391 aa)
LOC102902042Uncharacterized protein. (243 aa)
RAC2Rac family small GTPase 2. (234 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
LOC102902259-2Uncharacterized protein. (238 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (383 aa)
LOC102902189Uncharacterized protein. (236 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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