STRINGSTRING
BAX BAX NTF4 NTF4 CAMK4 CAMK4 RPS6KA5 RPS6KA5 PDPK1 PDPK1 MAPK10 MAPK10 HRAS HRAS SH2B3 SH2B3 NFKBIB NFKBIB AKT3 AKT3 PRKCD PRKCD SHC3 SHC3 AKT1 AKT1 ABL1 ABL1 CRKL CRKL CALML6 CALML6 CALML4 CALML4 NFKBIA NFKBIA NTF3 NTF3 NFKB1 NFKB1 MAP3K5 MAP3K5 MAPK7 MAPK7 NTRK2 NTRK2 RPS6KA6 RPS6KA6 ATF4 ATF4 IRAK1 IRAK1 PIK3R1 PIK3R1 IRAK2 IRAK2 TP73 TP73 MAPK11 MAPK11 BRAF BRAF MAPKAPK2 MAPKAPK2 MAP3K1 MAP3K1 MAP2K2 MAP2K2 NTRK3 NTRK3 SORT1 SORT1 SHC2 SHC2 KRAS KRAS RIPK2 RIPK2 CALM2 CALM2 RHOA RHOA IRS1 IRS1 IRAK4 IRAK4 MATK MATK JUN JUN RAP1A RAP1A MAP2K1 MAP2K1 ZNF274 ZNF274 SOS1 SOS1 FOXO3 FOXO3 PIK3CD PIK3CD GRB2 GRB2 MAPK14 MAPK14 CDC42-2 CDC42-2 SOS2 SOS2 RAP1B RAP1B SH2B2 SH2B2 MAPK1 MAPK1 PIK3CB PIK3CB CALML3 CALML3 MAP3K3 MAP3K3 LOC101097703 LOC101097703 RPS6KA3 RPS6KA3 SHC4 SHC4 PTPN11 PTPN11 ARHGDIA ARHGDIA MAPK12 MAPK12 RAF1 RAF1 FASLG FASLG ARHGDIB ARHGDIB NRAS NRAS MAPK3 MAPK3 MAGED1 MAGED1 RPS6KA1 RPS6KA1 PIK3CA PIK3CA RAPGEF1 RAPGEF1 MAPK8 MAPK8 FRS2 FRS2 SH2B1 SH2B1 PLCG2 PLCG2 RPS6KA2 RPS6KA2 PIK3R2 PIK3R2 ENSFCAP00000043586 ENSFCAP00000043586 GSK3B GSK3B NGFR NGFR PSEN2 PSEN2 IKBKB IKBKB CAMK2B CAMK2B CRK CRK NGF NGF MAP2K7 MAP2K7 PIK3R3 PIK3R3 NTRK1 NTRK1 BAD BAD MAPK9 MAPK9 TRAF6 TRAF6 PSEN1 PSEN1 RELA RELA YWHAE YWHAE NFKBIE NFKBIE BDNF BDNF MAP2K5 MAP2K5 PRDM4 PRDM4 PLCG1 PLCG1 RPS14 RPS14 ARHGDIG ARHGDIG AKT2 AKT2 CAMK2D CAMK2D IRAK3 IRAK3 KIDINS220 KIDINS220 BCL2 BCL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BAXBCL2 associated X, apoptosis regulator. (192 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (210 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV. (638 aa)
RPS6KA5Ribosomal protein S6 kinase. (798 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
SH2B3SH2B adaptor protein 3. (578 aa)
NFKBIBNFKB inhibitor beta. (354 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
SHC3SHC adaptor protein 3. (587 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ABL1Tyrosine-protein kinase. (1150 aa)
CRKLCRK like proto-oncogene, adaptor protein. (342 aa)
CALML6Calmodulin like 6. (180 aa)
CALML4Calmodulin like 4. (196 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
NFKB1Nuclear factor kappa B subunit 1. (989 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1366 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (804 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
RPS6KA6Ribosomal protein S6 kinase. (744 aa)
ATF4Activating transcription factor 4. (352 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (724 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (618 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (749 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (804 aa)
MAPKAPK2MAPK activated protein kinase 2. (409 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1509 aa)
MAP2K2Protein kinase domain-containing protein. (549 aa)
NTRK3Tyrosine-protein kinase receptor. (863 aa)
SORT1Sortilin. (877 aa)
SHC2SHC adaptor protein 2. (583 aa)
KRASUncharacterized protein. (380 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (149 aa)
RHOARas homolog family member A. (193 aa)
IRS1Insulin receptor substrate 1. (1234 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (492 aa)
MATKTyrosine-protein kinase. (838 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ZNF274Zinc finger protein 274. (622 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
FOXO3Forkhead box O3. (672 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CDC42-2Uncharacterized protein. (191 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
RAP1BRAP1B, member of RAS oncogene family. (187 aa)
SH2B2SH2B adaptor protein 2. (679 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
MAP3K3Uncharacterized protein. (626 aa)
LOC101097703EF-hand domain-containing protein; Belongs to the calmodulin family. (86 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
SHC4SHC adaptor protein 4. (630 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
ARHGDIAUncharacterized protein. (425 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
FASLGTumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa)
ARHGDIBRho GDP dissociation inhibitor beta. (200 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
MAGED1MAGE domain-containing protein. (793 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1270 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
FRS2Fibroblast growth factor receptor substrate 2. (543 aa)
SH2B1SH2B adaptor protein 1. (757 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1318 aa)
RPS6KA2Ribosomal protein S6 kinase. (741 aa)
PIK3R2Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
ENSFCAP00000043586Uncharacterized protein. (261 aa)
GSK3BProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (433 aa)
NGFRNerve growth factor receptor. (421 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (562 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (760 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (748 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (259 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
PIK3R3Uncharacterized protein. (461 aa)
NTRK1Tyrosine-protein kinase receptor. (770 aa)
BADBCL2 associated agonist of cell death. (273 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (455 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
NFKBIENFKB inhibitor epsilon. (362 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (255 aa)
MAP2K5Uncharacterized protein; Belongs to the protein kinase superfamily. (448 aa)
PRDM4PR/SET domain 4. (846 aa)
PLCG1Phosphoinositide phospholipase C. (1391 aa)
RPS14Calcium/calmodulin dependent protein kinase II alpha. (566 aa)
ARHGDIGRho GDP dissociation inhibitor gamma. (252 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (544 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (551 aa)
KIDINS220Kinase D interacting substrate 220. (1694 aa)
BCL2BCL2 apoptosis regulator. (237 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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