STRINGSTRING
ADCY6 ADCY6 KRT18 KRT18 HBEGF HBEGF KRT19 KRT19 KRT24 KRT24 KRT25 KRT25 KRT10 KRT10 KRT12 KRT12 KRT39 KRT39 ITPR1 ITPR1 HRAS HRAS ADCY3 ADCY3 POMC POMC AKT3 AKT3 PRKCD PRKCD SHC3 SHC3 ITPR2 ITPR2 HSPA1L HSPA1L AKT1 AKT1 ADCY4 ADCY4 CALML6 CALML6 ADCY8 ADCY8 CALML4 CALML4 GNAI2 GNAI2 GNAI1 GNAI1 HSPA2 HSPA2 CTSD CTSD GABBR2 GABBR2 ATF4 ATF4 SLC29A1 SLC29A1 GRM1 GRM1 PIK3R1 PIK3R1 KRT9 KRT9 TFF1 TFF1 NOS3 NOS3 ITPR3 ITPR3 MMP9 MMP9 MAP2K2 MAP2K2 CREB3L3 CREB3L3 NCOA3 NCOA3 SHC2 SHC2 LOC102900772 LOC102900772 ATF6B ATF6B CREB3L1 CREB3L1 KRAS KRAS LOC101087114 LOC101087114 SP1 SP1 CALM2 CALM2 ADCY9 ADCY9 PRKACA PRKACA NCOA2 NCOA2 FKBP5 FKBP5 ESR1 ESR1 JUN JUN MAP2K1 MAP2K1 SOS1 SOS1 KRT26 KRT26 ATF2 ATF2 PIK3CD PIK3CD GRB2 GRB2 SOS2 SOS2 GNAQ GNAQ KCNJ3 KCNJ3 MAPK1 MAPK1 KRT36 KRT36 PIK3CB PIK3CB CALML3 CALML3 KRT20 KRT20 GNAI3 GNAI3 ADCY7 ADCY7 OPRM1 OPRM1 LOC101097703 LOC101097703 SHC4 SHC4 FKBP4 FKBP4 KCNJ5 KCNJ5 KCNJ9 KCNJ9 RAF1 RAF1 CREB5 CREB5 NRAS NRAS MAPK3 MAPK3 KRT32 KRT32 RARA RARA PLCB2 PLCB2 PIK3CA PIK3CA HSPA8 HSPA8 MMP2 MMP2 PRKACB PRKACB TGFA TGFA SRC SRC EGFR EGFR HSP90AA1 HSP90AA1 PLCB1 PLCB1 NCOA1 NCOA1 ESR2 ESR2 PIK3R2 PIK3R2 ENSFCAP00000043586 ENSFCAP00000043586 GPER1 GPER1 FOS FOS KRT40 KRT40 PIK3R3 PIK3R3 LOC101087886 LOC101087886 PGR PGR LOC111559129 LOC111559129 GNAS GNAS EBAG9 EBAG9 PLCB4 PLCB4 ADCY2 ADCY2 PLCB3 PLCB3 CREB3 CREB3 ADCY1 ADCY1 HSP90B1 HSP90B1 KCNJ6 KCNJ6 CREB3L2 CREB3L2 ADCY5 ADCY5 AKT2 AKT2 GNAO1 GNAO1 BCL2 BCL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1208 aa)
KRT18Keratin 18; Belongs to the intermediate filament family. (430 aa)
HBEGFHeparin binding EGF like growth factor. (305 aa)
KRT19IF rod domain-containing protein; Belongs to the intermediate filament family. (399 aa)
KRT24Keratin 24; Belongs to the intermediate filament family. (530 aa)
KRT25Keratin 25; Belongs to the intermediate filament family. (450 aa)
KRT10Keratin 10; Belongs to the intermediate filament family. (546 aa)
KRT12Keratin 12; Belongs to the intermediate filament family. (492 aa)
KRT39IF rod domain-containing protein; Belongs to the intermediate filament family. (474 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
POMCProopiomelanocortin. (258 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
SHC3SHC adaptor protein 3. (587 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1010 aa)
CALML6Calmodulin like 6. (180 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
CALML4Calmodulin like 4. (196 aa)
GNAI2G protein subunit alpha i2. (436 aa)
GNAI1G protein subunit alpha i1. (354 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (639 aa)
CTSDPeptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (408 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (941 aa)
ATF4Activating transcription factor 4. (352 aa)
SLC29A1Heat shock protein 90 alpha family class B member 1. (740 aa)
GRM1Glutamate metabotropic receptor 1. (1190 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
KRT9Keratin 9; Belongs to the intermediate filament family. (643 aa)
TFF1Trefoil factor family peptide 1. (81 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
MMP9Matrix metallopeptidase 9. (705 aa)
MAP2K2Protein kinase domain-containing protein. (549 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (448 aa)
NCOA3Nuclear receptor coactivator. (1412 aa)
SHC2SHC adaptor protein 2. (583 aa)
LOC102900772Uncharacterized protein. (247 aa)
ATF6BActivating transcription factor 6 beta. (628 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
KRASUncharacterized protein. (380 aa)
LOC101087114IF rod domain-containing protein; Belongs to the intermediate filament family. (457 aa)
SP1Sp1 transcription factor. (786 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (149 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
NCOA2Nuclear receptor coactivator. (1470 aa)
FKBP5Peptidylprolyl isomerase. (457 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
KRT26Keratin 26; Belongs to the intermediate filament family. (465 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
GNAQG protein subunit alpha q. (359 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
KRT36IF rod domain-containing protein; Belongs to the intermediate filament family. (467 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
KRT20Keratin 20; Belongs to the intermediate filament family. (421 aa)
GNAI3G protein subunit alpha i3. (354 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
OPRM1Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (419 aa)
LOC101097703EF-hand domain-containing protein; Belongs to the calmodulin family. (86 aa)
SHC4SHC adaptor protein 4. (630 aa)
FKBP4Peptidylprolyl isomerase. (464 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (392 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
CREB5cAMP responsive element binding protein 5. (523 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
KRT32Keratin 32; Belongs to the intermediate filament family. (449 aa)
RARARetinoic acid receptor alpha. (462 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (667 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
TGFATransforming growth factor alpha. (192 aa)
SRCTyrosine-protein kinase. (678 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (753 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
NCOA1Nuclear receptor coactivator. (1492 aa)
ESR2Estrogen receptor 2. (574 aa)
PIK3R2Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
ENSFCAP00000043586Uncharacterized protein. (261 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
FOSProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa)
KRT40IF rod domain-containing protein; Belongs to the intermediate filament family. (432 aa)
PIK3R3Uncharacterized protein. (461 aa)
LOC101087886IF rod domain-containing protein; Belongs to the intermediate filament family. (442 aa)
PGRProgesterone receptor. (932 aa)
LOC111559129IF rod domain-containing protein; Belongs to the intermediate filament family. (431 aa)
GNASGNAS complex locus. (968 aa)
EBAG9Estrogen receptor binding site associated antigen 9. (321 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1209 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1135 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1245 aa)
CREB3cAMP responsive element binding protein 3. (399 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1148 aa)
HSP90B1Heat shock protein 90 beta family member 1. (809 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (451 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (536 aa)
ADCY5Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1329 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
GNAO1G protein subunit alpha o1. (370 aa)
BCL2BCL2 apoptosis regulator. (237 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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