STRINGSTRING
MTOR MTOR PCK1 PCK1 IRS4 IRS4 PRKAB1 PRKAB1 PDPK1 PDPK1 SREBF1 SREBF1 FBP2 FBP2 G6PC3 G6PC3 MAPK10 MAPK10 RPS6 RPS6 PHKG1 PHKG1 HRAS HRAS SLC2A4 SLC2A4 EIF4E1B EIF4E1B HK3 HK3 AKT3 AKT3 PTPN1 PTPN1 SHC3 SHC3 HKDC1 HKDC1 HK1 HK1 AKT1 AKT1 TRIP10 TRIP10 INPPL1 INPPL1 HK2 HK2 CRKL CRKL G6PC2 G6PC2 CALML6 CALML6 CALML4 CALML4 PHKA1 PHKA1 FLOT1 FLOT1 ACACB ACACB PYGB PYGB PHKB PHKB FBP1 FBP1 PPP1R3C PPP1R3C PHKG2 PHKG2 EIF4EBP1 EIF4EBP1 PIK3R1 PIK3R1 PPP1CC PPP1CC FASN FASN MKNK2 MKNK2 PYGM PYGM GYS2 GYS2 BRAF BRAF RHEB RHEB MAP2K2 MAP2K2 GCK GCK SHC2 SHC2 KRAS KRAS CALM2 CALM2 PPP1R3A PPP1R3A PPP1CA PPP1CA CBL CBL LIPE LIPE IRS1 IRS1 PRKACA PRKACA PDE3B PDE3B SOCS3 SOCS3 PPP1R3D PPP1R3D LOC101100432 LOC101100432 RPS6KB1 RPS6KB1 MAP2K1 MAP2K1 SOS1 SOS1 PRKAR1B PRKAR1B PIK3CD PIK3CD GRB2 GRB2 PRKAA1 PRKAA1 SOS2 SOS2 PRKCI PRKCI SH2B2 SH2B2 MAPK1 MAPK1 G6PC G6PC CBLB CBLB PIK3CB PIK3CB CALML3 CALML3 PRKAG3 PRKAG3 LOC101097703 LOC101097703 SHC4 SHC4 SOCS4 SOCS4 INSR INSR PYGL PYGL RAF1 RAF1 PRKAG1 PRKAG1 PRKAR2B PRKAR2B TSC2 TSC2 NRAS NRAS PRKAA2 PRKAA2 MAPK3 MAPK3 PHKA2 PHKA2 ACACA ACACA FLOT2 FLOT2 RHOQ RHOQ PRKAB2 PRKAB2 PIK3CA PIK3CA RAPGEF1 RAPGEF1 PPP1CB PPP1CB MAPK8 MAPK8 CRADD CRADD FOXO1 FOXO1 EXOC7 EXOC7 PRKACB PRKACB PPP1R3E PPP1R3E RPTOR RPTOR ARAF ARAF EIF4E EIF4E TSC1 TSC1 PPP1R3F PPP1R3F PIK3R2 PIK3R2 ENSFCAP00000043586 ENSFCAP00000043586 GSK3B GSK3B IKBKB IKBKB PKLR PKLR PPP1R3B PPP1R3B PRKAR2A PRKAR2A CRK CRK GYS1 GYS1 PIK3R3 PIK3R3 IRS2 IRS2 PCK2 PCK2 BAD BAD MAPK9 MAPK9 SOCS1 SOCS1 PRKAR1A PRKAR1A EIF4E2 EIF4E2 MKNK1 MKNK1 INPP5A INPP5A PPARGC1A PPARGC1A RPS6KB2 RPS6KB2 PRKCZ PRKCZ ELK1 ELK1 AKT2 AKT2 PTPRF PTPRF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
IRS4Insulin receptor substrate 4. (1251 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1147 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (339 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
RPS6Ribosomal protein S6. (315 aa)
PHKG1Phosphorylase kinase catalytic subunit gamma 1; Belongs to the protein kinase superfamily. (387 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (585 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (213 aa)
HK3Hexokinase 3. (924 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (427 aa)
SHC3SHC adaptor protein 3. (587 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
HK1Hexokinase 1. (1056 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
TRIP10Thyroid hormone receptor interactor 10. (603 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1264 aa)
HK2Hexokinase 2. (917 aa)
CRKLCRK like proto-oncogene, adaptor protein. (342 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
CALML6Calmodulin like 6. (180 aa)
CALML4Calmodulin like 4. (196 aa)
PHKA1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1238 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
ACACBAcetyl-CoA carboxylase beta. (2447 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1093 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
PHKG2Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (406 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
FASNFatty acid synthase. (2655 aa)
MKNK2MAPK interacting serine/threonine kinase 2. (610 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (702 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (804 aa)
RHEBRas homolog, mTORC1 binding. (187 aa)
MAP2K2Protein kinase domain-containing protein. (549 aa)
GCKPhosphotransferase. (466 aa)
SHC2SHC adaptor protein 2. (583 aa)
KRASUncharacterized protein. (380 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (149 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1122 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
CBLCbl proto-oncogene. (902 aa)
LIPELipase E, hormone sensitive type. (772 aa)
IRS1Insulin receptor substrate 1. (1234 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
PDE3BPhosphodiesterase. (1122 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit. (297 aa)
LOC101100432Uncharacterized protein. (514 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (378 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PRKAA1Non-specific serine/threonine protein kinase. (573 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
SH2B2SH2B adaptor protein 2. (679 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
G6PCGlucose-6-phosphatase; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity). Belongs to the glucose-6-phosphatase family. (357 aa)
CBLBCbl proto-oncogene B. (1182 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (607 aa)
LOC101097703EF-hand domain-containing protein; Belongs to the calmodulin family. (86 aa)
SHC4SHC adaptor protein 4. (630 aa)
SOCS4Suppressor of cytokine signaling 4. (441 aa)
INSRTyrosine-protein kinase receptor. (1381 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (865 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (330 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (618 aa)
TSC2TSC complex subunit 2. (1806 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1290 aa)
ACACAAcetyl-CoA carboxylase alpha. (2385 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (553 aa)
RHOQRas homolog family member Q. (214 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1270 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (333 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CRADDUncharacterized protein. (398 aa)
FOXO1Forkhead box O1. (662 aa)
EXOC7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (737 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (279 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (659 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (237 aa)
TSC1TSC complex subunit 1. (1110 aa)
PPP1R3FProtein phosphatase 1 regulatory subunit 3F. (812 aa)
PIK3R2Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
ENSFCAP00000043586Uncharacterized protein. (261 aa)
GSK3BProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (433 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (760 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (634 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (304 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (401 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (737 aa)
PIK3R3Uncharacterized protein. (461 aa)
IRS2Insulin receptor substrate 2. (1335 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (620 aa)
BADBCL2 associated agonist of cell death. (273 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
SOCS1Suppressor of cytokine signaling 1. (203 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (569 aa)
EIF4E2Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (358 aa)
MKNK1MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (419 aa)
INPP5AInositol polyphosphate-5-phosphatase A. (475 aa)
PPARGC1APPARG coactivator 1 alpha. (803 aa)
RPS6KB2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (497 aa)
PRKCZProtein kinase C zeta. (649 aa)
ELK1ETS transcription factor ELK1. (487 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
PTPRFProtein tyrosine phosphatase receptor type F. (2147 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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