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ALOX12 ALOX12 APP APP PRKCG PRKCG ITPR1 ITPR1 HRAS HRAS CACNA1F CACNA1F ITPR2 ITPR2 CACNA1S CACNA1S SLC6A4 SLC6A4 TPH2 TPH2 GNAI2 GNAI2 GABRB1 GABRB1 CYP4X1 CYP4X1 GNAI1 GNAI1 LOC101083342 LOC101083342 HTR1B HTR1B LOC101089387 LOC101089387 KCND2 KCND2 GNG13 GNG13 LOC101084129 LOC101084129 PRKCB PRKCB HTR1D HTR1D SLC18A1 SLC18A1 PRKCA PRKCA GNB3 GNB3 BRAF BRAF SLC18A2 SLC18A2 MAOB MAOB ALOX5 ALOX5 ITPR3 ITPR3 HTR1A HTR1A ALOX12B ALOX12B LOC102900772 LOC102900772 KRAS KRAS HTR2B HTR2B GNB1 GNB1 GNGT1 GNGT1 PRKACA PRKACA TRPC1 TRPC1 PTGS2 PTGS2 TPH1 TPH1 GNB2 GNB2 GNG14 GNG14 MAP2K1 MAP2K1 KCNN2 KCNN2 GNAQ GNAQ HTR1F HTR1F HTR6 HTR6 KCNJ3 KCNJ3 MAPK1 MAPK1 HTR2A HTR2A PLA2G4D PLA2G4D GNB4 GNB4 GNG11 GNG11 GNGT2 GNGT2 PLA2G4A PLA2G4A GNAI3 GNAI3 CACNA1C CACNA1C LOC101090040 LOC101090040 KCNJ5 KCNJ5 HTR2C HTR2C CASP3 CASP3 KCNJ9 KCNJ9 RAF1 RAF1 GNG3 GNG3 NRAS NRAS MAPK3 MAPK3 PLCB2 PLCB2 RAPGEF3 RAPGEF3 GNG5 GNG5 PRKACB PRKACB CACNA1A CACNA1A PLCB1 PLCB1 HTR7 HTR7 ARAF ARAF HTR4 HTR4 MAOA MAOA GNG12 GNG12 GNG8 GNG8 DDC DDC HTR5A HTR5A GABRB3 GABRB3 GNG10 GNG10 CACNA1D CACNA1D ALOX15B ALOX15B GNAS GNAS CACNA1B CACNA1B PLA2G4E PLA2G4E DUSP1 DUSP1 PLCB4 PLCB4 PLCB3 PLCB3 MRRF MRRF CYP2J2 CYP2J2 KCNJ6 KCNJ6 GNG2 GNG2 ADCY5 ADCY5 GNB5 GNB5 GNG4 GNG4 GNAO1 GNAO1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ALOX12Arachidonate 12-lipoxygenase, 12S type. (664 aa)
APPAmyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (935 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1984 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1871 aa)
SLC6A4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (630 aa)
TPH2Tryptophan hydroxylase 2. (491 aa)
GNAI2G protein subunit alpha i2. (436 aa)
GABRB1Gamma-aminobutyric acid type A receptor beta1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (476 aa)
CYP4X1Cytochrome P450 family 4 subfamily X member 1; Belongs to the cytochrome P450 family. (507 aa)
GNAI1G protein subunit alpha i1. (354 aa)
LOC101083342Phospholipase A2. (781 aa)
HTR1B5-hydroxytryptamine receptor 1B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopami [...] (389 aa)
LOC101089387Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (456 aa)
KCND2Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (630 aa)
GNG13G protein subunit gamma 13. (67 aa)
LOC101084129G_PROTEIN_RECEP_F1_2 domain-containing protein. (369 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
HTR1D5-hydroxytryptamine receptor 1D. (377 aa)
SLC18A1Solute carrier family 18 member A1. (519 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
GNB3G protein subunit beta 3. (339 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (804 aa)
SLC18A2Solute carrier family 18 member A2. (517 aa)
MAOBAmine oxidase. (520 aa)
ALOX5Arachidonate 5-lipoxygenase. (745 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
HTR1A5-hydroxytryptamine receptor 1A. (422 aa)
ALOX12BArachidonate 12-lipoxygenase, 12R type. (699 aa)
LOC102900772Uncharacterized protein. (247 aa)
KRASUncharacterized protein. (380 aa)
HTR2B5-hydroxytryptamine receptor 2B. (503 aa)
GNB1G protein subunit beta 1. (340 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (794 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
TPH1Tryptophan hydroxylase 1. (527 aa)
GNB2G protein subunit beta 2. (340 aa)
GNG14Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
KCNN2Potassium calcium-activated channel subfamily N member 2. (853 aa)
GNAQG protein subunit alpha q. (359 aa)
HTR1F5-hydroxytryptamine receptor 1F. (366 aa)
HTR65-hydroxytryptamine receptor 6; Belongs to the G-protein coupled receptor 1 family. (440 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
HTR2A5-hydroxytryptamine receptor 2A. (470 aa)
PLA2G4DPhospholipase A2. (814 aa)
GNB4G protein subunit beta 4. (340 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
PLA2G4APhospholipase A2. (749 aa)
GNAI3G protein subunit alpha i3. (354 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2187 aa)
LOC1010900405-hydroxytryptamine receptor 3C; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (447 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
HTR2C5-hydroxytryptamine receptor 2C. (458 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (392 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2498 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
HTR75-hydroxytryptamine receptor 7; Belongs to the G-protein coupled receptor 1 family. (442 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (659 aa)
HTR45-hydroxytryptamine receptor 4; Belongs to the G-protein coupled receptor 1 family. (469 aa)
MAOAAmine oxidase. (1178 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
DDCDopa decarboxylase. (480 aa)
HTR5A5-hydroxytryptamine receptor 5A. (527 aa)
GABRB3Gamma-aminobutyric acid type A receptor beta3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (495 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2216 aa)
ALOX15BArachidonate 15-lipoxygenase type B. (678 aa)
GNASGNAS complex locus. (968 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2202 aa)
PLA2G4EPhospholipase A2. (862 aa)
DUSP1Dual specificity phosphatase 1; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (434 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1209 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1245 aa)
MRRFProstaglandin-endoperoxide synthase 1. (633 aa)
CYP2J2Cytochrome P450 family 2 subfamily J member 2; Belongs to the cytochrome P450 family. (502 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (451 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (152 aa)
ADCY5Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1329 aa)
GNB5G protein subunit beta 5. (403 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (250 aa)
GNAO1G protein subunit alpha o1. (370 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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