STRINGSTRING
PRKCG PRKCG MAPK10 MAPK10 ITPR1 ITPR1 AKT3 AKT3 PPP2R1A PPP2R1A ITPR2 ITPR2 AKT1 AKT1 CALML6 CALML6 CALML4 CALML4 GNAI2 GNAI2 GNAI1 GNAI1 ATF4 ATF4 GNG13 GNG13 PRKCB PRKCB PPP1CC PPP1CC SLC18A1 SLC18A1 MAPK11 MAPK11 PRKCA PRKCA PPP2R5B PPP2R5B GNB3 GNB3 SLC18A2 SLC18A2 MAOB MAOB ITPR3 ITPR3 CREB3L3 CREB3L3 GRIN2A GRIN2A LOC102900772 LOC102900772 ATF6B ATF6B CREB3L1 CREB3L1 CALM2 CALM2 PPP2R3B PPP2R3B PPP1CA PPP1CA KIF5B KIF5B GNB1 GNB1 GNGT1 GNGT1 PRKACA PRKACA PPP2CB PPP2CB PPP2R2D PPP2R2D GNB2 GNB2 GNG14 GNG14 GSK3A GSK3A ATF2 ATF2 MAPK14 MAPK14 PPP2R3C PPP2R3C GNAQ GNAQ PPP3CB PPP3CB KCNJ3 KCNJ3 GNB4 GNB4 GNG11 GNG11 GNGT2 GNGT2 CALML3 CALML3 GNAI3 GNAI3 CACNA1C CACNA1C KIF5C KIF5C LOC101097703 LOC101097703 ARNTL ARNTL PPP2R2B PPP2R2B SCN1A SCN1A KCNJ5 KCNJ5 MAPK12 MAPK12 KCNJ9 KCNJ9 CREB5 CREB5 DRD5 DRD5 KIF5A KIF5A GNG3 GNG3 GRIA1 GRIA1 PPP2R5D PPP2R5D GRIA2 GRIA2 PLCB2 PLCB2 PPP3CA PPP3CA PPP1CB PPP1CB PPP2CA PPP2CA MAPK8 MAPK8 CLOCK CLOCK PPP2R3A PPP2R3A GNG5 GNG5 CALY CALY TH TH PRKACB PRKACB GNAL GNAL CACNA1A CACNA1A PPP3CC PPP3CC PLCB1 PLCB1 ENSFCAP00000043586 ENSFCAP00000043586 GSK3B GSK3B CAMK2B CAMK2B GRIN2B GRIN2B FOS FOS MAOA MAOA GNG12 GNG12 MAPK9 MAPK9 GNG8 GNG8 DDC DDC ARRB1 ARRB1 GRIA3 GRIA3 DRD1 DRD1 GNG10 GNG10 PPP2R2A PPP2R2A PPP2R5E PPP2R5E CACNA1D CACNA1D GNAS GNAS CACNA1B CACNA1B DRD4 DRD4 PLCB4 PLCB4 PLCB3 PLCB3 CREB3 CREB3 PPP2R1B PPP2R1B RPS14 RPS14 TOMT TOMT PPP1R1B PPP1R1B GRIA4 GRIA4 KCNJ6 KCNJ6 PPP2R5A PPP2R5A DRD3 DRD3 CREB3L2 CREB3L2 GNG2 GNG2 ADCY5 ADCY5 GNB5 GNB5 AKT2 AKT2 CAMK2D CAMK2D PPP2R2C PPP2R2C GNG4 GNG4 GNAO1 GNAO1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (606 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CALML6Calmodulin like 6. (180 aa)
CALML4Calmodulin like 4. (196 aa)
GNAI2G protein subunit alpha i2. (436 aa)
GNAI1G protein subunit alpha i1. (354 aa)
ATF4Activating transcription factor 4. (352 aa)
GNG13G protein subunit gamma 13. (67 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
SLC18A1Solute carrier family 18 member A1. (519 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (606 aa)
GNB3G protein subunit beta 3. (339 aa)
SLC18A2Solute carrier family 18 member A2. (517 aa)
MAOBAmine oxidase. (520 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (448 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
LOC102900772Uncharacterized protein. (247 aa)
ATF6BActivating transcription factor 6 beta. (628 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (149 aa)
PPP2R3BProtein phosphatase 2 regulatory subunit B''beta. (579 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (963 aa)
GNB1G protein subunit beta 1. (340 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (488 aa)
GNB2G protein subunit beta 2. (340 aa)
GNG14Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GSK3AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (453 aa)
GNAQG protein subunit alpha q. (359 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
GNB4G protein subunit beta 4. (340 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
GNAI3G protein subunit alpha i3. (354 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2187 aa)
KIF5CKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (957 aa)
LOC101097703EF-hand domain-containing protein; Belongs to the calmodulin family. (86 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (626 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (583 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2008 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (392 aa)
CREB5cAMP responsive element binding protein 5. (523 aa)
DRD5Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. (474 aa)
KIF5AKinesin family member 5A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1039 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (906 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (678 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (333 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CLOCKClock circadian regulator. (899 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1150 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CALYCalcyon neuron specific vesicular protein. (223 aa)
THInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (557 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
GNALG protein subunit alpha L. (455 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2498 aa)
PPP3CCSerine/threonine-protein phosphatase. (523 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
ENSFCAP00000043586Uncharacterized protein. (261 aa)
GSK3BProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (433 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (748 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1486 aa)
FOSProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa)
MAOAAmine oxidase. (1178 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
DDCDopa decarboxylase. (480 aa)
ARRB1Arrestin beta 1. (421 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (463 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2216 aa)
GNASGNAS complex locus. (968 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2202 aa)
DRD4G_PROTEIN_RECEP_F1_2 domain-containing protein. (595 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1209 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1245 aa)
CREB3cAMP responsive element binding protein 3. (399 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (772 aa)
RPS14Calcium/calmodulin dependent protein kinase II alpha. (566 aa)
TOMTUncharacterized protein. (318 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (209 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (901 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (451 aa)
PPP2R5AProtein phosphatase 2 regulatory subunit B'alpha. (642 aa)
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (447 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (536 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (152 aa)
ADCY5Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1329 aa)
GNB5G protein subunit beta 5. (403 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (544 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (488 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (250 aa)
GNAO1G protein subunit alpha o1. (370 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
Server load: low (26%) [HD]